David Meyerholz, DVM, PhD


Director, Division of Comparative Pathology
Associate Professor of Pathology

Contact Information

Primary Office: 1165 Medical Laboratories
Iowa City, IA 52242
Phone: 319-353-4589

Web: Division of Comparative Pathology


DVM, Iowa State University
MS, Iowa State University
PhD, Iowa State University

Residency, Veterinary Pathology, Iowa State University

Licensure and Certifications

Diplomate, American College of Veterinary Microbiologists (Virology)
Diplomate, American College of Veterinary Pathologists

Research Summary

Dr. Meyerholz studies cystic fibrosis (CF), a genetic condition cause by mutations in CFTR gene. Goals of his research are to better understand the molecular origins of CF disease, identify new biomarkers and evaluate novel treatments. He also has research interests in diseases of the lung (e.g. influenza, MERS-CoV, RSV, SARS-COV) as well as comparative pathology of cardiovascular disease, cancer and neurofibromatosis-1. Dr. Meyerholz has published >130 peer-reviewed papers in scientific journals.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Center for Immunology and Immune-based Diseases
Cystic Fibrosis Research Center
Institute for Clinical and Translational Science

Selected Publications

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Cook D, Rector M, Bouzek D, Michalski A, Gansemer N, Reznikov L, Li  X, Stroik M, Ostedgaard L, Abou Alaiwa M, Thompson M, Prakash Y, Krishnan R, Meyerholz D, Seow C, Stoltz D.  CFTR in Sarcoplasmic Reticulum of Airway Smooth Muscle: Implications for Airway Contractility..  American journal of respiratory and critical care medicine.  2015 October 21. 

Stoltz D, Meyerholz D, Welsh M.  Origins of Cystic Fibrosis Lung Disease.  The New England Journal of Medicine.  2015. 372(4):351-362.

Zhao J, Perera R, Kayali G, Meyerholz D, Perlman S, Peiris M.  Passive Immunotherapy With Dromedary Immune Serum In An Experimental Animal Model For MERS Coronavirus Infection.  Journal of virology.  2015. 

Knudson C, Hartwig S, Meyerholz D, Varga S.  RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets.  PLoS pathogens.  2015. 11(3):e1004757.

Hernandez F, Huang L, Olson M, Powers K, Hernandez L, Meyerholz D, Thedens D, Behlke M, Horswill A, McNamara J.  Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe.  Nature medicine.  2014. 20(3):301-306.

Adam R, Michalski  A, Bauer C, Abou Alaiwa  M, Gross T, Awadalla  M, Bouzek  D, Gansemer  N, Taft P, Hoegger  M, Diwakar  A, Ochs M, Reinhardt  J, Hoffman E, Beichel  R, Meyerholz D, Stoltz D.  Air trapping and airflow obstruction in newborn cystic fibrosis piglets.  American journal of respiratory and critical care medicine.  2013. 188(12):1434-41.

Klesney-Tait  J, Keck K, Li X, Gilfillan  S, Otero  K, Baruah  S, Meyerholz D, Varga S, Knudson C, Moninger  T, Moreland  J, Zabner J, Colonna M.  Transepithelial migration of neutrophils into the lung requires TREM-1.  Journal of Clinical Investigation.  2012. 123:138-149.

Ostedgaard L, Meyerholz D, Chen J, Pezzulo A, Karp P, Rokhlina T, Ernst S, Hanfland R, Reznikov L, Ludwig P, Rogan M, Davis G, Dohrn C, Wohlford-Lenane C, Taft P, Rector M, Hornick E, Nassar B, Samuel M, Zhang Y, Richter S, Uc A, Shilyansky J, Prather R, McCray P, Zabner J, Welsh M, Stoltz D.  The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.  Science translational medicine.  2011. 3(74):74ra24.

Stoltz D, Meyerholz D, Pezzulo A, Ramachandran S, Rogan M, Davis G, Hanfland R, Wohlford-Lenane C, Dohrn C, Bartlett J, Nelson G, Chang E, Taft P, Ludwig P, Estin M, Hornick E, Launspach J, Samuel M, Rokhlina T, Karp P, Ostedgaard L, Uc A, Starner T, Horswill A, Brogden K, Prather R, Richter S, Shilyansky J, McCray P, Zabner J, Welsh M.  Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.  Science translational medicine.  2010. 2(29):29ra31.

Meyerholz D, Stoltz D, Namati E, Ramachandran  S, Pezzulo  A, Smith  A, Rector M, Suter  M, Kao S, McLennan  G, Tearney  G, Zabner J, McCray, Jr. P, Welsh M.  Loss of CFTR function produces abnormalities in tracheal development in neonatal pigs and young children.  American Journal of Respiratory and Critical Care Medicine.  2010. 182(10):1251-61.

Date Last Modified: 11/18/2015 - 09:15:07