Obstetrics and Gynecology

Shujie Yang, PhD

Portrait

Research Assistant Professor of Obstetrics and Gynecology  - Reproductive Science Research

Contact Information

Email: shujie-yang@uiowa.edu

Education

BA, Biochemistry, Beijing Normal University, Beijing, China
MS, Biochemistry, Beijing Normal University, Beijing, China
PhD, Biomedical Science, University of New Mexico

Post Doctoral, Obstetrics and Gynecology, University of Iowa

All Publications

Yang S, Jia Y, Liu X, Winters C, Wang X, Zhang Y, Devor E, Hovey A, Reyes H, Xiao X, Xu Y, Dai D, Meng X, Thiel K, Domann F, Leslie K.  Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer.  Oncotarget.  2014 October 30. 5(20):9783-97.
[Link]

Steinkamp M, Low-Nam S, Yang S, Lidke K, Lidke D, Wilson B.  ErbB3 is an active tyrosine kinase capable of homo- and hetero-interactions .  Mol Cell Biol.  2014 September. 34(17):965-77.

Leslie K, Thiel K, Reyes H, Yang S, Zhang Y, Carlson M, Kumar N, Dai D.  The Estrogen Receptor Joins Other Cancer Biomarkers as a Predictor of Outcome.  Obstetrics and Gynecology International.  2013 September 10. 2013 (2013)(Article ID 497541):5 pages.
[Link]

Yang S, Leslie K, Meng X.  MTDH and FOXM1, Two Master Regulators in Gynecologic Cancer.  Med J Obstet Gynecol.  2013 September 2. 1(2):1011.
[Link]

Yang S, Xiao X, Jia Y, Liu X, Zhang Y, Devor E, Meng X, Thiel K, Leslie K.  Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells.  Current Pharmaceutical Design.  2013 July. 
[PubMed]

Meng X, Laidler L, Kosmacek E, Yang S, Xiong Z, Zhu D, Wang X, Dai D, Zhang Y, Wang X, Brachova P, Albitar L, Liu D, Ianzini F, Mackey M, Leslie K.  Induction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53.  Gynecol Oncol [Epub ahead of print].  2012 November 9. 
[PubMed]

Carlson M, Thiel K, Yang S, Leslie K.  Progesterone, obesity, and the prevention of endometrial cancer.  Discov Med.  2012 September. 14(76):215-222.
[PubMed]

Leslie K, Thiel K, Goodheart M, De Geest K, Jia Y, Yang S.  Endometrial cancer .  Obstet Gynecol Clin North Am.  2012 June. 39(2):255-68.
[PubMed]

Meng X, Zhu D, Yang S, Wang X, Xiong Z, Zhang Y, Brachova P, Leslie K.  Cytoplasmic Metadherin (MTDH) Provides Survival Advantage under Conditions of Stress by Acting as RNA-binding Protein.  J Biol Chem.  2012 February 10. 287(7):4485-91.

Leslie K, Thiel K, Yang S.  Endometrial cancer: potential treatment and prevention with progestin-containing intrauterine devices.  Obstet Gynecol.  2012 February. 119(2 Pt 2):419-20.
[PubMed]

Yang S, Thiel K, De Geest K, Leslie K.  Reviving progesterone therapy in the molecular age.  Discov Med.  2011 September. 12(64):205-12.
[PubMed]

Meng X, Brachova P, Yang S, Xiong Z, Zhang Y, Thiel K, Leslie K.  Knockdown of MTDH sensitizes endometrial cancer cells to cell death induction by death receptor ligand TRAIL and HDAC inhibitor LBH589 co-treatment.  PLoS One.  2011 June. 6(6):e20920.
[PubMed]

Yang S, Thiel K, Leslie K.  Progesterone: the ultimate endometrial tumor suppressor.  Trends Endocrinol Metab.  2011 April. 22(4):145-52.

Yang S, Xiao X, Meng X, Leslie K.  A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.  PLoS One.  2011. 6(10):e26343.
[PubMed]

Hsieh M, Yang S, Raymond-Stinz M, Edwards J, Wilson B.  Spatio-temporal modeling of signaling protein recruitment to EGFR.  BMC Syst Biol 2010.  2010 May 6. 4(57).
[Link]

Hsieh M, Yang S, Raymond-Stinz M, Steinberg S, Vlachos D, Shu W, Wilson B, Edwards J.  Stochastic simulations of ErbB homo and heterodimerisation: potential impacts of receptor conformational state and spatial segregation.  IET Syst Biol 2.  2008 September. 2(5):256-72.
[PubMed]

Yang S, Raymond-Stinz M, Ying W, Zhang J, Lidke D, Steinberg S, Williams L, Oliver J, Wilson B.  Mapping ErbB receptors on breast cancer cell membranes during signal transduction.  J Cell Sci 120.  2007 August 15. 
[PubMed]

Roybal C, Yang S, Sun C, Hurtado D, Vander Jagt D, Townes T, Abcouwer S.  Homocysteine increases the expression of VEGF by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.  J Biol Chem.  2004 April 9. 279(15):14844-52.
[PubMed]

Luo S, Baumeister P, Yang S, Abcouwer S, Lee A.  Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements.  J Biol Chem .  2003 September 26. 278(39):37375-85.
[PubMed]

Xiang B, Liu P, Jiang G, Zou K, Yi F, Yang S, Wei Q.  The catalytically active domain in the A subunit of calcineurin.  Biol Chem .  2003. 384(10-11):1429-34.
[PubMed]

Yang S, Zhang L, Wei Q.  Activities and properties of calcineurin catalytic domain.  Chinese Science Bulletin.  2000 August. 45(15):1394-1399.
[Link]

Wei Q, Cui L, Yang S.  The Experimental Guide for Molecular Biology.  Chinese High Education Press;  2000.

Date Last Modified: 10/15/2014 - 11:32:35