Pathology

Deqin Ma, MD, PhD

Portrait

Clinical Assistant Professor of Pathology  - Anatomic and Clinical Pathology

Contact Information

Primary Office: BT6008 General Hospital
Iowa City, IA 52242
Primary Office Phone: 319-384-5700

Email: deqin-ma@uiowa.edu

Education

MD, Shandong Medical University, Jinan, P.R. China
MS, Biochemistry, Shandong Medical University, Jinan, P.R. China
PhD, Biochemistry, University of Kentucky Medical Center, Lexington, KY

Postdoctoral Scholar, Hematology/Oncology, University of Kentucky Medical Center, Department of Pediatrics, Lexington, KY
Residency, Anatomic Pathology, National Cancer Institute/National Institutes of Health, Bethesda, MD
Fellowship, Molecular Genetic Pathology, M.D. Anderson Cancer Center, University of Texas, Houston, TX
Fellowship, Surgical Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA

Licensure and Certifications

Diplomat, Molecular Genetic Pathology, American Board of Pathology
Diplomat, Anatomic Pathology, American Board of Pathology

Research Summary

My research interest is primarily focused on developing molecular oncology tests and their application in the study of tumor/metastatic suppressors.

All Publications

Thomas A, Askeland R, Guseva N, Sompallae S, Ma D.  Molecular and immunohistochemical profiling of invasive micropapillary carcinoma of the breast.  Pathology and Laboratory Medicine International.  2014 October 3. 6(2014:6):33-40.

Gailey M, Stence A, Jensen C, Ma D.  Multi-platform comparison of molecular oncology tests performed on cytology specimens and formalin-fixed, paraffin-embedded tissue.  Cancer Cytopathology.  2014 September 3. 
[PubMed]

McCorkle J, Leonard M, Kraner S, Ma D, Zimmer S, Kaetzel D,  .  The metastasis suppressor NME1 regulates expression of genes linked to metastasis and patient outcome in melanoma and breast carcinoma.  Cancer Genomics & Proteomics.  2014 July 08. 11(4):175-194.
[PubMed]

Snow A, Stence A, Pruessner J, Bossler A, Ma D.  A simple and cost-effective method of DNA extraction from small formalin-fixed paraffin-embedded tissue for molecular oncology testing.  BMC Clinical Pathology;  2014. 

Mathur G, Ma D.  Coexistence of tyrosine kinase inhibitor-sensitizing and resistant EGFR mutations in an untreated lung adenocarcinoma patient and response to erlotinib.  J Thorac Oncol;  2014. 

Snow A, Stence A, Pruessner J, Bossler A, Ma D.  A simple and cost-effective method of DNA extraction from small formalin-fixed paraffin-embedded tissue for molecular oncology testing.  BMC Clinical Pathology;  2014. 

Ma D, Stence A, Bossler A, Bellizzi A.  Identification of c-KIT activating mutation in pediatric solitary mastocytoma.  Histopathology.  2014 January. 64(2):218-25.
[PubMed]

Snow A, Milhem M, Bossler A, Ma D.  A simple and cost-effective method of DNA extraction from small formalin-fixed paraffin-embedded tissue for molecular oncology testing: a practical approach.  102nd United States and Canadian Academy of Pathology Annual Meeting, Baltimore, MD.  2013. 

Snow A, Stence A, Pruessner J, Forde S, Elder S, Bossler A, Ma D.  Frequent loss of PTEN and NM23H1 in melanomas harboring a BRAF V600E mutation-implications for targeted therapy.  102nd United States and Canadian Academy of Pathology Annual Meeting, Baltimore, MD.  2013. 

Ma D, Dahmoush L, Guseva N, Sompallae T, Robinson R.  Identification of novel KIT mutation in synchronous papillary thyroid carcinoma from malignant struma ovariii and thyroid by next generation sequencing.  American Association for Molecular Pathology Annual Meeting, Phoenix, AZ.  2013. 

Takeshi U, Ma D, Sepulveda A.  Molecular Pathology of Inflammatory Bowel Diseases Associated Neoplasia.  Springer, LLC, New York.  2013. 

Uehara T, Ma D, Yao Y, Lynch J, Morales K, Ziober A, Feldman M, Ota H, Sepulveda A.  H. pylori Infection Is Associated with DNA Damage of Lgr5-Positive Epithelial Stem Cells in the Stomach of Patients with Gastric Cancer.  Digestive diseases and sciences.  2012 September. 
[PubMed]

Ma D, Chen Z, Nero C, Patel K, Daoud E, Cheng H, Djordjevic B, Broaddus R, Medeiros L, Rashid A, Luthra R.  Somatic deletions of the polyA tract in the 3' untranslated region of epidermal growth factor receptor are common in microsatellite instability-high endometrial and colorectal carcinomas.  Archives of pathology & laboratory medicine.  2012 May. 136(5):510-6.
[PubMed]

Ma D, Caponetti G, Hackman J, Heusel H, Bossler A.  Evaluation of multiplex quantitative measurement of BCR–ABL1 using International reporting scale.  American Association for Molecular Pathology Annual Meeting, Long Beach, CA.  2012. 

Ma D, Stence A, Hackman J, Pruessner J, Buhay J, Forde S, Zubcic M, Bellizzi A, Heusel J, Bossler A.  Identification of c-KIT activating mutation in pediatric solitary mastocytoma.  Association for Molecular Pathology Annual Meeting, Long Beach, CA.  2012. 

Caponetti G, Racila E, Stence A, Pruessner J, Forde S, Hackman J, Ma D, Heusel J, Bossler A.  Improved detection of the BRAF c.1799T >A (p.V600E) mutation in melanoma with a single nucleotide primer extension assay.  101st United States and Canadian Academy of Pathology’s Annual Meeting, Vancouver, BC, Canada.  2012. 

Savage J, Ma D, Caponetti G, Bossler A, Heusel J.  Microsatellite Instability Discordance in Synchronous Colorectal Adenocarcinoma—Evidence for Parallel Oncogenic Pathways involving Distinct Molecular Mechanisms.  American Association for Molecular Pathology Annual Meeting, Long Beach, CA.  2012. 

Ma D, Chen Z, Patel K, Mishra B, Yao H, Abruzzo L, Medeiros L, Wierda W, Keating M, Sargent R, Luthra R.  Array comparative genomic hybridization analysis identifies recurrent gain of chromosome 2p25.3 involving the ACP1 and MYCN genes in chronic lymphocytic leukemia.  Clinical lymphoma, myeloma & leukemia.  2011 June. 11 Suppl 1:S17-24.
[PubMed]

Ma D, Darling T, Moss J, Lee C.  Histologic variants of periungual fibromas in tuberous sclerosis complex.  Journal of the American Academy of Dermatology.  2011 February. 64(2):442-4.
[PubMed]

Ma D, Yao Y, Ziober A, Sepulveda A.  Characterization of an Lgr5-positive stem cell population in gastric cancer tissues and background gastric mucosa (452691).  100th United States and Canadian Academy of Pathology (USCAP) Annual Meeting, San Antonio, TX.  2011. 

Patel K, Barkoh B, Chen Z, Ma D, Reddy N, Medieros L, Luthra R.  Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia: An algorithmic approach using high resolution melting curve analysis.  Journal of molecular diagnostics.  2011. 13(6):678-86.
[PubMed]

Ma D, Chen Z, Cheng H, Djordevic B, Patel K, Luthra M, Medeiros L, Broaddus R, Luthra R.  Expression of microRNA-210 in microsatellite instability high endometrial carcinoma and its potential role in DNA damage repair (#452009).  100th United States and Canadian Academy of Pathology (USCAP) Annual Meeting, San Antonio, TX.  2011. 

Ma D, Luthra R, Chen S, Yin C, Sargent R, Patel K, Medeiros L, Zuo Z.  RAS Mutational analysis in 9334 solid and hematopoietic malignancies (#450126).  100th United States and Canadian Academy of Pathology (USCAP) Annual Meeting, San Antonio, TX.  2011. 

Ma D, Chen Z, Nero C, Patel K, Daoud E, Cheng C, Djordjevic B, Broaddus R, Mediros L, Rashid A, Luthra R.  Somatic deletions of the polyA tract in the 3′-UTR of EGFR are common in microsatellite instability-high endometrial and colorectal carcinomas.  American Association for Molecular Pathology Annual Meeting, Grapevine, TX.  2011. 

Patel K, Barkof B, Chen Z, Ma D, Medeiros L, Luthra R.  Testing for IDH1 and IDH2 Variants in Acute Myeloid Leukemia: An Analgorithmic Approach Using High Resolution Melting Curve Analysis (#1928).  100th United States and Canadian Academy of Pathology (USCAP) Annual Meeting, San Antonio, TX.  2011. 

Patel K, Ravandi F, Ma D, Paladugu A, Barkoh B, Medeiros L, Luthra R.  Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features.  American journal of clinical pathology.  2011 January. 135(1):35-45.
[PubMed]

Ma D, Djordjevic B, Patel K, Ao X, Barkoh B, Chen Z, Broaddus R, Luthra R.  Assessment of PTEN mutation detection by high resolution melting analysis (#194049).  American Association for Molecular Pathology Annual Meeting, San Jose, CA.  2010. 

Barkoh B, Ma D, Patel K, Manekia J, Luthra R.  Design and evaluation of a solid tumor mutation panel by sequenom MassARRAY system.  American Association for Molecular Pathology Annual Meeting, San Jose, CA.  2010. 

Patel K, Ravandi F, Ma D, Barkoh B, Yao H, Abraham R, Pierce S, Kantarjian H, Luthra R.  Detection of cytogenetic abnormalities associated with outcome differences in acute myeloid leukemia using array-based comparative genomic hybridization (aCGH) analysis.  Hematologic Malignancies Conference, Houston, TX.  2010. 

Ma D, Chen Z, Patel K, Mishra B, Yao H, Abruzzo L, Medeiros L, Wierda W, Keating M, Sargent R, Luthra R.  Gain of chromosome 2p25.3 involving the ACP1 gene is frequent in chronic lymphocytic leukemia (#103).  Hematologic Malignancies Conference, Houston, TX.  2010. 

Patel K, Ma D, Barkoh B, Yao H, Sargent R, Drakos H, Medeiros L, Luthra R.  MicroRNA profiling of anaplastic large cell lymphoma.  United States and Canadian Academy of Pathology (USCAP) Annual Meeting, Washington, DC.  2010. 

Ma D, Jones D.  Post-transplant Immune Function and the Development of Lymphoma.  Humana Press, New York.  2010. 

Patel K, Ravandi F, Ma D, Barkoh B, Paladugu A, Mishra B, Kantarjian H, Medeiros L, Luthra R.  The study of novel IDH1R132 mutations in acute myeloid leukemia.  United States and Canadian Academy of Pathology (USCAP) Annual Meeting, Washington, DC.  2010. 

Patel K, Ravandi F, Ma D, Yao H, Abraham R, Barkoh B, Pierce P, Kantarjian H, Luther R.  Detection of cytogenetic abnormalities associated with outcome differences in acute myeloid leukemia using array-based comparative genomic hybridization (aCGH) analysis.  Blood (ASH Annual Meeting Abstracts), 114: 1633.  2009. 

Ma D, Darling T, Moss J, Lee C.  Histological variants of periungual fibromas in fibrous sclerosis complex.  46th Annual Meeting of American Society for Dermatopathology, Chicago, IL.  2009. 

Kaetzel D, Zhang Q, Yang M, McCorkle J, Ma D, Craven R.  Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression.  Journal of bioenergetics and biomembranes.  2006 August. 38(4-Mar):163-7.
[PubMed]

Ma D, Nutt C, Shanehsaz P, Peng X, Louis D, Kaetzel D.  Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors.  Cancer research.  2005 July. 65(13):5523-34.
[PubMed]

Ma D, McCorkle J, Kaetzel D.  The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity.  The Journal of biological chemistry.  2004 April. 279(17):18073-84.
[PubMed]

Ma D, McCorkle J, Kaetzel D.  Characterization of NH23-H1 cleavage activity.  5th International Congress of Genetics, Biochemistry and Physiology of NM23/ND Kinase/Awd, Lexington, KY.  2003. 

Ma D, McCorkle J, Kaetzel D.  The metastasis suppressor NM23-H1 possesses a 3’-5’ exonuclease activity.  94th Annual Meeting of American Association for Cancer Research, Washington, DC.  2003. 

Ma D, Shanehsaz P, Kaetzel D.  Gene expression profile following interruption of a PDGF-driven autocrine loop in U87 glioblastoma cells. 93th Annual Meeting of American Association for Cancer Research(A70).  93th Annual Meeting of American Association for Cancer Research(A70), Proceedings of the American Association for Cancer Research, San Francisco, CA.  2002. 

Ma D, Xing Z, Liu B, Pedigo N, Zimmer S, Bai Z, Postel E, Kaetzel D.  NM23-H1 and NM23-H2 repress transcriptional activities of nuclease-hypersensitive elements in the platelet-derived growth factor-A promoter.  The Journal of biological chemistry.  2002 January. 277(2):1560-7.
[PubMed]

Kaetzel D, Ma D, Zhang H, Dugan A, Pedigo N.  Activity of a cell type-specific enhancer element in the 5’-distal region of the PDGF-A gene is modulated by Vit. D receptor/retinoid-X receptor heterodimers.  Special Session of the American Association for Cancer Research, “Molecular Biology and New Therapeutic Strategies”, Maui.  2001. 

Ma D, Xiang E, Zhang Q, Postel E, Kaetzel D.  NM23-H1 cleaves positive and negative regulatory sequences in the PDGF-A gene (#T12).  Proceedings of the Fourth International Congress of the Genetics, Biochemistry and Physiology of NDP kinase/ NM23/AWD, Tokyo Medical and Dental University, Japan.  2001. 

Ma D, Huang H, Moscow J.  Down-regulation of reduced folate carrier gene (RFC1) expression after exposure to methotrexate in ZR-75-1 breast cancer cells.  Biochemical and biophysical research communications.  2000 December. 279(3):891-7.
[PubMed]

Hong K, Ma D, Beverley S, Turco S.  The Leishmania GDP-mannose transporter is an autonomous, multi-specific, hexameric complex of LPG2 subunits.  Biochemistry.  2000 February. 39(8):2013-22.
[PubMed]

Ma D, Moscow J.  Effects of acute methotrexate exposure on reduced folate carrier RNA levels and activity.  Platform for mini-symposium, 90th Annual Meeting of American Association for Cancer Research. Proceedings of the American Association for Cancer Research, 40:195, Philadelphia, PA.  1999. 

Ma D, Russell D, Beverley S, Turco S.  Golgi GDP-mannose uptake requires Leishmania LPG2 - A member of a eukaryotic family of putative nucleotide-sugar transporters.  The Journal of biological chemistry.  1997 February. 272(6):3799-805.
[PubMed]

Ma D, Russell D, Beverley S, Turco S.  Leishmania LPG2, a putative GDP Man transporter is required for Golgi GDP-Man uptake.  Young Scientists’ Program and 17th International Congress of Biochemistry and Molecular Biology, FASEB Journal, 11 (no. 9): A1420, San Francisco, CA.  1997. 

Ma D, Beverley S, Turco S.  Leishmania donovani possess a NADPH-dependent alkylglycerol cleavage enzyme.  Biochemical and biophysical research communications.  1996 October. 227(3):885-9.
[PubMed]

 S, Ma D, Turco S.  New cellular pathways and compartments involved in the biosynthesis of the GPI-anchored virulence glycoconjugate, the Leishmania LPG.  24th Conference in Glycobiology Society for Glycobiology, Glycobiology, Boston, MA.  1996. 

Ma D, Beverley S, Turco S.  Partial characterization of a NADPH-dependent glyceryl ether monooxygenase in Leishmania donovani.  Annual Molecular Parasitology Meeting, Woods Hole, MA.  1995. 

Date Last Modified: 06/07/2014 - 21:56:23