Pathology

Hasem Habelhah, PhD

Portrait

Associate Professor of Pathology

Contact Information

Primary Office: 1173 Medical Laboratories
Iowa City, IA 52242
Primary Office Phone: 319-335-6517

Email: hasem-habelhah@uiowa.edu
Web: Dr. Habelhah's Research Laboratory

Education

BS, Biology, Beijing Normal University, Beijing, China
MS, Department of Biology, Beijing Normal University, China
PhD, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan

Post Doctoral, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
Post Doctoral, D.H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Medical Scientist Training Program

Research Summary

Interests: Role of TRAF2 in oncogene- and stress-induced NF-kB activation and resistance to apoptosis in cancer cells.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

All Publications

Workman L, Habelhah H.  TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.  Cellular signalling.  2013. 25(8):1654-64.
[PubMed]

Blackwell K, Zhang L, Workman L, Ting A, Iwai K, Habelhah H.  Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation.  Molecular and cellular biology.  2013. 33(10):1901-15.
[PubMed]

Shen R, Zhou A, Kim E, Lim E, Habelhah H, Hahn W.  IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation.  Molecular and cellular biology.  2012. 
[PubMed]

Zhang L, Blackwell K, Altaeva A, Shi Z, Habelhah H.  TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death.  Molecular biology of the cell.  2011. 22(1):128-40.
[PubMed]

Habelhah H.  Emerging complexity of protein ubiquitination in the NF-κB pathway.  Genes & cancer.  2010. 1(7):735-747.
[PubMed]

Zhang L, Blackwell K, Shi Z, Habelhah H.  The RING domain of TRAF2 plays an essential role in the inhibition of TNFα-induced cell death but not in the activation of NF-κB.  Journal of molecular biology.  2010. 396(3):528-39.
[PubMed]

Thomas G, Zhang L, Blackwell K, Habelhah H.  Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation.  Cancer research.  2009. 69(8):3665-72.
[PubMed]

Blackwell K, Zhang L, Thomas G, Sun S, Nakano H, Habelhah H.  TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.  Molecular and cellular biology.  2009. 29(2):303-14.
[PubMed]

Zhang L, Blackwell K, Thomas G, Sun S, Yeh W, Habelhah H.  TRAF2 suppresses basal IKK activity in resting cells and TNFα can activate IKK in TRAF2 and TRAF5 double knockout cells.  Journal of molecular biology.  2009. 389(3):495-510.
[PubMed]

López-Bergami P, Habelhah H, Bhoumik A, Zhang W, Wang L, Ronai Z.  RACK1 mediates activation of JNK by protein kinase C [corrected].  Molecular cell.  2005. 19(3):309-20.
[PubMed]

Habelhah H, Laine A, Erdjument-Bromage H, Tempst P, Gershwin M, Bowtell D, Ronai Z.  Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.  The Journal of biological chemistry.  2004. 279(51):53782-8.
[PubMed]

Habelhah H, Nakayama K, Frew I, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell P, Bowtell D, Ronai Z.  Siah2 regulates stability of prolyl-hydroxylases, controls HIF1α abundance, and modulates physiological responses to hypoxia.  Cell.  2004. 117(7):941-52.
[PubMed]

Habelhah H, Takahashi S, Cho S, Kadoya T, Watanabe T, Ronai Z.  Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB.  The EMBO journal.  2004. 23(2):322-32.
[PubMed]

Habelhah H, Frew I, Laine A, Janes P, Relaix F, Sassoon D, Bowtell D, Ronai Z.  Stress-induced decrease in TRAF2 stability is mediated by Siah2.  The EMBO journal.  2002. 21(21):5756-65.
[PubMed]

Minamoto T, Buschmann T, Habelhah H, Matusevich E, Tahara H, Boerresen-Dale A, Harris C, Sidransky D, Ronai Z.  Distinct pattern of p53 phosphorylation in human tumors.  Oncogene.  2001. 20(26):3341-7.
[PubMed]

Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame A, Shokat K, Hentze M, Ronai Z.  ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.  Nature cell biology.  2001. 3(3):325-30.
[PubMed]

Habelhah H, Shah K, Huang L, Burlingame A, Shokat K, Ronai Z.  Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.  The Journal of biological chemistry.  2001. 276(21):18090-5.
[PubMed]

Choi S, Kobayashi M, Wang J, Habelhah H, Okada F, Hamada J, Moriuchi T, Totsuka Y, Hosokawa M.  Activated leukocyte cell adhesion molecule (ALCAM) and annexin II are involved in the metastatic progression of tumor cells after chemotherapy with Adriamycin.  Clinical & experimental metastasis.  2000. 18(1):45-50.
[PubMed]

Okada F, Kawaguchi T, Habelhah H, Kobayashi T, Tazawa H, Takeichi N, Kitagawa T, Hosokawa M.  Conversion of human colonic adenoma cells to adenocarcinoma cells through inflammation in nude mice.  Laboratory investigation; a journal of technical methods and pathology.  2000. 80(11):1617-28.
[PubMed]

Yin Z, Ivanov V, Habelhah H, Tew K, Ronai Z.  Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.  Cancer research.  2000. 60(15):4053-7.
[PubMed]

Habelhah H, Habelhah H, Okada F, Kobayashi M, Nakai K, Choi S, Hamada J, Moriuchi T, Kaya M, Yoshida K, Fujinaga K, Hosokawa M.  Increased E1AF expression in mouse fibrosarcoma promotes metastasis through induction of MT1-MMP expression.  Oncogene.  1999. 18(9):1771-6.
[PubMed]

Choi S, Okada F, Kobayashi M, Habelhah H, Nakae D, Konishi Y, Totsuka Y, Hosokawa M.  Single treatment with cisplatin or UFT, but not their combination treatment enhances the metastatic capacity of mouse fibrosarcoma cells.  Anti-cancer drugs.  1999. 10(2):235-43.
[PubMed]

Habelhah H.  [Induction of manganese superoxide dismutase by an immunopotentiator as a mechanism of inhibiting of malignant progression of murine tumor cells].  [Hokkaido igaku zasshi] The Hokkaido journal of medical science.  1998. 73(5):519-29.
[PubMed]

Habelhah H, Okada F, Nakai K, Choi S, Hamada J, Kobayashi M, Hosokawa M.  Polysaccharide K induces Mn superoxide dismutase (Mn-SOD) in tumor tissues and inhibits malignant progression of QR-32 tumor cells: possible roles of interferon alpha, tumor necrosis factor-α and transforming growth factor-β in Mn-SOD induction by polysaccharide K.  Cancer immunology, immunotherapy.  1998. 46(6):338-44.
[PubMed]

Date Last Modified: 06/07/2014 - 21:56:23