Ophthalmology And Visual Sciences

Vinit B. Mahajan, MD, PhD

Portrait

Assistant Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 11190E PFP
Iowa City, IA 52242
Primary Office Phone: 319-356-8161

Lab: 4166 MERF
Iowa City, IA 52242
Phone: 319-384-1700

Email: vinit-mahajan@uiowa.edu
Web: Mahajan Laboratory

Education

BA, Molecular and Cell Biology, University of California
MD, NIH Medical Scientist Training Program, University of California, Irvine
PhD, NIH Medical Scientist Training Program, University of California

Internship, Transitional , Harbor-UCLA Medical Center
Residency, Ophthalmology, University of California Los Angeles
Fellowship, Vitreoretinal Diseases and Surgery, University of Iowa

Licensure and Certifications

Iowa Medical License Iowa Board of Medicine

Research Summary

My career goal is to understand and discover new treatments for vitreoretinal disease. My passion and core belief is that the delivery of molecular genetic therapeutics for vitreoretinal disease can be accelerated into the clinic and operating room by translational research teams of clinicians and scientists.

All Publications

Chen J, Ingham N, Kelly J, Jadeja S, Goulding D, Pass J, Mahajan V, Tsang S, Nijnik A, Jackson I, White J, Forge A, Jagger D, Steel K.  Spinster homolog 2 (Spns2) deficiency causes early onset progressive hearing loss.  PLoS Genet.  2014 October. 10(10):e1004688.
[Link]

Marsiglia M, Mahajan V, Lee W, Tsang S, Delori F, Sparrow J.  Quantitative Autofluorescence as a Clinical Tool for Expedited Differential Diagnosis of Retinal Degenerations.  Jama Ophthalmol.  2014 September 19. 

Nelson N, Skeie J, Muradov H, Rowell H, Seo S, Mahajan V.  CAPN5 gene silencing by short hairpin RNA interference.  BMC Research.  2014 September 9. 

Almeida D, Chin E, Mears K, Russell S, Mahajan V.  Spontaneous dislocation of a fluocinolone acetonide implant (Retisert) into the anterior chamber and its successful extraction in sympathetic ophthalmia.  Retinal Cases & Brief Reports.  2014 August 22. 

Skeie J, Mahajan V.  Proteomic Landscape of the Human Choroid-Retinal Pigment Epithelial Complex.  JAMA Ophthalmol.  2014 July 24. 

Effect of ocriplasmin on the management of macular holes: assessment of the clinical relevance of ocriplasmin. , Mahajan V, et al. .  JAMA Ophthomal.  2014 June. 

Bassuk A, Sujirakul T, Tsang S, Mahajan V.  A novel RPGR mutation masquerading as Stargardt disease.  Br J Ophthalmol;  2014. 

Chen J, Sohn E, Folk J, Mahajan V, Kay C, Boldt H, Russell S.  Decreased macular thickness in nonproliferative macular telangiectasia type 2 with oral carbonic anhydrase inhibitors.  Retina.  2014. 34(7):1400-06.
[PubMed]

Sowers L, Yin T, Mahajan V, Bassuk A.  Defective motile cilia in prickle2-deficient mice.  J Neurogenet.  2014. 28(1-2):146-152.
[PubMed]

Sowers L, Yin T, Mahajan V, Bassuk A.  Defective motile cilia in Prickle2-deficient mice.  J Neurogenet.  2014. 28(1-2):146-52.
[PubMed]

Wert K, Skeie J, Olivier A, Tsang S, Mahajan V.  Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina.  Hum Mol Genet. ;  2014. 

Skeie J, Mahajan V.  Proteomic Interactions in the Mouse Vitreous-Retina Complex .  PLOS One.  2013 October 22. 8(11):e82140.
[PubMed]

Paemka L, Mahajan V, Skeie J, Sowers L, Ehaideb S, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro B, Ferguson P, Pieper A, Britt J, Wemmie J, Rudd D, Wassink T, El-Shanti H, Mefford H, Carvill G, Manak J, Bassuk A.  PRICKLE1 interaction with SYNAPSIN I reveals a role in Autism Spectrum Disorders.  PLoS One.  2013 October. 8(12):e80737.
[PubMed]

Skeie J, Tsang S, Vande Zande R, Fickbohm M, Shah S, Vallone J, Mahajan V.  A biorepository for ophthalmic surgical specimens.  Proteomics Clinical Applications;  2013. 

Mahajan V, Skeie J.  Translational vitreous proteomics.  Proteomics Clinical Applications;  2013. 

White J, Gerdin A, Karp N, Ryder E, Buljan M, Bussell J, Salisbury J, Clare S, Ingham N, Podrini C, Houghton R, Estabel J, Bottomley J, Melvin D, Sunter D, Adams N,  , Tannahill D, Logan D, Macarthur D, Flint J, Mahajan V, Tsang S, Smyth I, Watt F, Skarnes W, Dougan G, Adams D, Ramirez-Solis R, Bradley A, Steel K.  Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes.  Cell.  2013 July. 154(2):452-464.
[Link]

Tlucek P, Folk J, Sobol W, Mahajan V.  Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy..  Clin Ophthalmology.  2013 June 10. 7:1093-1098.
[PubMed]

Tozer K, Roller A, Chong L, Sadda S, Folk J, Mahajan V, Russell S, Boldt H, Sohn E.  Combination Therapy for Neovascular Age-Related Macular Degeneration Refractory to Anti-Vascular Endothelial Growth Factor Agents.  Ophthalmology.  2013 May 25. 120(10):2029-34.
[PubMed]

Darbro B, Mahajan V, Gakhar L, Skeie J, Campbell E, Wu S, Bing X, Millen K, Dobyns W, Kessler J, Jalali A, Cremer J, Segre A, Manak J, Aldinger K, Suzuki S, Natsume N, Ono M, Hai H, Viet le T, Loddo S, Valente E, Bernardini L, Ghonge N, Ferguson P, Bassuk A.  Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles.  Human Mutation.  2013 May 14. 34(8):1075-1079.
[Link]

Chen J, Ingham N, Clare S, Raisen C, Vancollie V, Ismail O, McIntyre R, Tsang S, Mahajan V, Dougan G, Adams D, White J, Steel K.  Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media.  PLoS One.  2013 March 13. 8(3):e58156.
[PubMed]

Bakall B, Folk J, Boldt H, Sohn E, Stone E, Russell S, Mahajan V.  Aflibercept Therapy for Exudative Age-related Macular Degeneration Resistant to Bevacizumab and Ranibizumab.  Am J Ophthalmol.  2013. 156(1):15-22.
[Link]

Chen J, Ingham N, Clare S, Raisen C, Vancollie V, Ismail O, McIntyre R, Tsang S, Mahajan V, Dougan G, Adams D, White J, Steel K.  Correction: MCPH-1 Deficient Mice Reveal a Role for MCPH1 in Otitis Media.  PLoS One.  2013. 8(6).
[PubMed]

Chen J, Sohn E, Folk J, Mahajan V, Kay C, Boldt H, Russell S.  Decreased Macular Thickness in Non-Proliferative MacTel type II with Oral Carbonic Anhydrase Inhibitors.  Retina.  2013. 

Mahajan V, Lin J.  Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy.  Clin Ophthalmology.  2013. 7:1339-1345.
[Link]

Tarantola R, Tsui J, Graff J, Russell S, Boldt H, Mahajan V, Folk J.  Intraoperative sclerotomy-related retinal breaks during 23-gauge pars plana vitrectomy.  Retina.  2013 January. 33(1):136-142.
[Link]

Cunningham M, Tarantola R, Folk J, Sohn E, Boldt H, Graff J, Elkins K, Russell S, Mahajan V.  Proliferative Vitreoretinopathy may be a risk factor in combined macular hole retinal detachment cases.  Retina.  2012 December 7. 33(3):579-85.
[Link]

Rowell H, Bassuk A, Mahajan V.  Monozygotic twins with CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy.  Clin Ophthalmology.  2012 December 6. 6:2037-2044.
[Link]

Russell S, Sohn E, Boldt H, Folk J, Tarantola R, Kay C, Mahajan V.  Elimination of Infusion Bubbles and Uncontrolled Reflux in the Alcon Constellation Vitrectomy Vision System.  Retina.  2012 December. 33(4):803-6.
[Link]

Skeie J, Brown E, Martinez H, Russell S, Birkholz E, Folk J, Boldt H, Gehrs K, Stone E, Wright M, Mahajan V.  Proteomic analysis of vitreous biopsy techniques.  Retina.  2012 November. 32(10):2141-2149.
[Link]

Wert K, Skeie J, Davis R, Tsang S, Mahajan V.  Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye.  J Vis Exp.  2012 November. 25(69):pii: 4286. doi: 10.3791/4286..
[Link]

Mahajan V, Skeie J, Bassuk A, Fingert J, Braun T, Daggett H, Folk J, Sheffield V, Stone E.  Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration..  PLoS Genet.  2012 October. 8(10): e1003001.
[Link]

Tarantola R, Graff J, Somani R, Mahajan V.  Temporal approach for small-gauge pars plana vitrectomy combined with anterior segment surgery..  Retina.  2012 September. 32(8):1614-1623.
[Link]

Davis A, Folk J, Russell S, Sohn E, Boldt H, Stone E, Mahajan V.  Intravitreal bevacizumab for peripapillary choroidal neovascular membranes..  Arch Ophthalmology.  2012 August 1. 130(8):1073-1075.
[Link]

Tlucek P, Folk J, Orien J, Stone E, Mahajan V.  Inhibition of Neovascularization but Not Fibrosis With the Fluocinolone Acetonide Implant in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy..  Arch Ophthalmol.  2012 July 9. 130(11):1395-401.
[Link]

Kay C, Quiram P, Mahajan V.  23-gauge pediatric vitrectomy using limbus-based trocar-cannulas..  Retina.  2012 May. 32(5):1023-1027.
[Link]

Xu L, Burke T, Greenberg J, Mahajan V, Tsang S.  Infrared imaging and optical coherence tomography reveal early-stage astrocytic hamartomas not detectable by fundoscopy..  Am J Ophthalmology.  2012 May. 153(5):883-889 e2.
[Link]

Tarantola R, Mahajan V.  Intraoperative choroidal detachment during 23-gauge vitrectomy.  Retina.  2012 February. 32(2):411.

Tarantola R, Mahajan V.  Correspondence [re: "Intraoperative choroidal detachment during 23-gauge vitrectomy"].  Retina.  2012. 32(2):411.
[PubMed]

McIntyre R, Lakshminarasimhan C, Ismail O, Carragher D, Sanchez-Andrade G, Forment J, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Wang F, Sanger Mouse Genetics Project , Ramirez-Solis R, Estabel J, Gallagher F, Logan D, Arends M, Tsang S, Mahajan V, Scudamore C, White J, Jackson S, Gergely F, Adams D.  Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.  PLoS Genet.  2012. 8(11):e1003022. doi: 10.1371.
[Link]

Quellec G, Russell S, Seddon J, Reynolds R, Scheetz T, Mahajan V, Stone E, Abramoff M.  Automated Discovery and Quantification of Image based Complex Phenotypes: a Twin Study of Drusen Phenotypes in Age-related Macular Degeneration.  Invest. Ophthalmol. Vis. Sci. .  2011 November 25. 52(12):9195-9206.
[Link]

Mahajan V, Skeie J, Assefnia A, Mahajan M, Tsang S.  Mouse eye enucleation for remote high-throughput phenotyping.  J Vis Exp..  2011 November. 19(57):online at http://www.jove.com/video/3184/mouse-eye-enucleation-for-remote-high-throughput-phenotyping.
[Link]

Roller A, Folk J, Patel N, Boldt H, Russell S, Abramoff M, Mahajan V.  Intravitreal bevacizumab for treatment of proliferative and nonproliferative type 2 idiopathic macular telangiectasia.  Retina.  2011 October. 31(9):1848-1855.
[Link]

Kay C, Tarantola R, Gehrs K, Folk J, Mahajan V, Boldt H, Syed N, Russell S.  Uveitis Following Intravitreal Bevacizumab: A Non-Infectious Cluster.  Ophthalmic Surg Lasers Imaging.  2011 August. 42(4):292-296.
[Link]

Tarantola R, Folk J, Shah S, Boldt H, Abràmoff M, Russell S, Mahajan V.  Intraoperative choroidal detachment during 23-gauge vitrectomy.  Retina.  2011 May. 31(5):893-901.
[Link]

Mahajan V, Tarantola R, Graff J, Boldt H, Abramoff M, Russell S, Folk J.  Sutureless triplanar sclerotomy for 23-gauge vitrectomy.  Arch Ophthalmol.  2011 May. 129(5):585-590.
[Link]

Skeie J, Tsang S, Mahajan V.  Evisceration of mouse vitreous and retina for proteomic analyses.  J Vis Exp.  2011 April 3. null(50):2795.
[Link]

Ko A, Brinton J, Mahajan V, Zimmerman B, Brinton G, Stone E, Folk J, Mullins R.  Seroreactivity against aqueous-soluble and detergent-soluble retinal proteins in posterior uveitis.  Arch Ophthalmol.  2011 April. 129(4):415-420.
[Link]

Tao H, Manak J, Sowers L, Mei X, Kiyonari H, Abe T, Dahdaleh N, Yang T, Wu S, Chen S, Fox M, Gurnett C, Montine T, Bird T, Shaffer L, Rosenfeld J, McConnell J, Madan-Khetarpal S, Berry-Kravis E, Griesbach H, Saneto R, Scott M, Antic D, Reed J, Boland R, Ehaideb S, El-Shanti H, Mahajan V, Ferguson P, Axelrod J, Lehesjoki A, Fritzsch B, Slusarski D, Wemmie J, Ueno N, Bassuk A.  Mutations in prickle orthologs cause seizures in flies, mice, and humans.  Am J Hum Genet.  2011 February 11. 88(2):138-149.
[Link]

Skeie J, Mahajan V.  Dissection of human vitreous body elements for proteomic analysis.  J Vis Exp.  2011 January 23. 
[Link]

Mahajan V, Elkins K, Russell S, Boldt H, Gehrs K, Weingeist T, Stone E, Abramoff M, Lui D, Folk J.  Bilateral intravitreal injection of antivascular endothelial growth factor therapy.  Retina.  2011 January. 31(1):31-35.
[Link]

Mahajan V, Olney A, Garrett P, Chary A, Dragan E, Lerner G, Murray J, Bassuk A.  Collagen XVIII mutation in Knobloch syndrome with acute lymphoblastic leukemia.  Am J Med Genet A.  2010 November. 152A(11):2875-2879.
[Link]

Tarantola R, Folk J, Boldt H, Mahajan V.  Intravitreal bevacizumab during pregnancy.  Retina.  2010 October. 30(9):1405-1411.
[Link]

Mahajan V, Stone E.  Patients with an acute zonal occult outer retinopathy-like illness rapidly improve with valacyclovir treatment.  Am J Ophthalmology.  2010 October. 150(4):511-518.
[Link]

Roller A, Mahajan V, Boldt H, Abramoff M, Russell S, Folk J.  Effects of vitrectomy on age-related macular degeneration.  Ophthalmology.  2010 July. 117(7):1381-1386.
[Link]

Mahajan V, Vallone J, Lin J, Mullins R, Ko A, Folk J, Stone E.  T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy.  Mol Vis.  2010 June 8. 16:1034-1040.
[Link]

Abramoff M, Reinhardt J, Russell S, Folk J, Mahajan V, Niemeijer M, Quellec G.  Automated early detection of diabetic retinopathy.  Ophthalmology.  2010 June. 117(6):1147-1154.
[Link]

Mahajan V, Russell S, Stone E.  A new macular dystrophy with anomalous vascular development, pigment spots, cystic spaces, and neovascularization.  Archives of Ophthalmology.  2009 November. 127(11):1449-1457.
[Link]

Shah S, Tsang S, Mahajan V.  Erythropoetin receptor expression in the human diabetic retina.  BMC Res Notes.  2009 November. 2:234.
[Link]

Mahajan V, Folk J, Boldt H.  A head-tilt test for hypopyon after intravitreal triamcinolone.  Retina.  2009 April. 29(4):560-561.
[Link]

Mahajan V, Gehrs K, Goldstein D, Fischer D, Lopez J, Folk J.  Management of sympathetic ophthalmia with the fluocinolone acetonide implant.  Ophthalmology.  2009 March. 116(3):552-557.
[Link]

Seitzman R, Mahajan V, Mangione C, Cauley J, Ensrud K, Stone K, Cummings S, Hochberg M, Hillier T, Sinsheimer J, Yu F, Coleman A.  Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older women.  Am J Epidemiol.  2008 May 15. 167(10):1217-25.
[Link]

Tsang S, Woodruff M, Jun L, Mahajan V, Yamashita C, Pedersen R, Lin C, Goff S, Rosenberg T, Larsen M, Farber D, Nusinowitz S.  Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness.  Hum Mutat.  2007 March. 28(3):243-254.
[Link]

Sok J, Kuriakose M, Mahajan V, Pearlman A, DeLacure M, Chen F.  Tissue-specific gene expression of head and neck squamous cell carcinoma in vivo by complementary DNA microarray analysis.  Arch Otolaryngol Head Neck Surg.  2003 July. 129(7):760-770.
[Link]

Mahajan V, Wei C, McDonnell P.  Microarray analysis of corneal fibroblast gene expression after interleukin-1 treatment.  Invest Ophthalmol Vis Sci.  2002 July. 43(7):2143-2151.
[Link]

Pai K, Mahajan V, Lau A, Cunningham D.  Thrombin receptor signaling to cytoskeleton requires Hsp90.  J Biol Chem.  2001 August 31. 276(35):32642-32647.
[Link]

Mahajan V, Pai K, Lau A, Cunningham D.  Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton.  Proc Natl Acad Sci USA.  2000 October 24. 97(22):12062-12067.
[Link]

Nose A, Mahajan V, Goodman C.  Connectin, a homophilic cell adhesion molecule them in drosophilia.  Cell.  1992 August 21. 70(4):553-567.
[Link]

Date Last Modified: 06/07/2014 - 21:56:23