Ophthalmology And Visual Sciences

Todd E. Scheetz, MS, PhD


Associate Professor of Ophthalmology and Visual Sciences
Associate Professor of Biomedical Engineering

Contact Information

Primary Office: 5015  SC
Iowa City, IA 52242
Primary Office Phone: 319-335-6054

Email: todd-scheetz@uiowa.edu


BS, Electrical Engineering, University of Iowa
MS, Electrical and Computer Engineering, University of Iowa
PhD, Genetics, University of Iowa

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Neuroscience

Research Summary

I am a trained bioinformaticist and geneticist. A major focus of my lab is the utilization and analysis of next-generation sequencing technology. We have identified two novel disease-causing genes to date, and are currently pursing validation in several additional families. I have a broad background in bioinformatics, with specific training and expertise in genetics and genomics. My PhD research focused on the large-scale gene discovery and mapping project in rat. Since then, my research projects have focused on genome-scale analysis of sequences and expression data

Center, Program and Institute Affiliations

Center for Bioinformatics and Computational Biology
Holden Comprehensive Cancer Center
Iowa Initiative in Human Genetics
Iowa Institute for Biomedical Imaging
John and Marcia Carver Nonprofit Genetic Testing Laboratory
Stephen A. Wynn Institute for Vision Research

All Publications

McGrail M, Hatler J, Kuang X, Liao H, Nannapaneni K, Watt K, Uhl J, Largaespada D, Vollbrecht E, Scheetz T, Dupuy A, Hostetter J, Essner J.  Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.  PLoS One.  2011 April 21. 6(4):e18826.

Zheng J, Miller K, Yang T, Hildebrand M, Shearer A, DeLuca A, Scheetz T, Drummond J, Scherer S, Legan P, Goodyear R, Richardson G, Cheatham M, Smith R, Dallos P.  Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).  Proc Natl Acad Sci U S A.  2011 March 8. 108(10):4218-23.

Ramachandran S, Clarke L, Scheetz T, Amaral M, McCray P.  Microarray mRNA expression profiling to study cystic fibrosis.  Methods Mol Biol.  2011. 742:193-212.

Brett B, Berquam-Vrieze K, Nannapaneni K, Huang J, Scheetz T, Dupuy A.  Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors.  PLoS One.  2011. 6(9):e24668.

Pezzulo A, Starner T, Scheetz T, Traver G, Tilley A, Harvey B, Crystal R, McCray P, Zabner J.  The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia.  Am J Physiol Lung Cell Mol Physiol.  2011 January. 300(1):L25-31.

Stone E, Cideciyan A, Aleman T, Scheetz T, Sumaroka A, Ehlinger M, Schwartz S, Fishman G, Traboulsi E, Lam B, Fulton A, Mullins R, Sheffield V, Jacobson S.  Variations in NPHP5 in patients with nonsyndromic leber congenital amaurosis and Senior-Loken syndrome.  Arch Ophthalmol.  2011 January. 129(1):81-7.

Shearer A, DeLuca A, Hildebrand M, Taylor K, Gurrola J, Scherer S, Scheetz T, Smith R.  Comprehensive genetic testing for hereditary hearing loss using massively parallel sequencing.  Proc Natl Acad Sci U S A.  2010 December 7. 107(49):21104-9.

Winder A, Wohlford-Lenane C, Scheetz T, Nardy B, Manzel L, Look D, McCray P.  Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia.  Respir Res.  2009 October 16. 10:96.

Fischer A, Goss K, Scheetz T, Wohlford-Lenane C, Snyder J, McCray P.  Differential gene expression in human conducting airway surface epithelia and submucosal glands.  Am J Respir Cell Mol Biol.  2009 February. 40(2):189-99.

Loktev A, Zhang Q, Beck J, Searby C, Scheetz T, Bazan J, Slusarski D, Sheffield V, Jackson P, Nachury M.  A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.  Dev Cell.  2008 December. 15(6):854-65.

Kalari K, Casavant T, Scheetz T.  A knowledge-based approach to predict intragenic deletions or duplications.  Bioinformatics.  2008 September 15. 24(18):1975-9.

Ben-Shahar Y, Nannapaneni K, Casavant T, Scheetz T, Welsh M.  Eukaryotic operon-like transcription of functionally related genes in Drosophila.  Proc Natl Acad Sci U S A.  2007 January 2. 104(1):222-7.

Kalari K, Casavant M, Bair T, Keen H, Comeron J, Casavant T, Scheetz T.  First exons and introns--a survey of GC content and gene structure in the human genome.  In Silico Biol.  2006. 6(3):237-42.

Gerhard D, Wagner L, Feingold E, Shenmen C, Grouse L, Schuler G, Klein S, Old S, Rasooly R, Good P, Guyer M, Peck A, Derge J, Lipman D, Collins F, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut S, Schaefer C, Buetow K, Bonner T, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat N, Hopkins R, Hsie F, Driscoll T, Soares M, Casavant T, Scheetz T, Brown-stein M, Usdin T, Toshiyuki S, Carninci P, Piao Y, Dudekula D, Ko M, Kawakami K, Suzuki Y, Sugano S, Gruber C, Smith M, Simmons B, Moore T, Waterman R, Johnson S, Ruan Y, Wei C, Mathavan S, Gunaratne P, Wu J, Garcia A, Hulyk S, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny D, McPherson J, Gibbs R, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young A, Wetherby K, Granite S, Kwong P, Brinkley C, Pearson R, Bouffard G, Blakesly R, Green E, Dickson M, Rodriguez A, Grimwood J, Schmutz J, Myers R, Butterfield Y, Griffith M, Griffith O, Krzywinski M, Liao N, Morin R, Morrin R, Palmquist D, Petrescu A, Skalska U, Smailus D, Stott J, Schnerch A, Schein J, Jones S, Holt R, Baross A, Marra M, Clifton S, Makowski K, Bosak S, Malek J.  The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  Genome Res.  2004 October. 14(10B):2121-7.

Scheetz T, Casavant T.  Informatics for Efficient EST-Based Gene Discovery in Normalized and Subtracted cDNA Libraries.  World Scientific Press.  2004 May. 

Hackett J, Yoon H, Soares M, Bonaldo M, Casavant T, Scheetz T, Nosenko T, Bhattacharya D.  Migration of the plastid genome to the nucleus in a peridinin dinoflagellate.  Curr Biol.  2004 February 3. 14(3):213-8.

Strausberg R, Feingold E, Grouse L, Derge J, Klausner R, Collins F, Wagner L, Shenmen C, Schuler G, Altschul S, Zeeberg B, Buetow K, Schaefer C, Bhat N, Hopkins R, Jordan H, Moore T, Max S, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer A, Rubin G, Hong L, Stapleton M, Soares M, Bonaldo M, Casavant T, Scheetz T, Brownstein M, Usdin T, Toshiyuki S, Carninci P, Prange C, Raha S, Loquellano N, Peters G, Abramson R, Mullahy S, Bosak S, McEwan P, McKernan K, Malek J, Gunaratne P, Richards S, Worley K, Hale S, Garcia A, Gay L, Hulyk S, Villalon D, Muzny D, Sodergren E, Lu X, Gibbs R, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young A, Shevchenko Y, Bouffard G, Blakesley R, Touchman J, Green E, Dickson M, Rodriguez A, Grimwood J, Schmutz J, Myers R, Butterfield Y, Krzywinski M, Skalska U, Smailus D, Schnerch A, Schein J, Jones S, Marra M.  Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.  Proc Natl Acad Sci U S A.  2002 December 24. 99(26):16899-903.

Kwitek A, Tonellato P, Chen D, Gullings-Handley J, Cheng Y, Twigger S, Scheetz T, Casavant T, Stoll M, Nobrega M, Shiozawa M, Soares M, Sheffield V, Jacob H.  Automated construction of high-density comparative maps between rat, human, and mouse.  Genome Res.  2001 November. 11(11):1935-43.

Scheetz T, Raymond M, Nishimura D, McClain A, Roberts C, Birkett C, Gardiner J, Zhang J, Butters N, Sun C, Kwitek-Black A, Jacob H, Casavant T, Soares M, Sheffield V.  Generation of a high-density rat EST map.  Genome Res.  2001 March. 11(3):497-502.

Dimopoulos G, Casavant T, Chang S, Scheetz T, Roberts C, Donohue M, Schultz J, Benes V, Bork P, Ansorge W, Soares M, Kafatos F.  Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines.  Proc Natl Acad Sci U S A.  2000 June 6. 97(12):6619-24.

Scheetz T, Braun T, Casavant T, Gannon J, Andersland M, Dietz R.  Effectiveness of software trace recovery techniques for current parallel architectures.  Proceedings of the International Conference on High Performance Computing.  1995. 

Date Last Modified: 06/07/2014 - 21:56:23