Obstetrics and Gynecology

Xiangbing Meng, PhD

Portrait

Research Assistant Professor of Obstetrics and Gynecology  - Reproductive Science Research

Contact Information

Primary Office: 3234 MERF
Iowa City, IA 52242
Primary Office Phone: 319-335-8212

Email: xiangbing-meng@uiowa.edu

Education

BS, Biochemistry, Beijing Normal University, China
MS, Biochemistry and Molecular Biology, Beijing Normal University, China
PhD, Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Academy of Military Medicine, Beijing, China

Post Doctoral, Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio
Post Doctoral, Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, New Mexico

Research Summary

New prognosis biomarkers and potential therapeutic targets in gynecology; Synthetic lethal studies in gynecology; Mitotic Catastrophe induction in ovarian and endometrial cancer

Selected Publications

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Meng X, Laidler L, Kosmacek E, Yang S, Xiong Z, Zhu D, Wang X, Dai D, Zhang Y, Wang X, Brachova P, Albitar L, Liu D, Ianzini F, Mackey M, Leslie K.  Induction of Mitotic Cell Death in Cancer Cells with Non-Functional p53: a New Therapeutic Strategy.  Gynecol Oncol .  2012 November 9. 128(3):461-9.
[Link]

Meng X, Zhu D, Yang S, Wang X, Xiong Z, Zhang Y, Brachova P, Leslie K.  Cytoplasmic Metadherin (MTDH) Provides Survival Advantage Under Conditions of Stress by Acting as RNA-Binding Protein.  The Journal of Biological Chemistry.  2012 February. 287(7):4485-91.
[PubMed]

Milhem M, Knutson T, Yang S, Zhu D, Wang X, Leslie K, Meng X.  Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients.  Journal of Cancer Science & Therapy.  2011 December. S5(4).
[PubMed]

Meng X, Matlawska-Wasowska K, Girodon F, Mazel T, Willman C, Atlas S, Chen I, Harvey R, Hunger S, Ness S, Winter S, Wilson B.  GSI-I (Z-LLNle-CHO) Inhibits Gamma-Secretase and the Proteosome to Trigger Cell Death in Precursor-B Acute Lymphoblastic Leukemia.  Leukemia.  2011 July. 25(7):1135-46.
[PubMed]

Yang S, Xiao X, Meng X, Leslie K.  A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors.  PloS One.  2011. 6(10):e26343.
[PubMed]

Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Thiel K, Leslie K.  Knockdown of Metadherin Sensitizes Cell Death Receptor Ligand TRAIL and HDAC Inhibitor LBH589 Co-Treatment.  PLoS One.  2011. 6(6):e20920.

Date Last Modified: 06/07/2014 - 21:56:23