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Director, Molecular Genetic Pathology FellowshipCo-Director, Resident Rotation in Molecular PathologyDirector, Molecular Pathology LaboratoryDirector, Molecular Infectious Disease SectionClinical Associate Professor of Pathology
- Clinical Pathology
Primary Office: C606 General HospitalIowa City, IA 52242
Primary Office Phone: 319-384-9566
BA, Biochemistry, Columbia University, New York City, NYMD, Medical Scientist Training Program and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IAPhD, Medical Scientist Training Program and Molecular Biology, University of Iowa Carver College of Medicine, Iowa City, IA
Residency, Clinical Pathology, University of Iowa Carver College of Medicine, Iowa City, IAFellowship, Molecular Genetic Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA
Diplomat in Molecular Genetic Pathology, American Board of PathologyDiplomat in Clinical Pathology, American Board of Pathology
Dr. Bossler's clinical service duties include directing the molecular pathology laboratory, developing and validating new, rapid, and cost effective molecular assays for genetic, neoplastic and infectious disease testing, and interpreting and reporting patient results from clinical molecular testing. His research interest is in understanding the mechanisms and pathways which lead to oncogenesis particularly regarding the association of infection with high risk human papillomavirus (HPV) and the development of squamous cell cancer.
Evaluation of the Bruker Biotyper and Vitek MS matrix-assisted laser desorption ionization-time of flight mass spectrometry systems for identification of nonfermenting gram-negative bacilli isolated from cultures from cystic fibrosis patients.
Journal of clinical microbiology.
Performance of the COBAS® AmpliPrep/COBAS TaqMan® automated system for hepatitis C virus (HCV) quantification in a multi-center comparison.
Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology.
FSH dystrophy and a subtelomeric 4q haplotype: a new assay and associations with disease.
Journal of medical genetics.
Journal of clinical neuromuscular disease.
Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs.
Journal of virology.
Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway.
Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1.
The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth.
Journal of virology.
Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells.
Head & neck.
Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma.
Journal of immunotherapy.
Date Last Modified: 01/30/2013 -
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