Ophthalmology And Visual Sciences

James C. Folk, MD


Judith (Gardner) and Donald H. Beisner, M.D., Professor of Vitreoretinal Diseases and Surgery
Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 11196J  PFP
Iowa City, IA 52242
Primary Office Phone: 319-356-4338

Email: james-folk@uiowa.edu


BS, Science, Penn State University, State College, PA
MD, Medicine, Thomas Jefferson Medical College, Phildelphia, PA

Residency, Ophthalmology, Eye & Ear Hospital, Philadelphia, PA
Fellowship, Vitreoretinal, The University of Iowa Hospitals & Clinics, Ophthalmology, Vitreoretinal

Licensure and Certifications

NBME Diplomate National Board of Medical Examiners
ABO Certification American Board of Ophthalmology
ABO Maintenance of Certification American Board of Ophthalmology

Research Summary

Dr. Folk's main research involves the genetics of age-related macular degeneration and is a collaboration with scientists in the Center for Macular Degeneration. His role is to review patient records and photographs to determine that patients have AMD and their clinical outcomes. These findings are compared to genetic findings to: discover new genes in AMD; correlate genotype to phenotype; determine the responses of specific genotypes to various therapies. He is also studying patients with AMD due to mutations in the fibulin genes. Dr. Folk was the principal investigator at Iowa for the Complications of AMD Trial. He is a member of the Executive Board and on the writing committee for the two main outcome papers of this study. He is the principal investigator at Iowa of the Age-Related Eye Disease Study 2 which is a trial testing whether supplements of omega-3-polyunsaturated fatty acids and/or lutein with zeaxanthin slows the progression of the disease. He will also be the principal investigator at Iowa of the Complications of AMD Trial which will test Avastin and Lucentis as well as fixed dosing versus ?as needed? dosing of these drugs in the treatment of wet AMD. Dr. Folk is also collecting demographic information, medical history, blood for genetic studies, and serum for studies on inflammatory mediators in patients with posterior uveitis.

Center, Program and Institute Affiliations

Carver Family Center for Macular Degeneration
Stephen A. Wynn Institute for Vision Research

Selected Publications

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Chen J, Sohn E, Folk J, Mahajan V, Kay C, Boldt H, Russell S.  Decreased macular thickness in nonproliferative macular telangiectasia type 2 with oral carbonic anhydrase inhibitors.  Retina.  2014. 34(7):1400-6.

Zhang L, Sonka M, Russell S, Folk J, Abramoff M.  Quantifying disrupted outer retina-subretinal layer in SD-OCT images in choroidal neovascularization.  Invest Ophthalmol Vis Sci.  2014. 55(4):2329-35.

Bakall B, Folk J, Boldt H, Sohn E, Stone E, Russell S, Mahajan V.  Aflibercept Therapy for Exudative Age-related Macular Degeneration Resistant to Bevacizumab and Ranibizumab.  Am J Ophthalmology;  2013.  Available from: http://www.ncbi.nlm.nih.gov/pubmed/23706500

Scheetz T, Fingert J, Wang K, Kuehn M, Knudtson L, Alward W, Boldt H, Russell S, Folk J, Casavant T, Braun T, Clark A, Stone E, Sheffield V.  A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci..  PLoS One.  2013 March 11. 8(3):e58657.

Watzke R, Folk J, Lauer A.  Foveal Involvment by acquired retinoschisis: Long-Term Visual Outcomes..  Retina.  2013 March. 33(3):606-612.

Cunningham M, Tarantola R, Folk J, Sohn E, Boldt H, Graff J, Elkins K, Russell S, Mahajan V.  Proliferative vitreoretinopathy may be a risk factor in combined macular hole retinal detachment cases.  Retina.  2013 March. 33(3):579-585.

Abramoff M, Folk J, Han D, Walker J, Williams D, Russell S, Massin P, Cochener B, Gain P, Tang L, Lamard M, Moga D, Quellec G, Niemeijer M.  Automated analysis of retinal images for detection of referable diabetic retinopathy..  JAMA Ophthalmol.  2013 March 1. 131(3):351-7.

Tarantola R, Tsui J, Graff J, Russell S, Boldt H, Mahajan V, Folk J.  Intraoperative sclerotomy-related retinal breaks during 23-gauge pars plana vitrectomy.  Retina.  2013 January. 33(1):136-142.


Skeie J, Brown E, Russell S, Birkholz E, Folk J, Boldt H, Gehrs K, Stone E, Wright M, Mahajan V.  Proteomic analysis of vitreous biopsy techniques..  Retina.  2012 December. 32(10):2141-2149.

Date Last Modified: 06/07/2014 - 21:56:23