Ophthalmology And Visual Sciences

Seongjin Seo, PhD

Portrait

Assistant Professor of Ophthalmology and Visual Sciences

Contact Information

Office: 4135F MERF
Iowa City, IA 52242
Office Phone: 319-353-4605

Lab: 4171 MERF
Iowa City, IA 52242

Email: seongjin-seo@uiowa.edu

Education

BS, Biology Education, Seoul National University
MEd, Biology, Seoul National University
PhD, Molecular Biology and Pharmacology, Washington University School of Medicine

Center, Program and Institute Affiliations

Stephen A. Wynn Institute for Vision Research

All Publications

Zhang Y, Seo S, Bhattarai S, Bugge K, Searby C, Zhang Q, Drack A, Stone E, Sheffield V.  BBS mutations modify phenotypic expression of CEP290-related ciliopathies.  Hum Mol Genet.  2014. 23(1):40-51.
[PubMed]

Sinha S, Belcastro M, Datta P, Seo S, Sokolov M.  Essential Role of the Chaperonin CCT in Rod Outer Segment Biogenesis.  Invest Ophthalmol Vis Sci.  2014. 55(6):3775-85.
[PubMed]

Chamling X, Seo S, Searby C, Kim G, Slusarski D, Sheffield V.  The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome.  PLoS One.  2014. 2:e1004083.
[PubMed]

Seo S, Solivan-Timpe F, Roos B, Robin A, Stone E, Kwon Y, Alward W, Fingert J.  Identification of Proteins that Interact with TANK Binding Kinase 1 and Testing for Mutations Associated with Glaucoma.  Curr. Eye. Res..  2013 February. 38(2):310-5.
[Link]

Chamling X, Seo S, Bugge K, Searby C, Guo D, Drack A, Rahmouni K, Sheffield V.  Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice.  PLoS One.  2013. 8(3):e59101.
[PubMed]

Drack A, Mullins R, Seo S.  Retinitis Pigmentosa Syndromes: Bardet-Biedl Syndrome.  Lippincott.  2013. 

Seo S, Mullins R, Dumitrescu A, Bhattarai S, Gratie D, Wang K, Stone E, Sheffield V, Drack A.  Subretinal gene therapy of mice with Bardet-Biedl syndrome type 1.  Invest Ophthalmol Vis Sci.  2013. 54(9):6118-32.
[PubMed]

Carter C, Vogel T, Zhang Q, Seo S, Swiderski R, Moninger T, Cassell M, Thedens D, Keppler-Noreuil K, Nopoulos P, Nishimura D, Searby C, Bugge K, Sheffield V.  Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.  Nat. Med..  2012 December. 18(12):1797-804.
[Link]

Humbert M, Weihbrecht K, Searby C, Li Y, Pope R, Sheffield V, Seo S.  ARL13B, PDE6D and CEP164 form a functional network for INPP5E ciliary targeting..  Proc. Natl. Acad. Sci. USA..  2012 November 27. 109(48):19691-6.
[Link]

Zhang Q, Yu D, Seo S, Stone E, Sheffield V.  Intrinsic protein-protein interaction mediated and chaperonin assisted sequential assembly of a stable Bardet-Biedl syndrome protein complex, the BBSome..  J Biol Chem.  2012 April 12. 287(24):20625-20635.
[Link]

Zhang Q, Seo S, Bugge K, Stone E, Sheffield V.  BBS proteins interact genetically with the IFT pathway to influence SHH related phenotypes..  Hum Mol Genet.  2012 January 6. 21(9):1945-1953.
[Link]

Zhang Q, Nishimura D, Seo S, Vogel T, Morgan D, Searby C, Bugge K, Stone E, Rhamouni K, Sheffield V.  Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS associated phenotypes and Bbs3 unique phenotypes..  Proc. Natl. Acad. Sci. USA..  2011 December 2. 108(51):20678-20683.
[Link]

Seo S, Zhang Q, Bugge K, Breslow D, Searby C, Nachury M, Sheffield V.  A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened..  PLoS Genet.  2011 November 3. 7(11):e1002358.
[Link]

Sang L, Miller J, Corbit K, Giles R, Brauer M, Otto E, Baye L, Wen X, Scales S, Kwong M, Huntzicker E, Sfakianos M, Sandoval W, Bazan J, Kulkarmi P, Giarcia-Gonzalo F, Seol A, O'Toole J, Held S, Reutter H, Lane W, Rafiq M, Noor A, Ansar M, Devi A, Sheffield V, Slusarski D, Vincent J, Doherty D, Hildebrandt F, Reiter J, Jackson P.  Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways.  Cell.  2011. 145(4):513-28.
[PubMed]

Seo S, Baye L, Schulz N, Beck J, Zhang Q, Slusarski D, Sheffield V.  BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.  Proc Natl Acad Sci U S A.  2010 January 26. 107(4):1488-93.
[Link]

Seo S, Guo D, Bugge K, Morgan D, Rahmouni K, Sheffield V.  Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling.  Hum Mol Genet.  2009 April 1. 18(7):1323-31.
[Link]

Rahmouni K, Fath M, Seo S, Thedens D, Berry C, Weiss R, Nishimura D, Sheffield V.  Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome.  J Clin Invest.  2008 April. 118(4):1458-67.
[Link]

Seo S, Lim J, Yellajoshyula D, Chang L, Kroll K.  Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers.  EMBO J.  2007 December 12. 26(24):5093-108.
[Link]

Seo S, Kroll K.  Geminin's double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation.  Cell Cycle.  2006 February. 5(4):374-9.
[Link]

Seo S, Herr A, Lim J, Richardson G, Richardson H, Kroll K.  Geminin regulates neuronal differentiation by antagonizing Brg1 activity.  Genes Dev.  2005 July 15. 19(14):1723-34.
[Link]

Seo S, Richardson G, Kroll K.  The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.  Development.  2005 January. 132(1):105-15.
[Link]

Seo S, Kang S, Cho G, Rho H, Jung G.  C/EBP Alpha and C/EBP Beta Play Similar Roles in the Transcription of the Human Cu/Zn SOD Gene.  Gene.  1997. 203(1):11-15.

Cho G, Kang S, Seo S, Kim Y, Jung G.  The Transcriptional Repression of the Human Cu/Zn Superoxide Dismutase (sod1) Gene by the Anticancer Drug Mitomycin C (MMC).  Biochem Mol Biol Int.  1997. 42(5):949-956.

Seo S, Kim H, Cho G, Rho H, Jung G.  Sp1 and C/EBP-Related Factor Regulate the Transcription of Human Cu/ZN SOD Gene.  Gene.  1996. 178(1-2):177-185.

Date Last Modified: 06/07/2014 - 21:56:23