Ophthalmology And Visual Sciences

Markus H. Kuehn, PhD

Portrait

Associate Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 4120F  MERF
Iowa City, IA 52242
Primary Office Phone: 319-335-9565

Email: markus-kuehn@uiowa.edu

Education

MS, Botany, Goethe University (Frankfurt)
PhD, Cell and Molecular Biology, St. Louis University

Post Doctoral, Ophthalmology, The University of Iowa

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Neuroscience

Research Summary

My laboratory studies the cellular and genetic mechanisms that are involved in glaucoma. Toward this end we have developed a variety of techniques that can be used to evaluate ocular phenotypes in animal models of the disease and have developed extensive expertise in the analysis of genetic data. While the majority of our work is carried out either human samples or rodent models we have developed substantial experience working with both cat and dog models of glaucoma.

Center, Program and Institute Affiliations

Stephen A. Wynn Institute for Vision Research

All Publications

Mullins R, Kuehn M, Radu R, Enriquez G, East J, Schindler E, Travis G, Stone E.  Autosomal recessive retinitis pigmentosa due to ABCA4 mutations: clinical, pathologic, and molecular characterization..  Investigative ophthalmology & visual science.  2012 April. 53(4):1883-94.
[PubMed]

Mullins R, Kuehn M, Radu R, Enriquez G, East J, Schindler E, Travis G, Stone E.  Autosomal Recessive Retinitis Pigmentosa Due to Abca4 Mutations: Clinical, Pathologic and Molecular Characterization.  Invest Ophthalmol Vis Sci.  2012. 53(4):1883-94.

Kuehn M, Ahram D, Grozdanic S, Kecova H.  Investigation of Gene-Expression Patterns in Familial Angle-Closure Glaucoma in the Basset Hound.  Invest Ophthalmol Vis Sci.  2012. 51:4509.

Kuehn M.  Involvement of the Immune and Complement Systems in Glaucoma.  International Congress of Eye Research .  2012. 

Ding Q, Cook A, Dumitrescu A, Kuehn M.  Lack of Immunoglobulins Does Not Prevent C1q Binding to RGC and Does not Alter the Progression of Experimental Glaucoma.  Invest Ophthalmol Vis Sci.  2012. 53(10):6370-7.
[PubMed]

Mullins R, Dewald A, Streb L, Wang K, Kuehn M, Stone E.  Elevated membrane attack complex in human choroid with high risk complement factor H genotypes..  Experimental eye research.  2011 October. 93(4):565-7.
[PubMed]

Sigle K, Camaño-Garcia G, Carriquiry A, Betts D, Kuehn M, McLellan G.  The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma.  Vet Ophthalmol.  2011 September. 14 Suppl 1:48-53.
[Link]

Rutz-Mendicino M, Snella E, Jens J, Gandolfi B, Carlson S, Kuehn M, McLellan G, Ellinwood N.  Removal of potentially confounding phenotypes from a Siamese-derived feline glaucoma breeding colony.  Comp Med.  2011 June. 61(3):251-7.
[Link]

Harper M, Grozdanic S, Blits B, Kuehn M, Zamzow D, Buss J, Kardon R, Sakaguchi D.  Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes.  Invest Ophthalmol Vis Sci.  2011 June. 52(7):4506-15.
[Link]

Lavik E, Kuehn M, Kwon Y.  Novel drug delivery systems for glaucoma.  Eye (Lond).  2011 May. 25(5):578-86.
[Link]

Zode G, Nishimura D, Ding Q, Searby C, Mohan K, Grozdanic S, Stone E, Sheffield V, Kuehn M.  A Chemical Chaperone Rescues Glaucoma by Reducing ER Stress in a Novel Murine Model of Primary Open Angle Glaucoma.  Invest Ophthalmol Vis Sci.  2011. 50:5917.

Yang X, Luo C, Cai J, Powell D, Kuehn M, Tezel G.  A20 Zinc Finger Protein in the Regulation of TNF-α Signaling in Human Glaucoma.  Invest Ophthalmol Vis Sci.  2011. 50:3107.

Roos B, Kuehn M, Wang K, Stone E, Kwon Y, Alward W, Fingert J.  Association Study Of Cav1 And Cav2 In Primary Open Angle Glaucoma Patients From Iowa .  Invest Ophthalmol Vis Sci.  2011. 50(suppl).

Roos B, Kuehn M, Wang K, Stone E, Kwon Y, Alward W, Fingert J.  Association Study of Cav1 and Cav2 in Primary Open Angle Glaucoma Patients from Iowa.  Invest Ophthalmol Vis Sci.  2011. 50:2411.
[Link]

Kuehn M, Wang K, Roos B, Stone E, Kwon Y, Alward W, Mullins R, Fingert J.  Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort..  Molecular vision.  2011. 17:430-5.
[PubMed]

Kuehn M.  Gene Expression in the Human Glaucomatous Optic Nerve Head.  Optic Nerve Degeneration .  2011. 

Ding Q, Dumitrescu A, Cook A, Bushek S, Kuehn M.  Lack of Immunoglobulins Does not Prevent C1q Binding to RGC and Does not Alter the Progression of Experimental Glaucoma.  Invest Ophthalmol Vis Sci.  2011. 50:4603.

Yang X, Luo C, Cai J, Powell D, Yu D, Kuehn M, Tezel G.  Neurodegenerative and Inflammatory Pathway Components Linked to TNF-α/TNFR1 Signaling in the Glaucomatous Human Retina.  Invest Ophthalmol Vis Sci.  2011. 52(11):8442-54.
[PubMed]

Kuehn M, Zode G, Sheffield V.  Reduction of ER Stress Alleviates Glaucome Symptoms in a Mouse Model of Myocilin Glaucoma.  World Glaucoma Congress.  2011. 

Zode G, Kuehn M, Nishimura D, Searby C, Mohan K, Grozdanic S, Bugge K, Anderson M, Clark A, Stone E, Sheffield V.  Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.  The Journal of clinical investigation.  2011. 121(9):3542-53.
[PubMed]

Kuehn M, McLellan G, Pfleging A, Snella E, Ellinwood N.  Spontaneous Mutations In LTBP2 Are Associated With Congenital Glaucoma In Cats.  Invest Ophthalmol Vis Sci.  2011. 50(suppl).

Dumitrescu A, Atkins K, Shoffstall A, Kuehn M, Kwon Y, Lavik L.  Sustained Delivery of Timolol Reduces IOP, in Rabbits for Over 10 weeks.  Invest Ophthalmol Vis Sci.  2011. 50(Suppl).

Trantow C, Cuffy T, Fingert J, Kuehn M, Anderson M.  Microarray analysis of iris gene expression in mice with mutations influencing pigmentation..  Investigative ophthalmology & visual science.  2011 January. 52(1):237-48.
[PubMed]

Luo C, Yang X, Kain A, Powell D, Kuehn M, Tezel G.  Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling.  Invest Ophthalmol Vis Sci.  2010 November. 51(11):5697-707.
[Link]

Tezel G, Yang X, Luo C, Kain A, Powell D, Kuehn M, Kaplan H.  Oxidative stress and the regulation of complement activation in human glaucoma.  Invest Ophthalmol Vis Sci.  2010 October. 51(10):5071-82.
[Link]

Grozdanic S, Lazic T, Kuehn M, Harper M, Kardon R, Kwon Y, Lavik E, Sakaguchi D.  Exogenous modulation of intrinsic optic nerve neuroprotective activity.  Graefes Arch Clin Exp Ophthalmol.  2010 August. 248(8):1105-16.
[Link]

Tezel G, Yang X, Luo C, Cai J, Kain A, Powell D, Kuehn M, Pierce W.  Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation.  Invest Ophthalmol Vis Sci.  2010 February. 51(2):907-19.
[Link]

Zode G, Nishimura D, Searby C, Stone E, Dumitrescu A, Sheffield V, Kuehn M.  Activation of Unfolded Protein Response in the Trabecular Meshwork of Transgenic Mice Expressing Tyr437His Mutant of Human Myocilin.  Invest Ophthalmol Vis Sci.  2010. 51(suppl).

Grozdanic S, Kecova H, Harper M, Kuehn M, Lavik E, Kardon R.  BDNF Mediated Functional and Structural Optic Nerve Protection in Canine Hypertensive Eyes.  Invest Ophthalmol Vis Sci .  2010. 51(Suppl).

Ellinwood N, Deckman K, Zhao Z, Rutz-Mendicino M, Jens J, David V, Kuehn M, O'Brien S, Menotti-Raymond M, McLellan G.  Candidate Gene Analysis of a Feline Model of Primary Congenital Glaucoma Implicates LTBP2 as the Causative Locus.  Invest Ophthalmol Vis Sci.  2010. 51(suppl).

Fernandez de Castro J, Mullins R, Hernandez J, Kuehn M.  Elevated Deposition of Lipofuscin in Glaucomatous Optic Nerves.  Invest Ophthalmol Vis Sci.  2010. 51(suppl).

Jiang B, Harper M, Kecova H, Adamus G, Kardon R, Grozdanic S, Kuehn M.  Elevated Expression of Immunomodulatory Genes in Advanced Canine Glaucoma.  Mol. Vis.  2010. 16:2092-2108.

Kuehn M.  Gene Expression Analyses of the Human Optic Nerve Head in Glaucoma.  Int. Congress Eye Res.  2010. 

Dumitrescu A, Bertram J, Olson L, Jens J, Ellinwood N, Kwon Y, Lavik E, Kuehn M.  In-vivo Characterization of Sustained Release Timolol Microspheres.  Invest Ophthalmol Vis Sci.  2010. 51(suppl).

Jiang B, Harper M, Kecova H, Adamus G, Kardon R, Grozdanic S, Kuehn M.  Neuroinflammation in advanced canine glaucoma.  Mol Vis.  2010. 16:2092-108.
[Link]

Jiang B, Harper M, Kecova H, Adamus G, Kardon R, Grozdanic S, Kuehn M.  Neuroinflammation in advanced canine glaucoma..  Molecular vision.  2010. 16:2092-108.
[PubMed]

Tezel G, Yang X, Luo C, Cai J, Pierce W, Kuehn M.  Proteomic Analysis of Human Retina: Ocular Hypertension versus Glaucoma.  Invest Ophthalmol Vis Sci.  2010. 51(suppl).

Harper M, Eggers L, Kuehn M, Sakaguchi D, Kardon R, Grozdanic S.  Quantification and Correlation of Neurotrophic Factor Expression With Medical Histories in Healthy and Glaucomatous Tissue.  Invest Ophthalmology Vis Sci.  2010. 51(suppl).

Yang X, Luo C, Powell D, Kuehn M, Tezel G.  Regulation of Complement Factor H in Human Glaucoma and Oxidative Stress.  Invest Ophthalmol Vis Sci.  2010. 51(suppl).

Grozdanic S, Kecova H, Harper M, Nilaweera W, Kuehn M, Kardon R.  Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma.  Invest Ophthalmol Vis Sci.  2010 January. 51(1):255-63.
[Link]

Lively G, Jiang B, Hedberg-Buenz A, Chang B, Petersen G, Wang K, Kuehn M, Anderson M.  Genetic dependence of central corneal thickness among inbred strains of mice..  Investigative ophthalmology & visual science.  2010 January. 51(1):160-71.
[PubMed]

Kwon Y, Fingert J, Kuehn M, Alward W.  Primary open-angle glaucoma..  The New England journal of medicine.  2009 March. 360(11):1113-24.
[PubMed]

Kuehn M, Ryan R, Dumitrescu A.  Accumulation of Complement Components in the Glaucomatous Human Optic Nerve.  Invest Ophthalmol Vis Sci.  2009. 50(Suppl).

Grozdanic S, Kecova H, Harper M, Nilaweera W, Kuehn M, Kardon R.  Cholinergic Drug Induced Reversal of Early Functional Deficits in Glaucoma.  Invest Ophthalmol Vis Sci.  2009. 50(Suppl).

Harper M, Sakaguchi D, Kuehn M, Kwon Y, Kardon R, Bemelmans A, et al .  Comparison of Visual Preservation After Transplantation of BDNF or GDNF Secreting Mesenchymal Stem Cells in Glaucomatous Rat Eyes.  Invest Ophthalmol Vis Sci.  2009. 50(Suppl).

Lively G, Hedberg-Buenz A, Wang A, Kuehn M, Anderson M.  Identification of a Locus Contributing to Murine Central Corneal Thickness.  Invest Ophthalmol Vis Sci.  2009. 50(suppl).

Dumitrescu A, Stefl M, Kuehn M.  Increased Ganglion Cell Dendrite Branching is an Early Step in Experimental Glaucoma.  Invest Ophthalmol Vis Sci.  2009. 50(suppl).

Kwon Y, Fingert J, Kuehn M, Alward W.  Mechanism of Disease: Primary Open Angle Glaucoma.  N. Engl. J. Med.  2009. 360(11):1113-1124.

Kwon Y, Fingert J, Kuehn M, Wallace L, Alward W.  Mechanisms of Disease: Primary Open-Angle Glaucoma.  N. Engl. J. Med.  2009. 360(11):1113-1124.

Mullins R, Schindler E, Enriquez G, Faidley E, Kuehn M, Stone E.  Morphology and Gene Expression Analysis of ABCA4-associated Retinitis Pigmentosa.  Invest Ophthalmol Vis Sci.  2009. 50(Suppl).

Ellinwood N, Jens J, Rutz M, Faylon M, Snella E, Kuehn M, et al .  Preliminary Characterization of the Genetics and Inheritance of Primary Congenital Glaucoma in a Spontaneous Feline Model .  Invest Ophthalmol Vis Sci.  2009. 50(Suppl).

Yang X, Luo C, Powell D, Klein J, Kuehn M, Tezel G.  Proteomic Analysis of TNF-α Signaling in Human Glaucoma.  Invest Ophthalmol Vis Sci.  2009. 50(suppl).

Tezel G, Yang X, Luo C, Powell D, Klein J, Kaplan H, Kuehn M.  Proteomics Supports Different Pathways of Complement Activity in Human Glaucoma.  Invest Ophthalmol Vis Sci.  2009. 50(Suppl).

Kuehn M, McLellan G, Pfleging A, Snella E, Ellinwood N.  Spontaneous mutations in LTBP2 are Associated with Congenital Glaucoma in Cats.  Invest Ophtahlmol Vis Sci.  2009. 50(suppl):2424.

Dumitrescu A, Atkins K, Shoffstall A, Kuehn M, Kwon Y, Lavik L.  Sustained Delivery of Timolol Reduces IOP, in Rabbits for Over 10 Weeks.  Invest Ophtalmol Vis Sci.  2009. 50:3100.

Tezel G.  The role of glia, mitochondria, and the immune system in glaucoma.  Invest Ophthalmol Vis Sci.  2009. 50(3):1001-1012.

Ostojić J, Grozdanić S, Syed N, Hargrove M, Trent J, Kuehn M, Kwon Y, Kardon R, Sakaguchi D.  Patterns of distribution of oxygen-binding globins, neuroglobin and cytoglobin in human retina.  Arch Ophthalmol.  2008 November. 126(11):1530-6.
[Link]

Ostojic J, Grozdanic S, Syed N, Hargrove M, Trent J, Kuehn M, Kardon R, Kwon Y, Sakaguchi D.  Neuroglobin and cytoglobin distribution in the anterior eye segment: a comparative immunohistochemical study.  J Histochem Cytochem.  2008 September. 56(9):863-72.
[Link]

Kuehn M, Kim C, Jiang B, Dumitrescu A, Kwon Y.  Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion.  Exp Eye Res.  2008 August. 87(2):89-95.
[Link]

Mullins R, Enriquez S, Faidley E, Schindler E, Kuehn M, Stone E.  Anatomic and molecular changes in retinitis pigmentosa.  Program # 2222, American Society of Cell Biology Annual Meeting.  2008. 

Grozdanic S, Harper M, Kecova H, Nilaweera W, Boll A, Kuehn M, Sakaguchi D, Kardon R.  Antibody Mediated Retinopathy - New Mechanisms and Treatment Strategies.  Invest Ophthalmol Vis Sci.  2008. 49(Suppl).

Skeie J, Kuehn M, Fishbaugh J, Mullins R.  Choroidal Endothelial Cell Responses to Elastin Fragments.  Invest Ophthalmol Vis Sci.  2008. 49(Suppl).

Harper M, Eggers L, Holland E, Boll A, Sterner N, Kuehn M, Sakaguchi D, Kardon R, Grozdanic S.  Quantification of Neurotrophic Factor Expression in Human and Canine Glaucomatous and Normal Retinas.  Invest Ophthalmol Vis Sci.  2008. 49(Suppl).

Lavik E, Bertram J, Saluja S, McKain J, Jiang B, Kuehn M, Kwon Y.  Sustained Delivery of Timolol Maleate From Poly(Lactic-Co-Glycolic Acid)/Poly(Lactic Acid) Microspheres.  Invest Ophthalmol Vis Sci.  2008. 49(Suppl).

Kuehn M.  The Role of Complement in Glaucoma.  International Congress of Eye Research.  2008. 

Kim C, Kuehn M, Anderson M, Kwon Y.  Intraocular pressure measurement in mice: a comparison between Goldmann and rebound tonometry..  Eye (London, England).  2007 September. 21(9):1202-9.
[PubMed]

Mullins R, Kuehn M, Faidley E, Syed N, Stone E.  Differential macular and peripheral expression of bestrophin in human eyes and its implication for best disease..  Investigative ophthalmology & visual science.  2007 July. 48(7):3372-80.
[PubMed]

Kuehn M, Kim C, Jiang B, Kwon Y.  Complement Activation Accelerates Retinal Ganglion Cell Loss in Ocular Ischemia.  Invest Ophthalmol Vis Sci.  2007. 48(Suppl).

Grozdanic S, Sakaguchi D, Kuehn M, Lavik E, Kwon Y, Kardon R.  Exogenous modulation of intrinsic optic nerve neuroprotective activity in rodent eyes exposed to elevated intraocular pressure.  Invest Ophthalmol Vis Sci.  2007. 48(Suppl).

Jiang B, Grozdanic S, Kardon R, Kuehn M.  Gene Expression in the Canine Glaucomatous Retina.  Invest Ophthalmol Vis Sci.  2007. 48(Suppl).

Mullins R, Kuehn M, Faidley E, Olvera M, Syed N, Stone E.  Macular and Peripheral Expression of Bestrophin in Human Eyes: Potential Significance to the Pathophysiology of Best Disease.  Invest Ophthalmol Vis Sci.  2007. 48(Suppl).

Sakaguchi D, Harper M, Grozdanic S, Blits B, Kuehn M, Kim C, Kwon Y, Reger R, Prockop D, Bunge M, Kardon R.  Preservation of Visual Function After Intraocular Transplantation of BDNF Secreting Mesenchymal Stem Cells in Chronic Hypertensive Rat Eyes.  Invest Ophthalmol Vis Sci.  2007. 

Kuehn M, Kim C, Ostojic J, Bellin M, Alward W, Stone E, Sakaguchi D, Grozdanic S, Kwon Y.  Retinal synthesis and deposition of complement components induced by ocular hypertension..  Experimental eye research.  2006 September. 83(3):620-8.
[PubMed]

Ostojić J, Sakaguchi D, de Lathouder Y, Hargrove M, Trent J, Kwon Y, Kardon R, Kuehn M, Betts D, Grozdanić S.  Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons.  Invest Ophthalmol Vis Sci.  2006 March. 47(3):1016-23.
[Link]

McLellan G, Kuehn M, Ellinwood N, Kim C, Jens J, Sigle K, Petersen C.  A Feline Model of Primary Congenital Glaucoma - Histopathological And Genetic Characterization.  Invest Ophthalmol Vis Sci.  2006. 47(Suppl).

Kuehn M, Kim C, Ostojic J, Bellin M, Sakaguchi D, Grozdanic S, Kwon Y.  Complement Activation in Human and Experimental Glaucoma.  Invest Invest Ophthalmol Vis Sci .  2006. 47(Suppl).

Kim C, Kuehn M, Clark A, Kwon Y.  Gene expression profile of the adult human retinal ganglion cell layer..  Molecular vision.  2006. 12:1640-8.
[PubMed]

Kim C, Kuehn M, Clark A, Kwon Y.  Laser capture microdissection and microarray analysis of the human retinal ganglion cell layer.  Invest Ophthalmol Vis Sci.  2006. 47(Suppl).

Mullins R, Skeie J, Malone E, Kuehn M.  Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina..  Molecular vision.  2006. 12:224-35.
[PubMed]

Ostojic J, Syed N, Hargrove M, Kuehn M, Kardon R, Kwon Y, Grozdanic S, Sakaguchi D.  Neuroglobin and Cytoglobin Distribution in the Anterior Segment: A Comparative Study of the Human and Dog Eye.  Invest Ophthalmol Vis Sci.  2006. 47(Suppl).

Kim C, Kuehn M, Grozdanic S, Ostojic J, Bellin M, Kwon Y.  Comparative analysis of optic nerve head gene expression changes in human glaucoma and in rodent models of ocular hypertension.  Invest Ophthalmol Vis Sci .  2005. 46(Suppl).

Kuehn M, Kim C, Kwon Y.  Identification of Steroid-Responsive Genes in Organ Cultured Human Eyes.  Invest Ophthalmol Vis Sci.  2005. 46(Suppl).

Mullins R, Malone E, Olvera M, Kuehn M.  Macular-Peripheral Variability of ICAM-1 in Retina and Choroid.  Invest Ophthalmol Vis Sci.  2005. 46(Suppl).

Ostojic J, da Lathouder Y, Trent III J, Hargrove M, Betts D, Kwon Y, Kardon R, Kuehn M, Sakaguchi D, Grozdanic S.  Patterns of Expression of Neuroglobin and Cytoglobin in the Healthy and Glaucomatous Dog Retina.  Invest Ophthalmol Vis Sci .  2005. 46(Suppl).

Kuehn M, Fingert J, Kwon Y.  Retinal ganglion cell death in glaucoma: Mechanisms and neuroprotective strategies.  2005. 18:383-395.

Kuehn M, Fingert J, Kwon Y.  Retinal Ganglion Cell Death in Glaucoma: Mechanisms and Neuroprotective Strategies.  2005. 

Stone E, Braun T, Russell S, Kuehn M, Lotery A, Moore P, Eastman C, Casavant T, Sheffield V.  Missense variations in the fibulin 5 gene and age-related macular degeneration..  The New England journal of medicine.  2004 July. 351(4):346-53.
[PubMed]

Kuehn M, Sheffield V, Stone E, Alward W, Kwon Y.  Characterization of gene expression patterns in the developing retina of normal and NR2E3 mutant mice.  Invest. Ophthalmol. Vis. Sci.  2004. 45(Suppl).

Grozdanic S, Ostojic J, Syed N, Hargrove M, Trent J, Betts D, Kuehn M, Kwon Y, Kardon R, Sakaguchi D.  Neuroglobin and Histoglobin (cytoglobin) – New hexacoordinate globins in the human eye.  Invest Ophthalmol Vis Sci.  2004. 45(Suppl).

Sakaguchi D, Orasky J, Grozdanic S, Hildreth S, Lazic T, Lavik E, Betts D, Kwon Y, Kardon R, Kuehn M.  Sustained Delivery Of Neurotrophic Growth Factors From Biodegradable Microspheres After Acute Elevation Of Intraocular Pressure In Rat Eyes.  Society for Neuroscience.  2004. 

Mullins R, Kuehn M, Aptsiauri N, Hageman G.  Distribution of Terminal Complement Complexes at the RPE-Choriocapillaris Interface in Age-Related Macular Degeneration.  Invest Ophthalmol Vis Sci.  2003. 44(Suppl):e507.

Stone E, Russell S, Braun T, Kuehn M, Lotery A, Moore P, Casavant T, Sheffield V.  Missense Variations in the Fibulin 5 Gene are Associated with Age Related Macular Degeneration.  The Macula Society.  2003. 

Hageman G, Chong N, Keonin J, Amin S, Klaver C, Frennesson C, Russell S, Luthert P, Mullins R, Kuehn M.  Topographical Differences in the Structure and Composition of Bruch’s Membrane May Explain the Predilection of the Macula for Degeneration in Individuals with Age-Related Macular Degeneration.  Invest. Ophthalmol.Vis. Sci.  2002. 43(Suppl):S1988.

Kuehn M, Stone E, Hageman G.  Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders..  Investigative ophthalmology & visual science.  2001 December. 42(13):3123-9.
[PubMed]

Alagramam K, Yuan H, Kuehn M, Murcia C, Wayne S, Srisailpathy C, Lowry R, Knaus R, Van Laer L, Bernier F, Schwartz S, Lee C, Morton C, Mullins R, Ramesh A, Van Camp G, Hageman G, Woychik R, Smith R, Hagemen G.  Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F..  Human molecular genetics.  2001 August. 10(16):1709-18.
[PubMed]

Ruiz A, Kuehn M, Stone E, Hageman G, Bok D.  Characterization of the lecithin retinol acyltransferase (LRAT) gene structure and evaluation of it’s involvement in ocular disease.  Invest. Ophthalmol. Vis. Sci.  2001. 1:31-37.

Kuehn M, Stone E, Hageman G.  Organization of the Human IMPG2 Gene and Its Evaluation as a Candidate Gene in Age-Related Macular Degeneration and Other Retinal Degenerative Disorders.  Invest. Ophthalmol Vis. Sci.  2001. Suppl 42:S3123.

Ruiz A, Kuehn M, Andorf J, Stone E, Hageman G, Bok D.  Genomic organization and mutation analysis of the gene encoding lecithin retinol acyltransferase in human retinal pigment epithelium..  Investigative ophthalmology & visual science.  2001 January. 42(1):31-7.
[PubMed]

Kuehn M, Wietecki D, Hageman G.  Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150..  Molecular vision.  2000 August. 6:148-56.
[PubMed]

Kuehn M, Hageman G.  IPM 150 and IPM 200 are members of a novel family of proteoglycans.  Invest Ophthalmol Vis Sci .  2000. 41(Suppl):S594.

Gorin M, Breitner J, De Jong P, Hageman G, Klaver C, Kuehn M, Seddon J.  The genetics of age-related macular degeneration..  Molecular vision.  1999 November. 5:29.
[PubMed]

Kuehn M, Hageman G.  Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan..  Matrix biology : journal of the International Society for Matrix Biology.  1999 October. 18(5):509-18.
[PubMed]

Kuehn M, Hageman G.  Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans..  Molecular cell biology research communications : MCBRC.  1999 August. 2(2):103-10.
[PubMed]

Hageman G, Kuehn M.  Biology of the retina-IPM-RPE interface.  Oxford University Press, New York.  1998. 

Hageman G, Mullins R, Kuehn M, Stone E.  Characterization of extracellular deposits associated with AMD.  VII International Symposium on Retinal Degeneration.  1998. 

Franklin A, Kuehn M, Warner R, Thompsen J, Russell S, Rickman C, Hageman G.  Evaluation of differentially-expressed RPE gene transcripts as candidates for age-related macular degeneration.  Invest Ophthalmol Vis Sci.  1997. 38(Suppl):1640.

Felbor U, Gehrig A, Koehler M, Schmid M, Kelsell R, Hunt D, Kuehn M, Hageman G, Maumenee-Husseis I, Weber B.  Mapping, genomic organization and mutational analyses of a novel interphotoreceptor matrix gene (IPM150): a candidate for 6q-linked maculopathies.  Am. J. Human Genetics.  1997. A333(Suppl):1947.

Kuehn M, Stone E, Hageman G.  Molecular Analyses of IPM 150, a Photoreceptor Cell-Specific Proteoglycan.  Invest Ophthalmol Vis Sci.  1997. 38(Suppl):2788.

Kuehn M, Hageman G.  Characterization of a cDNA-Encoding IPM-150, a Novel Human Interphotoreceptor Matrix Chondroitin 6-Sulfate Proteoglycan.  Invest Ophthalmol Vis Sci.  1995. 36(Suppl):S510-S510.

Korn S, Kuehn M, Schneider B, Lazarus H, Hageman G.  Biochemical-characterization of Glycoproteins Bound by a Hyalocyte-Specific Antibody.  Invest Ophthalmol Vis Sci.  1993. 34(Suppl):1201-1201.

Kuehn M, Mullins R, Hageman G.  Retinal Interphotoreceptor Matrix Proteoglycan Core Protein Sequences are Unique and Highly Conserved.  Invest Ophthalmol Vis Sci.  1993. 34(Suppl):1201-1201.

Kuehn M, Hageman G.  Identification of A cDNA Clone Encoding for an Interphotoreceptor Matrix Proteoglycan.  Invest Ophthalmol Vis Sci.  1992. 33(Suppl):814-814.

Hageman G, Kirchoff-Rempe M, Rotramel J, Kuehn M.  Molecular and compositional characterization of interphotoreceptor matrix proteoglycans.  Exp. Eye Res.  1992. Suppl 33:S55.

 .  Molecular Characterization of a Novel Family of Extracellular Proteoglycans and Glycoproteins.  dissertation presented to the faculty of the graduate school of Saint Louis University. 

Date Last Modified: 06/07/2014 - 21:56:23