Ophthalmology And Visual Sciences

Wallace L. Alward, MD

Portrait

Frederick C. Blodi Chair in Ophthalmology
Vice-Chair, Ophthalmology
Director, Glaucoma Service
Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 11190C  PFP
Iowa City, IA 52242
Primary Office Phone: 319-356-2228

Email: wallace-alward@uiowa.edu
Web: Iowa Glaucoma Center
Web: Gonioscopy.org

Education

AB, Biology, Kenyon College
MD, Medicine, Ohio State University

Internship, General Surgery, University Hospitals of Pittsburgh
Ophthalmology, University of Louisville
Residency, Ophthalmology, University of Louisville
Fellowship, Glaucoma, Bascom Palmer Eye Institute, University of Miami

Licensure and Certifications

State of Florida Medical License (inactive)
State of Kentucky Medical License (inactive)
State of Alaska Medical License (Inactive)
ABO Certification, American Board of Ophthalmology
NBME Diplomate, National Board of Medical Examiners

Research Summary

Dr. Alward is primarily a glaucoma clinician. His areas of research interest include pigmentary glaucoma, combined glaucoma and cataract surgery, normal tension glaucoma, and gonioscopy. The major focus of his research over the last many years has been the molecular genetics of glaucoma. In collaboration with Edwin Stone and Val Sheffield, Dr. Alward was part of the team that described the first gene for primary open angle glaucoma. He was involved in the the discovery of the myocilin gene for primary open angle glaucoma, the PITX2 and FOXC1 genes for Axenfeld-Rieger syndrome and the TBK1 gene for normal tension glaucoma.

Center, Program and Institute Affiliations

Carver Family Center for Macular Degeneration
Institute for Vision Research

All Publications

Fingert J, Burden J, Wang K, Kwon Y, Alward W, Anderson M.  Circumferential Iris Transillumination Defects in Exfoliation Syndrome..  Journal of glaucoma.  2013 September. 22(7).
[PubMed]

Seo S, Solivan-Timple F, Roos B, Robin A, Stone E, Young Y, Alward W, Fingert J.  Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma.  Curr Eye Res.  2013 February. 38(2).

Hong E, Burden J, Alward W.  Intralesional ethanol for an unresectable epithelial inclusion cyst.  JAMA Ophthlamol.  2013 February. 131(2):262-3.
[PubMed]

Fingert J, Roos B, Solivan-Timpe F, Miller K, Oetting T, Wang K, Kwon Y, Scheetz T, Stone E, Alward W.  Analysis of ASB10 variants in open angle glaucoma..  Human molecular genetics.  2012 October. 21(20):4543-8.
[PubMed]

Wandling G, Rauen M, Goins K, Kitzmann A, Sutphin J, Kwon Y, Alward W, Wagoner M.  Glaucoma therapy escalation in eyes with pseudophakic corneal edema after penetrating keratoplasty and Descemet's stripping automated endothelial keratoplasty..  International ophthalmology.  2012 February. 32(1):14-Sep.
[PubMed]

Mao M, Solivan-Timpe F, Roos B, Mullins R, Oetting T, Kwon Y, Brzeskiewicz P, Stone E, Alward W, Anderson M.  Localization of SH3PXD2B in human eyes and detection of rare variants in patients with anterior segment diseases and glaucoma.  Molecular vision.  2012. 18:705-13.
[PubMed]

Tang L, Garvin M, Lee K, Alward W, Kwon Y, AbrÌÊmoff M.  Robust multiscale stereo matching from fundus images with radiometric differences..  IEEE transactions on pattern analysis and machine intelligence.  2011 November. 33(11):2245-58.
[PubMed]

Fingert J, Robin A, Stone J, Roos B, Davis L, Scheetz T, Bennett S, Wassink T, Kwon Y, Alward W.  Copy number variations on chromosome 12q14 in patients with normal tension glaucoma..  Human molecular genetics.  2011 June. 20(12):2482-94.
[PubMed]

Kuehn M, Wang K, Roos B, Stone E, Kwon Y, Alward W, Mullins R, Fingert J, Alward W.  Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort.  Mol Vis.  2011. 17:430-5.

Davis L, Meyer K, Schindler E, Beck J, Rudd D, Grundstad A, Scheetz T, Braun T, Fingert J, Alward W.  Copy number variations and primary open-angle glaucoma..  Investigative ophthalmology & visual science.  2011. 52(10):7122-33.
[PubMed]

Alward W.  A history of gonioscopy..  Optometry and vision science : official publication of the American Academy of Optometry.  2011 January. 88(1):29-35.
[PubMed]

Meyer K, Davis L, Schindler E, Beck J, Rudd D, Grundstad A, Scheetz T, Braun T, Fingert J, Alward W.  Genome-wide analysis of copy number variants in age-related macular degeneration..  Human genetics.  2011 January. 129(1):91-100.
[PubMed]

Wandling G, Parikh M, Robinson C, Pramanik S, Goins K, Sutphin J, Alward W, Greenlee E, Kwon Y, Wagoner M.  Escalation of glaucoma therapy after deep lamellar endothelial keratoplasty..  Cornea.  2010 September. 29(9):991-5.
[PubMed]

Fingert J, Alward W, Wang K, Yorio T, Clark A.  Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders..  Molecular vision.  2010. 16:596-601.
[PubMed]

AbrÌÊmoff M, Lee K, Niemeijer M, Alward W, Greenlee E, Garvin M, Sonka M, Kwon Y.  Automated segmentation of the cup and rim from spectral domain OCT of the optic nerve head..  Investigative ophthalmology & visual science.  2009 December. 50(12):5778-84.
[PubMed]

Kwon Y, Adix M, Zimmerman M, Piette S, Greenlee E, Alward W, AbrÌÊmoff M.  Variance owing to observer, repeat imaging, and fundus camera type on cup-to-disc ratio estimates by stereo planimetry..  Journal of glaucoma.  2009 April. 18(4):305-10.
[PubMed]

Trantow C, Mao M, Petersen G, Alward E, Alward W, Fingert J, Anderson M.  LYST mutation in mice recapitulates iris defects of human exfoliation syndrome..  Investigative ophthalmology & visual science.  2009 March. 50(3):1205-14.
[PubMed]

Kwon Y, Fingert J, Kuehn M, Alward W.  Primary open-angle glaucoma..  The New England journal of medicine.  2009 March. 360(11):1113-24.
[PubMed]

Alward W.  How to choose a prostaglandin analogue.  Am J Ophthalmol.  2009. 147(1):1-2.

Alward W.  How I choose a prostaglandin analogue..  American journal of ophthalmology.  2009 January. 147(1):2-Jan.
[PubMed]

Fingert J, Alward W, Kwon Y, Wang K, Streb L, Sheffield V, Stone E.  LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States..  American journal of ophthalmology.  2007 December. 144(6):974-975.
[PubMed]

Hewitt A, Poulsen J, Alward W, Bennett S, Budde W, Cooper R, Craig J, Fingert J, Foster P, Garway-Heath D.  Heritable features of the optic disc: a novel twin method for determining genetic significance..  Investigative ophthalmology & visual science.  2007 June. 48(6):2469-75.
[PubMed]

Dinn R, Zimmerman M, Shuba L, Doan A, Maley M, Greenlee E, Alward W, Kwon Y.  Concordance of diurnal intraocular pressure between fellow eyes in primary open-angle glaucoma..  Ophthalmology.  2007 May. 114(5):915-20.
[PubMed]

Shuba L, Doan A, Maley M, Zimmerman M, Dinn R, Greenlee E, Alward W, Kwon Y.  Diurnal fluctuation and concordance of intraocular pressure in glaucoma suspects and normal tension glaucoma patients..  Journal of glaucoma.  2007 May. 16(3):307-12.
[PubMed]

Fingert J, Honkanen R, Shankar S, Affatigato L, Ehlinger M, Moore M, Jampol L, Sheffield V, Stone E, Alward W.  Familial cavitary optic disk anomalies: identification of a novel genetic locus.  Am J Ophthalmol.  2007 May. 143(5).
[PubMed]

Honkanen R, Jampol L, Fingert J, Moore M, Taylor C, Stone E, Alward W.  Familial cavitary optic disk anomalies: clinical features of a large family with examples of progressive optic nerve head cupping..  American journal of ophthalmology.  2007 May. 143(5):788-794.
[PubMed]

AbrÌÊmoff M, Alward W, Greenlee E, Shuba L, Kim C, Fingert J, Kwon Y.  Automated segmentation of the optic disc from stereo color photographs using physiologically plausible features..  Investigative ophthalmology & visual science.  2007 April. 48(4):1665-73.
[PubMed]

Fingert J, Alward W, Kwon Y, Shankar S, Andorf J, Mackey D, Sheffield V, Stone E.  No association between variations in the WDR36 gene and primary open-angle glaucoma..  Archives of ophthalmology.  2007 March. 125(3):434-6.
[PubMed]

Honkanen R, Alward W, Cossari A.  Progressive iris changes in a case of Axenfeld-Rieger syndrome..  Archives of ophthalmology.  2006 December. 124(12):1793.
[PubMed]

Kuehn M, Kim C, Ostojic J, Bellin M, Alward W, Stone E, Sakaguchi D, Grozdanic S, Kwon Y.  Retinal synthesis and deposition of complement components induced by ocular hypertension..  Experimental eye research.  2006 September. 83(3):620-8.
[PubMed]

Fingert J, Kwon Y, Moore P, Johnston R, Kim K, Sheffield V, Alward W, Stone E.  The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa..  Ophthalmic genetics.  2006 June. 27(2):39-41.
[PubMed]

Maciolek N, Alward W, Murray J, Semina E, McNally M.  Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome..  BMC medical genetics.  2006. 7:59.
[PubMed]

Alward W.  Macular degeneration and glaucoma-like optic nerve head cupping.  American journal of ophthalmology.  2004 July. 138(1):135-6.
[PubMed]

Grassi M, Alward W, Verdick R, Langlow E, Kwon Y.  Atypical pigment dispersion syndrome in a child..  American journal of ophthalmology.  2004 April. 137(4):753-6.
[PubMed]

Alward W, Kwon Y, Kawase K, Craig J, Hayreh S, Johnson A, Khanna C, Yamamoto T, Mackey D, Roos B.  Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma..  American journal of ophthalmology.  2003 November. 136(5):904-10.
[PubMed]

Kwon Y, Kim Y, Pereira M, Montague P, Zimmerman M, Alward W.  Rate of optic disc cup progression in treated primary open-angle glaucoma..  Journal of glaucoma.  2003 October. 12(5):409-16.
[PubMed]

Honkanen R, Nishimura D, Swiderski R, Bennett S, Hong S, Kwon Y, Stone E, Sheffield V, Alward W.  A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene..  American journal of ophthalmology.  2003 March. 135(3):368-75.
[PubMed]

Alward W.  Biomedicine. A new angle on ocular development..  Science (New York, N.Y.).  2003 March. 299(5612):1527-8.
[PubMed]

Alward W.  A new angle on ocular development (Expanded into a on-line Enhanced Perspective).  Science.  2003. 299:1527-1528.

Alward W.  The OPA1 gene and optic neuropathy.  British Journal of Ophthalmology.  2003. 87:2-3.

Alward W.  The OPA1 gene and optic neuropathy..  The British journal of ophthalmology.  2003 January. 87(1):3-Feb.
[PubMed]

Graul T, Kwon Y, Zimmerman M, Kim C, Sheffield V, Stone E, Alward W.  A case-control comparison of the clinical characteristics of glaucoma and ocular hypertensive patients with and without the myocilin Gln368Stop mutation..  American journal of ophthalmology.  2002 December. 134(6):884-90.
[PubMed]

Pereira M, Kim C, Zimmerman M, Alward W, Hayreh S, Kwon Y.  Rate and pattern of visual field decline in primary open-angle glaucoma..  Ophthalmology.  2002 December. 109(12):2232-40.
[PubMed]

Fingert J, Stone E, Sheffield V, Alward W.  Myocilin glaucoma..  Survey of ophthalmology.  2002 November. 47(6):547-61.
[PubMed]

Alward W, Kwon Y, Khanna C, Johnson A, Hayreh S, Zimmerman M, Narkiewicz J, Andorf J, Moore P, Fingert J.  Variations in the myocilin gene in patients with open-angle glaucoma..  Archives of ophthalmology.  2002 September. 120(9):1189-97.
[PubMed]

Alward W, Kwon Y, Khanna C, Johnson A, Hayreh S, Zimmerman M, Narkiewicz J, Andorf J, Moore P, Fingert J.  Variations in the myocilin gene in patients with open-angle glaucoma..  Archives of ophthalmology.  2002 September. 120(9):1189-97.
[PubMed]

Bruno C, Alward W.  Gonioscopy in primary angle closure glaucoma..  Seminars in ophthalmology.  2002 June. 17(2):59-68.
[PubMed]

Graul T, Kim C, Alward W, Kwon Y.  Progressive axial myopia in a juvenile patient with traumatic glaucoma..  American journal of ophthalmology.  2002 May. 133(5):700-2.
[PubMed]

Borges A, Susanna R, Carani J, Betinjane A, Alward W, Stone E, Sheffield V, Nishimura D.  Genetic analysis of PITX2 and FOXC1 in Rieger Syndrome patients from Brazil..  Journal of glaucoma.  2002 February. 11(1):51-6.
[PubMed]

Kawase C, Kawase K, Taniguchi T, Sugiyama K, Yamamoto T, Kitazawa Y, Alward W, Stone E, Nishimura D, Sheffield V.  Screening for mutations of Axenfeld-Rieger syndrome caused by FOXC1 gene in Japanese patients..  Journal of glaucoma.  2001 December. 10(6):477-82.
[PubMed]

Alward W.  Additive efficacy of unoprostone isopropyl 0.12% (rescula) to latanoprost 0.005%..  American journal of ophthalmology.  2001 September. 132(3):449-51.
[PubMed]

Kwon Y, Kim C, Zimmerman M, Alward W, Hayreh S.  Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma..  American journal of ophthalmology.  2001 July. 132(1):47-56.
[PubMed]

Clark A, Kawase K, English-Wright S, Lane D, Steely H, Yamamoto T, Kitazawa Y, Kwon Y, Fingert J, Swiderski R, Mullins R, Hageman G, Alward W, Sheffield V, Stone E.  Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology.  2001 May. 15(7):1251-3.
[PubMed]

Nishimura D, Searby C, Alward W, Walton D, Craig J, Mackey D, Kawase K, Kanis A, Patil S, Stone E.  A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye..  American journal of human genetics.  2001 February. 68(2):364-72.
[PubMed]

Kwon Y, Taylor J, Hong S, Honkanen R, Zimmerman M, Alward W, Sutphin J.  Long-term results of eyes with penetrating keratoplasty and glaucoma drainage tube implant..  Ophthalmology.  2001 February. 108(2):272-8.
[PubMed]

 .  Natural History of Normal-Tension Glaucoma.  Ophthalmology.  2001. 108(2).

Fingert J, Clark A, Craig J, Alward W, Snibson G, McLaughlin M, Tuttle L, Mackey D, Sheffield V, Stone E.  Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension..  Investigative ophthalmology & visual science.  2001 January. 42(1):145-52.
[PubMed]

Jacobson N, Andrews M, Shepard A, Nishimura D, Searby C, Fingert J, Hageman G, Mullins R, Davidson B, Kwon Y, Alward W, Stone E, Sheffield V.  Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor..  Human molecular genetics.  2001 January. 10(2):117-25.
[PubMed]

Swiderski R, Ross J, Fingert J, Clark A, Alward W, Stone E, Sheffield V.  Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization..  Investigative ophthalmology & visual science.  2000 October. 41(11):3420-8.
[PubMed]

Amendt B, Semina E, Alward W.  Rieger syndrome: a clinical, molecular, and biochemical analysis..  Cellular and molecular life sciences : CMLS.  2000 October. 57(11):1652-66.
[PubMed]

Kwon Y, Hong S, Honkanen R, Alward W.  Correlation of automated visual field parameters and peripapillary nerve fiber layer thickness as measured by scanning laser polarimetry..  Journal of glaucoma.  2000 August. 9(4):281-8.
[PubMed]

Alward W.  Axenfeld-Rieger syndrome in the age of molecular genetics..  American journal of ophthalmology.  2000 July. 130(1):107-15.
[PubMed]

Alward W.  The genetics of open-angle glaucoma: the story of GLC1A and myocilin..  Eye (London, England).  2000 June. 14 ( Pt 3B):429-36.
[PubMed]

Smith R, Zabaleta A, Kume T, Savinova O, Kidson S, Martin J, Nishimura D, Alward W, Hogan B, John S.  Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development..  Human molecular genetics.  2000 April. 9(7):1021-32.
[PubMed]

Alward W.  Frequency doubling technology perimetry for the detection of glaucomatous visual field loss..  American journal of ophthalmology.  2000 March. 129(3):376-8.
[PubMed]

Alward W.  Frequency doubling technology perimetry for the detection of glaucomatous visual field loss.  American Journal of Ophthalmology.  2000. 129:376-378.

Alward W.  The Requisites in Ophthalmology.  St. Louis: Mosby, Inc.;  2000.

Haynes W, Alward W.  Combination of autologous blood injection and bleb compression sutures to treat hypotony maculopathy..  Journal of glaucoma.  1999 December. 8(6):384-7.
[PubMed]

Swiderski R, Reiter R, Nishimura D, Alward W, Kalenak J, Searby C, Stone E, Sheffield V, Lin J.  Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects..  Developmental dynamics : an official publication of the American Association of Anatomists.  1999 September. 216(1):16-27.
[PubMed]

Oh K, Alward W, Kardon R.  Myositis associated with a Baerveldt glaucoma implant..  American journal of ophthalmology.  1999 September. 128(3):375-6.
[PubMed]

Fingert J, HÌ©on E, Liebmann J, Yamamoto T, Craig J, Rait J, Kawase K, Hoh S, Buys Y, Dickinson J, Hockey R, Williams-Lyn D, Trope G, Kitazawa Y, Ritch R, Mackey D, Alward W, Sheffield V.  Analysis of myocilin mutations in 1703 glaucoma patients from five different populations..  Human molecular genetics.  1999 May. 8(5):899-905.
[PubMed]

Swiderski R, Ying L, Cassell M, Alward W, Stone E, Sheffield V.  Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain..  Brain research. Molecular brain research.  1999 May. 68(2-Jan):64-72.
[PubMed]

Haynes W, Alward W.  Control of intraocular pressure after trabeculectomy..  Survey of ophthalmology.  1999 January. 43(4):345-55.
[PubMed]

Semina E, Ferrell R, Mintz-Hittner H, Bitoun P, Alward W, Reiter R, Funkhauser C, Daack-Hirsch S, Murray J.  A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD..  Nature genetics.  1998 June. 19(2):167-70.
[PubMed]

Nishimura D, Swiderski R, Alward W, Searby C, Patil S, Bennet S, Kanis A, Gastier J, Stone E, Sheffield V.  The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25..  Nature genetics.  1998 June. 19(2):140-7.
[PubMed]

Fingert J, Ying L, Swiderski R, Nystuen A, Arbour N, Alward W, Sheffield V, Stone E.  Characterization and comparison of the human and mouse GLC1A glaucoma genes..  Genome research.  1998 April. 8(4):377-84.
[PubMed]

Fingert J, Ying L, Swiderski R, Nystuen A, Arbour N, Alward W, Sheffield V, Stone E.  Characterization and comparison of the human and mouse GLC1A glaucoma genes..  Genome research.  1998 April. 8(4):377-84.
[PubMed]

Alward W, Fingert J, Coote M.  Clinical Features Associated with Mutations in the Chromosome 1 Open-Angle Glaucoma Gene (GLC1A).  New England Journal of Medicine.  1998. 338(15):1022-1027.

Semina E, Reiter R, Leysens N.  Cloning and Characterizatio of a Novel Bicoid-Related Homeobox Transcription Factor Gene, REIG, Involved in Rieger Syndrome.  Natural Geneticfs.  1998. 14(4):498-505.

Collaborative Normal-Tension Glaucoma Study Group .  Comparison of Glaucomatous Progression between Untreated Patients with Normal-Tension Glaucoma and Patients with Therapeutically Reduced Intraocular Pressues.  American Journal of Ophthalmology.  1998. 126(4):487-497.

Alward W.  Medical Management of Glaucoma.  New England Journal.  1998. 339:1298-1307.

Collaborative Normal-Tension Glaucoma Study .  The Effectiveness of Intraocular Pressure Reduction in the Treatment of Normal-Tension Glaucoma.  American Journal of Ophthalmology.  1998. 126(4):498-505.

Alward W, Semina E, Kalenak J, HÌ©on E, Sheth B, Stone E, Murray J.  Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene..  American journal of ophthalmology.  1998 January. 125(1):98-100.
[PubMed]

McKinney J, Alward W.  Unilateral pigment dispersion and glaucoma caused by angle recession..  Archives of ophthalmology.  1997 November. 115(11):1478-9.
[PubMed]

Hayreh S, Zimmerman M, Podhajsky P, Alward W.  Nonarteritic anterior ischemic optic neuropathy: role of nocturnal arterial hypotension..  Archives of ophthalmology.  1997 July. 115(7):942-5.
[PubMed]

Carlson D, Alward W, Barad J, Zimmerman M, Carney B.  A randomized study of mitomycin augmentation in combined phacoemulsification and trabeculectomy..  Ophthalmology.  1997 April. 104(4):719-24.
[PubMed]

McKinney J, Alward W.  Unilateral pigment dispersion and glaucoma caused by angle recession.  Archives of Ophthalmology (Spanish edition).  1997. 9:106-107.

Stone E, Fingert J, Alward W, Polansky J, Nguyen T, Sunden S, Nishimura D, Clark A, Nystuen A, Nichols B.  Identification of a gene that causes primary open angle glaucoma..  Science (New York, N.Y.).  1997 January. 275(5300):668-70.
[PubMed]

Semina E, Reiter R, Leysens N, Alward W, Small K, Datson N, Siegel-Bartelt J, Bierke-Nelson D, Bitoun P, Zabel B.  Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome..  Nature genetics.  1996 December. 14(4):392-399.
[PubMed]

Sunden S, Alward W, Nichols B, Rokhlina T, Nystuen A, Stone E, Sheffield V.  Fine mapping of the autosomal dominant juvenile open angle glaucoma (GLC1A) region and evaluation of candidate genes..  Genome research.  1996 September. 6(9):862-9.
[PubMed]

Alward W, Johnson A, Nishimura D, Sheffield V, Stone E.  Molecular genetics of glaucoma: current status..  Journal of glaucoma.  1996 August. 5(4):276-84.
[PubMed]

The Fluorouracil Filtering Surgery Study Group .  Five-Year Follow-up of the Fluorouracil Filtering Surgery Study.  American Journal of Ophthalmology.  1996. 121(4):349-366.

Alward W.  Marked intraocular pressure rise following autologous blood injection into a filtering bleb.  Spanish edition of Archives of Ophthalmology.  1996. 7(88-89).

Alward W, Johnson A, Nishimura D, Sheffield V, Stone E.  Molecular genetics of glaucoma: Current status.  Journal of Glaucoma.  1996. 5:276-284.

Alward W, Ossoinig K.  Pigment dispersion secondary to cysts of the iris pigment epithelium.  Chinese edition of Archives of Ophthalmology.  1996. 5:98-99.

Haynes W, Thompson H, Johnson A, Alward W.  Comparison of the miotic effects of dapiprazole and dilute pilocarpine in patients with the pigment dispersion syndrome..  Journal of glaucoma.  1995 December. 4(6):379-85.
[PubMed]

Alward W, Ossoinig K.  Pigment dispersion secondary to cysts of the iris pigment epithelium..  Archives of ophthalmology.  1995 December. 113(12):1574-5.
[PubMed]

Alward W.  Marked intraocular pressure rise following blood injection into a filtering bleb..  Archives of ophthalmology.  1995 October. 113(10):1232-3.
[PubMed]

L H, Alward W, Tello C, Liebmann J, Ritch R.  Incomplete elimination of exercise-induced pigment dispersion by laser iridotomy in pigment dispersion syndrome..  Ophthalmic surgery and lasers.  1995 September. 26(5):484-6.
[PubMed]

HÌ©on E, Sheth B, Kalenak J, Sunden S, Streb L, Taylor C, Alward W, Sheffield V, Stone E.  Linkage of autosomal dominant iris hypoplasia to the region of the Rieger syndrome locus (4q25)..  Human molecular genetics.  1995 August. 4(8):1435-9.
[PubMed]

Haynes W, Alward W.  Rapid visual recovery and long-term intraocular pressure control after donor scleral patch grafting for trabeculectomy-induced hypotony maculopathy..  Journal of glaucoma.  1995 June. 4(3):200-1.
[PubMed]

Carlson D, Alward W, Folberg R.  Aggressive nevus of the iris with secondary glaucoma in a child..  American journal of ophthalmology.  1995 March. 119(3):367-8.
[PubMed]

HÌ©on E, Mathers W, Alward W, Weisenthal R, Sunden S, Fishbaugh J, Taylor C, Krachmer J, Sheffield V, Stone E.  Linkage of posterior polymorphous corneal dystrophy to 20q11..  Human molecular genetics.  1995 March. 4(3):485-8.
[PubMed]

Carlson D, Alward W, Folberg R.  Aggressive nevus of the iris with secondary glaucoma in a child.  American Journal of Ophthalmology.  1995. 119:367-368.

Alward W.  Linkage of posterior polymorphous corneal dystrophy to 20q11..  Human Molecular Genetics.  1995. 4:485-588.
[PubMed]

Alward W.  Marked intraocular pressure rise following autologous blood injection into a filtering bleb.  Archives of Ophthalmolgoy.  1995. 113:1232-1233.

Alward W, Ossoinig K.  Pigment dispersion secondary to cysts of the iris pigmenjt epithelium.  Archives of Ophthalmology.  1995. 113:1574-1575.

Munden P, Alward W.  Combined phacoemulsification, posterior chamber intraocular lens implantation, and trabeculectomy with mitomycin C..  American journal of ophthalmology.  1995 January. 119(1):20-9.
[PubMed]

Munden P, Alward W.  Combined phacoemulsification, posterior chamber intraocular lens implantation, and trabeculectomy with mitomycin C..  American journal of ophthalmology.  1995 January. 119(1):20-9.
[PubMed]

Campagna J, Munden P, Alward W.  Tenon's cyst formation after trabeculectomy with mitomycin C..  Ophthalmic surgery.  1995 January. 26(1):57-60.
[PubMed]

Haynes W, Alward W, McKinney J.  Low-energy argon laser suture lysis after trabeculectomy..  American journal of ophthalmology.  1994 June. 117(6):800-1.
[PubMed]

Hayreh S, Zimmerman M, Podhajsky P, Alward W.  Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders..  American journal of ophthalmology.  1994 May. 117(5):603-24.
[PubMed]

Hayreh S, Zimmerman M, Podhajsky P, Alward W.  Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders..  American journal of ophthalmology.  1994 May. 117(5):603-24.
[PubMed]

Alward W.  Color Atlas of Gonioscopy.  London: Mosby-Yearbook Europe;  1994.

Haynes W, Alward W, Thompson H.  Distortion of the pupil in patients with the pigment dispersion syndrome..  Journal of glaucoma.  1994. 3(4):329-32.
[PubMed]

Collaborative Normal-Tension Glaucoma Study Group .  Errors in the Diagnosis of Visual-Field Progression in Normal-Tension Glaucoma.  Ophthalmology.  1994. 101(9):1589-1594.

Haynes W, Alward W, McKinney J, Munden P, Verdick R.  Quantitation of iris transillumination defects in eyes of patients with pigmentary glaucoma..  Journal of glaucoma.  1994. 3(2):106-13.
[PubMed]

Alward A.  Slide Atlas of Gonioscopy.  Wolfe Slide Atlases;  1994.

Ritch R, Alward W.  Asymmetric pigmentary glaucoma caused by unilateral angle recession..  American journal of ophthalmology.  1993 December. 116(6):765-6.
[PubMed]

Joos K, Alward W, Folberg R.  Experimental endoscopic goniotomy. A potential treatment for primary infantile glaucoma..  Ophthalmology.  1993 July. 100(7):1066-70.
[PubMed]

Sheffield V, Stone E, Alward W, Drack A, Johnson A, Streb L, Nichols B.  Genetic linkage of familial open angle glaucoma to chromosome 1q21-q31..  Nature genetics.  1993 May. 4(1):47-50.
[PubMed]

Johnson A, Drack A, Kwitek A, Cannon R, Stone E, Alward W.  Clinical features and linkage analysis of a family with autosomal dominant juvenile glaucoma..  Ophthalmology.  1993 April. 100(4):524-9.
[PubMed]

Carlson D, Johnson A, Alward W.  A placebo for mitomycin C..  Ophthalmology.  1993 March. 100(3):292.
[PubMed]

The Fluorouracil Filtering Surgery Study .  3-Year Follow-up of the Fluorouracil Filtering Study Group.  American Journal of Ophthalmology.  1993. 115(1):82-92.

Farrell T, Alward W.  Fundamental of Slit Lamp Biomicroscopy.  American Academy of Ophthalmology.  1993. 

Murray J, Bennett S, Kwitek A, Small K, Schinzel A, Alward W, Weber J, Bell G, Buetow K.  Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4..  Nature genetics.  1992 September. 2(1):46-9.
[PubMed]

Haynes W, Johnson A, Alward W.  Effects of jogging exercise on patients with the pigmentary dispersion syndrome and pigmentary glaucoma..  Ophthalmology.  1992 July. 99(7):1096-103.
[PubMed]

Joos K, Brown D, Alward W.  A multilens case..  Archives of ophthalmology.  1991 October. 109(10):1343-4.
[PubMed]

Haynes W, Thompson H, Kardon R, Alward W.  Asymmetric pigmentary dispersion syndrome mimicking Horner's syndrome..  American journal of ophthalmology.  1991 October. 112(4):463-4.
[PubMed]

Alward W, Krasnow M, Keech R, Pulido J, Sutton G.  Persistent hyperplastic primary vitreous with glaucoma presenting in infancy..  Archives of ophthalmology.  1991 August. 109(8):1063-4.
[PubMed]

Lam B, Alward W, Kolder H.  Effect of cataract on automated perimetry..  Ophthalmology.  1991 July. 98(7):1066-70.
[PubMed]

Wolf M, Alward W, Folk J.  Long-term visual function in acute posterior multifocal placoid pigment epitheliopathy..  Archives of ophthalmology.  1991 June. 109(6):800-3.
[PubMed]

Joos K, Brown D, Alward W.  A multilens case.  Archives of Ophthalmology.  1991. 109(1343-1344).

Carlson D, Alward W.  A placebo for mitomycin C.  Ophthalmology.  1991. 100:1343-1344.

Haynes W, Thompson H, Kardon R, Alward W.  Asymmetric pigmentary dispersion syndrome mimicking Horner's syndrome.  American Journal of Ophthalmology.  1991. 112:463-464.

Alward W, Krasnow M, Keech R, Pulido J, Sutton G.  Persistent hyperplastic primary vitreous with glaucoma presenting in infancy.  Archives of Ophthalmology.  1991. 109:1063-1064.

Alward W, Krachmer J, Macsai M.  Arthrogryposis multiplex congenita with Peter's anomaly..  Journal of pediatric ophthalmology and strabismus.  1990 November. 27(6):329.
[PubMed]

Haynes W, Johnson A, Alward W.  Inhibition of exercise-induced pigment dispersion in a patient with the pigmentary dispersion syndrome..  American journal of ophthalmology.  1990 May. 109(5):601-2.
[PubMed]

Alward W, Munden P, Verdick R, Perell H, Thompson H.  Use of infrared videography to detect and record iris transillumination defects..  Archives of ophthalmology.  1990 May. 108(5):748-50.
[PubMed]

Bennett S, Alward W, Folberg R.  An autosomal dominant form of low-tension glaucoma..  American journal of ophthalmology.  1989 September. 108(3):238-44.
[PubMed]

Anderson D, Feuer W, Alward W, Skuta G.  Threshold equivalence between perimeters..  American journal of ophthalmology.  1989 May. 107(5):493-505.
[PubMed]

Alward W, Byrne S, Hughes J, Hodapp E.  Dislocated lens nuclei simulating choroidal melanomas.  Archieves of Ophthalmology.  1989. 107:1463-1464.

Alward W, Hodapp E, Parel J, Anderson D.  Argon laser endophotocoagulator closure of cyclodialysis clefts..  American journal of ophthalmology.  1988 December. 106(6):748-9.
[PubMed]

Relf S, Gharagozloo N, Skuta G, Alward W, Anderson D, Brubaker R.  Thymoxamine reverses phenylephrine-induced mydriasis..  American journal of ophthalmology.  1988 September. 106(3):251-5.
[PubMed]

Honkanen R, Alward W, Cossari A.  Progressive iris changes in a case of Axenfeld-Rieger Syndrome.  Journal of Infectious Disease.  1986. 153:171-172.

Alward W, Hall D, Heyward W.  The hepatitis B carrier state in the development of primary hepatocellular carcinoma.  Journal of Infectious Diseases.  1986. 153:171-172.
[PubMed]

Alward W, Bender T, Demske J, Hall D.  High prevalence of myopia among young adult Yupik Eskimos..  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.  1985 December. 20(7):241-5.
[PubMed]

Heyward W, Bender T, McMahon B, Hall D, Francis D, Lanier A, Alward W, Ahtone J, Murphy B, Maynard J.  The control of hepatitis B virus infection with vaccine in Yupik Eskimos. Demonstration of safety, immunogenicity, and efficacy under field conditions..  American journal of epidemiology.  1985 June. 121(6):914-23.
[PubMed]

McMahon B, Alward W, Hall D, Heyward W, Bender T, Francis D, Maynard J.  Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state..  The Journal of infectious diseases.  1985 April. 151(4):599-603.
[PubMed]

McMahon B, Alward W, Hall D, Heyward W, Bender T, Francis D, Maynard J.  Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state..  The Journal of infectious diseases.  1985 April. 151(4):599-603.
[PubMed]

Alward W, McMahon B, Hall D, Heyward W, Francis D, Bender T.  The long-term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma..  The Journal of infectious diseases.  1985 April. 151(4):604-9.
[PubMed]

Alward W, McMahon B, Hall D, Heyward W, Francis D, Bender T.  The long-term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma..  The Journal of infectious diseases.  1985 April. 151(4):604-9.
[PubMed]

Silimperi D, Alward W.  Microbiologic investigation of the Barrow frozen bodies.  Artic Anthropology.  1984. 21:117-121.

Alward W.  Suspect botulism - Hooper Bay Alaska (CDC).  Morbidity and Mortality Weekly Report.  1982. 

Scheetz T, Fingert J, Wang K, Kuehn M, Knudtson K, Alward W, Boldt H, Russell S, Folk J, Casavant T, Braun T, Clark A, Stone E, Sheffield V.  A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci.  PLoS One.  8(3):e58657.
[PubMed]

Date Last Modified: 11/25/2013 - 14:36:43