Pathology

Gary L. Baumbach, MD

Portrait

Professor of Pathology  - Anatomic Pathology

Contact Information

Primary Office: 5231-C Roy Carver Pavilion
Iowa City, IA 52242
Primary Office Phone: 319-384-9083

Email: g-baumbach@uiowa.edu

Education

BA, Wartburg College, Waverly, IA
MD, University of Iowa, Iowa City, IA

Externship, Pathology, University of Iowa Hospitals & Clinics
Residency, Pathology, University of Iowa Hospitals & Clinics
Residency, Ophthalmology, University of Iowa Hospitals & Clinics
Fellowship, Cardiovascular Research/Neuropathology , University of Iowa Hospitals & Clinics
Fellowship, Neuropathology , University of Iowa Hospitals & Clinics

Licensure and Certifications

State of Iowa Medical License Iowa Board of Medicine
Neuropathology Special Qualification in Neuropathology American Board of Pathology
Opthalmology American Board of Ophthalmology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Informatics

Research Summary

The long-term objective of studies in our laboratory is to clarify the relationship between morphology and function of blood vessels in the brain, and to understand the influence of structural changes produced by chronic hypertension and aging on function of the vessel wall. To achieve these goals, in vivo and in vitro methods are used to analyze cerebral vascular mechanics, and morphometric methods to quantitate components of the vessel wall. Hypotheses that are currently being tested include: 1) that contraction of smooth muscle in cerebral arterioles is augmented in early hypertension, prior to the development of vascular hypertrophy, and contraction may be affected by structural alterations that develop during prolonged hypertension, 2) that effects of chronic hypertension on smooth muscle contraction may be different with respect to vessel size and brain region, and 3) that effects of aging on structure and function of blood vessels in the brain may be similar, in some respects, to effects of chronic hypertension. In addition to these interests, our laboratory has recently undertaken a new direction with the aim of extending studies of vascular mechanics and structure to the cellular level. Initial efforts have focused on the use of confocal microscopy and computer-assisted image analysis to examine effects of mechanical deformation on focal and near contacts (focal adhesion sites) in vascular smooth muscle in tissue culture. Focal contacts provide anchorage sites essential for the maintenance of tension within the cell, and are involved in regulation of cell morphology, proliferation, migration, differentiation and responsiveness. It is anticipated that these studies will lead to greater understanding of the fundamental mechanisms that are involved in structural changes in the vessel wall as related to increases in mechanical stress that accompany chronic hypertension and aging.

Selected Publications

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Baumbach G, Rodionov R, Dayoub H, Lynch C, Wilson K, Stevens J, Murry D, Kimoto M, Arning E, Bottiglieri T, Cooke J, Baumbach G, Faraci F, Lentz S.  Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.  Circulation research.  2010 February. 106(3):551-8.
[PubMed]

Grigoryan M, Geisler S, St Louis E, Baumbach G, Davis P.  Cerebral arteriolar thromboembolism in idiopathic hypereosinophilic syndrome.  Archives of neurology.  2009 April. 66(4):528-31.
[PubMed]

Wakisaka Y, Miller J, Chu Y, Baumbach G, Wilson S, Faraci F, Sigmund C, Heistad D.  Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage.  Journal of cerebral blood flow and metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism.  2008 June. 28(6):1175-85.
[PubMed]

Baumbach G, Beyer A, Baumbach G, Halabi C, Modrick M, Lynch C, Gerhold T, Ghoneim S, de Lange W, Keen H, Tsai Y, Maeda N, Sigmund C, Faraci F.  Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling.  Hypertension.  2008 April. 51(4):867-71.
[PubMed]

Baumbach G, Didion S, Faraci F.  Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase.  Stroke; A Journal of Cerebral Circulation.  2006 July. 37(7):1850-5.
[PubMed]

Iida S, Baumbach G, Lavoie J, Faraci F, Sigmund C, Heistad D.  Spontaneous stroke in a genetic model of hypertension in mice.  Stroke; A Journal of Cerebral Circulation.  2005 June. 36(6):1253-8.
[PubMed]

Didion S, Lynch C, Baumbach G, Faraci F.  Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes.  Stroke; A Journal of Cerebral Circulation.  2005 February. 36(2):342-7.
[PubMed]

Baumbach G, Sigmund C, Faraci F.  Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase.  Circulation research.  2004 October. 95(8):822-9.
[PubMed]

Chillon J, Baumbach G.  Effects of indapamide, a thiazide-like diuretic, on structure of cerebral arterioles in hypertensive rats.  Hypertension.  2004 May. 43(5):1092-7.
[PubMed]

Baumbach G.  Effects of angiotensin-converting enzyme inhibitors on cerebral vascular structure in chronic hypertension.  J Hyperten.  2000. 18 Supp.:S7-S11.

Date Last Modified: 06/12/2014 - 07:32:37