David Meyerholz, DVM, PhD


Director, Division of Comparative Pathology
Associate Professor of Pathology

Contact Information

Primary Office: 1165 Medical Laboratories
Iowa City, IA 52242
Phone: 319-353-4589

Web: Division of Comparative Pathology


DVM, Iowa State University
MS, Iowa State University
PhD, Iowa State University

Residency, Veterinary Pathology, Iowa State University

Licensure and Certifications

Diplomate, American College of Veterinary Microbiologists (Virology)
Diplomate, American College of Veterinary Pathologists

Research Summary

David Meyerholz DVM, PhD is a research pathologist who studies cardiovascular disease mechanisms in animal models for translational applications. He is an Associate Professor of Pathology and serves as Director of the Division of Comparative Pathology.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Center for Immunology and Immune-based Diseases
Cystic Fibrosis Research Center
Institute for Clinical and Translational Science

Selected Publications

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Stoltz D, Meyerholz D, Welsh M.  Origins of Cystic Fibrosis Lung Disease.  The New England Journal of Medicine.  2015. 372(4):351-362.

Hernandez F, Huang L, Olson M, Powers K, Hernandez L, Meyerholz D, Thedens D, Behlke M, Horswill A, McNamara J.  Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.  Nature medicine.  2014. 20(3):301-306.

Adam R, Michalski  A, Bauer C, Abou Alaiwa  M, Gross T, Awadalla  M, Bouzek  D, Gansemer  N, Taft P, Hoegger  M, Diwakar  A, Ochs M, Reinhardt  J, Hoffman E, Beichel  R, Meyerholz D, Stoltz D.  Air trapping and airflow obstruction in newborn cystic fibrosis piglets.  American journal of respiratory and critical care medicine.  2013. 188(12):1434-41.

Sanders P, Koval O, Jaffer O, Prasad A, Businga T, Scott J, Hayden P, Luczak E, Dickey D, Allamargot C, Olivier A, Meyerholz D, Robison A, Winder D, Blackwell T, Dworski R, Sammut D, Wagner B, Buettner G, Pope R, Miller F, Dibbern M, Haitchi H, Mohler P, Howarth P, Zabner J, Kline J, Grumbach I, Anderson M.  CaMKII Is Essential for the Proasthmatic Effects of Oxidation.  Science translational medicine.  2013. 5(195):195-97.

Stoltz D, Rokhlina T, Ernst S, Pezzulo A, Ostedgaard L, Karp P, Samuel M, Reznikov L, Rector M, Gansemer N, Bouzek D, Alaiwa M, Hoegger M, Ludwig P, Taft P, Wallen T, Wohlford-Lenane C, McMenimen J, Chen J, Bogen K, Adam R, Hornick E, Nelson G, Hoffman E, Chang E, Zabner J, McCray P, Prather R, Meyerholz D, Welsh M.  Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.  Journal of Clinical Investigation.  2013. 123(6):2685-93.

Klesney-Tait  J, Keck K, Li X, Gilfillan  S, Otero  K, Baruah  S, Meyerholz D, Varga S, Knudson C, Moninger  T, Moreland  J, Zabner J, Colonna M.  Transepithelial migration of neutrophils into the lung requires TREM-1.  Journal of Clinical Investigation.  2012. 123:138-149.

Ostedgaard L, Meyerholz D, Chen J, Pezzulo A, Karp P, Rokhlina T, Ernst S, Hanfland R, Reznikov L, Ludwig P, Rogan M, Davis G, Dohrn C, Wohlford-Lenane C, Taft P, Rector M, Hornick E, Nassar B, Samuel M, Zhang Y, Richter S, Uc A, Shilyansky J, Prather R, McCray P, Zabner J, Welsh M, Stoltz D.  The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.  Science translational medicine.  2011. 3(74):74ra24.

Stoltz D, Meyerholz D, Pezzulo A, Ramachandran S, Rogan M, Davis G, Hanfland R, Wohlford-Lenane C, Dohrn C, Bartlett J, Nelson G, Chang E, Taft P, Ludwig P, Estin M, Hornick E, Launspach J, Samuel M, Rokhlina T, Karp P, Ostedgaard L, Uc A, Starner T, Horswill A, Brogden K, Prather R, Richter S, Shilyansky J, McCray P, Zabner J, Welsh M.  Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.  Science translational medicine.  2010. 2(29):29ra31.

Meyerholz D, Stoltz D, Namati E, Ramachandran  S, Pezzulo  A, Smith  A, Rector M, Suter  M, Kao S, McLennan  G, Tearney  G, Zabner J, McCray, Jr. P, Welsh M.  Loss of CFTR function produces abnormalities in tracheal development in neonatal pigs and young children.  American Journal of Respiratory and Critical Care Medicine.  2010. 182(10):1251-61.

Meyerholz D, Stoltz D, Pezzulo A, Welsh M.  Pathology of gastrointestinal organs in a porcine model of cystic fibrosis.  The American journal of pathology.  2010. 176(3):1377-89.

Date Last Modified: 08/31/2015 - 16:17:12