Pathology

Andrean Simons-Burnett, PhD

Portrait

Assistant Professor of Pathology

Contact Information

Primary Office: 1161 Medical Laboratories
Iowa City, IA 52242
Primary Office Phone: 319-384-4450

Email: andrean-simons@uiowa.edu
Web: Dr. Simons-Burnett's Research Laboratory

Education

Michigan Technology University, Houghton, MI
BS, Biochemistry, Iowa State University, Ames, IA
PhD, Toxicology and Food Science and Technology, Iowa State University, Ames, IA

Post Doctoral, Free Radical and Radiation Biology, University of Iowa, Carver College of Medicine

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Human Toxicology

Research Summary

Signaling pathways and oxidative stress in cancer progression.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Selected Publications

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Du J, Nelson E, Simons-Burnett A, Olney K, Moser J, Schrock H, Wagner B, Buettner G, Smith B, Teoh M, Tsao M, Cullen J.  Regulation of pancreatic cancer growth by superoxide.  Molecular carcinogenesis.  2013. 52(7):555-67.
[PubMed]

Kang M, So E, Simons-Burnett A, Spitz D, Ouchi T.  DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.  Cell death & disease.  2012. 3:e249.
[PubMed]

Sobhakumari A, Love-Homan L, Fletcher E, Martin S, Parsons A, Spitz D, Knudson C, Simons-Burnett A.  Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism.  PLoS One.  2012. 7(10).
[PubMed]

Orcutt K, Parsons A, Sibenaller Z, Scarbrough P, Zhu Y, Sobhakumari A, Wilke W, Kalen A, Goswami P, Miller F, Spitz D, Simons-Burnett A.  Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.  Cancer research.  2011 June. 71(11):3932-40.
[PubMed]

Simons-Burnett A, Mattson D, Dornfeld K, Spitz D.  Glucose deprivation-induced metabolic oxidative stress and cancer therapy.  Journal of cancer research and therapeutics.  2009 September. 5 Suppl 1:S2-6.
[PubMed]

Fath M, Diers A, Aykin-Burns N, Simons-Burnett A, Hua L, Spitz D.  Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells.  Cancer biology & therapy.  2009 July. 8(13):1228-36.
[PubMed]

Simons-Burnett A, Parsons A, Foster K, Orcutt K, Fath M, Spitz D.  Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells.  Journal of Oncology.  2009. 2009:519563.
[PubMed]

Mattson D, Ahmad I, Dayal D, Parsons A, Aykin-Burns N, Li L, Orcutt K, Spitz D, Dornfeld K, Simons-Burnett A.  Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism.  Free radical biology & medicine.  2009 January. 46(2):232-7.
[PubMed]

Simons-Burnett A, Fath M, Mattson D, Smith B, Walsh S, Graham M, Hichwa R, Buatti J, Dornfeld K, Spitz D.  Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging.  International journal of radiation oncology, biology, physics.  2007 November. 69(4):1222-30.
[PubMed]

Simons-Burnett A, Ahmad I, Mattson D, Dornfeld K, Spitz D.  2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells.  Cancer research.  2007 April. 67(7):3364-70.
[PubMed]

Date Last Modified: 07/31/2013 - 10:51:40