Obstetrics and Gynecology

Donna A. Santillan, PhD

Portrait

Research Assistant Professor of Obstetrics and Gynecology  - Reproductive Science Research

Contact Information

Primary Office: 464 MRF
Iowa City, IA 52242
Primary Office Phone: 319-384-8667

Email: donna-santillan@uiowa.edu

Education

BA, History, Loyola University, Chicago, Illinois
BS, Chemistry, Biochemistry Emphasis, Loyola University, Chicago, Illinois
PhD, Biomedical Sciences-Molecular Biology, Loyola University, Maywood, Illinois

Ad hoc Graduate Program, Education, Saint Xavier University, Chicago, Illinois
Fellowship, Obstetrics & Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA

Research Summary

Novel drug delivery systems, Causes and markers of preeclampsia, Vaccination for Group B Streptococci (GBS), Non-Dietary treatment for maternal PKU, Hematopoiesis in the Neonate

All Publications

Devor E, Reyes H, Santillan D, Santillan M, Onukwugha C, Goodheart M, Leslie K.  Placenta-specific protein 1: a potential key to many oncofetal-placental OB/GYN research questions..  Obstet Gynecol Int..  2014 March 17. 2014.

Santillan D, Devor E, Leslie K, Hunter S, Santillan M.  A microRNA Expression Profile of Normal Placental Development.  Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.  2013 March. 

Ahuja M, Wang Y, Knosp B, Leslie K, Santillan M, Santillan D.  Automated Use of the Electronic Medical Record for Meaningful Clinical Data Extraction.  Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.  2013 March. 

Kowalski J, Netz R, Sinkey C, Santillan D, Fleener D, Hamilton W, Boese B, Hunter S, Leslie K, Haynes W, Santillan M.  Changes in Flow Mediated Vasodilation Predicts Development of Gestational Diabetes.  Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.  2013 March. 

Abel J, Conklin J, Hunter S, Empey R, Tyler E, Christensen A, Talcott K, Ballas Z, Santillan M, Santillan D.  Physiologic IgG Changes Throughout Pregnancy.  Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.  2013 March. 

Talcott K, Christensen A, Tyler E, Hamilton W, Boese B, Santillan D, Hunter S, Leslie K, Santillan M.  The Effect of Obesity on C-Reactive Protein Levels and Poor Pregnancy Outcomes.  Poster presentation at Society for Gynecologic Investigation 60th Annual Meeting, Orlando, FL.  2013 March. 

Santillan D, Xavier A, Santillan M, Hunter S.  Development of an Artificial Organ System to Prevent Maternal PKU Syndrome.  Poster presentation at SMFM 33rd Annual Scientific Meeting, San Francisco, CA.  2013 February 15. 

Devor E, Santillan D, Santillan M.  Preeclampsia and MicroRNAs .  Proc Obstet Gynecol, The Preeclampsia Issue.  2013 January. 3(1):2.

Santillan M, Leslie K, Hamilton W, Boese B, Conklin J, Empey R, Tyler E, Talcott K, Christensen A, Abel J, Ahuja M, Sanborn A, Sweezer E, Hunter S, Santillan D.  Collection of a Lifetime: Development of a Longitudinal Collection of Women's Healthcare Biological Samples.  POG.  2012 December. 

Snyder M, Kitzman J, Ventura A, Lewis A, Qiu R, Simmons L, Gammil H, Rubens C, Santillan D, Santillan M, Murray J, Tabor H, Bamshad M, Eichler E, Shedure J.  Methods for noninvasive prenatal determination of fetal genomes.  Oral presentation at American Society of Human Genetics, San Francisco, CA.  2012 November. 

Kyser K, Lu X, Santillan D, Santillan M, Hunter S, Cahill A, Cram P.  The association between hospital obstetrical volume and maternal postpartum complications..  American journal of obstetrics and gynecology.  2012 July. 207(1):42.e1-17.
[PubMed]

Kitzman J, Snyder M, Ventura M, Lewis A, Qiu R, Simmons L, Gammill H, Rubens C, Santillan D, Murray J, Tabor H, Bamshad M, Eichler E, Shendure J.  Noninvasive whole-genome sequencing of a human fetus..  Science translational medicine.  2012 June. 4(137):137ra76.
[PubMed]

Santillan M, Pelham C, Ketsawtsomkron P, Santillan D, Yang B, Hunter S, Sigmund C.  Chronic Indoleamine 2,3 Dioxygenase (IDO) Deficiency: A Novel Immunologic Murine Model of Preeclampsia.  Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.  2012 March. 

Santillan D, Hamilton W, Santillan M, Hunter S.  Determining the Effect of Preeclampsia on Growth and Differentiation Potential of Umbilical Cord Blood Hematopoietic Stem Cells.  Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.  2012 March. 

Santillan D, Leslie K, Sweezer E, Hamilton W, Empey R, Tyler E, Rushing J, Stegmann B, Hunter S, Santillan M.  Development of a Maternal Fetal Tissue Bank: An Investment in Maternal and Fetal Health Research.  Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.  2012 March. 

Santillan M, Santillan D, Hamilton W, Rayburn W, Hunter S, Leslie K.  The Th1 versus Th2 Cytokine Milieu in Control and Preeclamptic Pregnancies: A Second Trimester Predictor of Preeclampsia?.  Poster presentation at Society for Gynecologic Investigation 59th Annual Meeting, San Diego, CA.  2012 March. 

Santillan M, Raghuraman N, Naruko-Stewart K, Cooper K, Santillan D, Greiner A.  The Potential Role of Diuresis Criteria in Postpartum Magnesium Management of Mild and Severe Preeclampsia.  Poster presentation at SMFM 32nd Annual Scientific Meeting, Dallas, TX.  2012 February. 

Stegmann B, Santillan M, Santillan D, Smith E, Van Voorhis B, Schultz K.  Anti-Mullerian Hormone concentration levels in maternal plasma during the first, second, and third trimester of pregnancy.  Proc Obstet Gynecol.  2012. 2(3):Article 2.

Santillan M, Raghuraman N, Naruko-Stewart K, Cooper K, Santillan D, Zamba G, Greiner A.  Diuresis: Physiologic Cues to Decrease Postpartum Magnesium Administration.  American Journal of Obstetrics and Gynecology.  2012. 

Kitzman J, Snyder M, Ventura M, Lewis A, Qiu R, Simmons L, Gammill H, Rubens C, Santillan D, Murray J, Tabor H, Bamshad M, Eichler E, Shendure J.  Noninvasive whole-genome sequencing of a human fetus.  Sci Transl Med.  2012. 4:137ra76.

Santillan M, Santillan D, Fleener D, Hunter S, Yankowitz J.  Single umbilical artery: does side matter?.  Fetal diagnosis and therapy.  2012. 32(3):201-8.
[PubMed]

Empey R, Santillan D, Santillan M, Tyler E, Hunter S, Smith E, Stegmann B.  The influence of fetal sex on patterns of change in anti-Mullerian hormone during pregnancy.  Proc Obstet Gynecol.  2012. 2(3):Article 4.

Santillan D, Hamilton W, Christenson A, Talcott K, Gravatt L, Santillan M, Hunter S.  The Effects of Preeclampsia on Signaling to Hematopoietic Progenitor Cells.  POG.  2012 January. 

Stegmann B, Smith E, Hunter S, Santillan D.  Variance and Stability of Antimullerian Hormone (AMH) levels based on method of collection and time to Sample Freeze.  Accepted for poster presentation at Women's Reproductive Health Research Conference, Providence, RI.  2011 September 9. 

Santillan D, Rai K, Santillan M, Krishnamachari Y, Salem A, Hunter S.  Efficacy of polymeric encapsulated C5a peptidase-based group B streptococcus vaccines in a murine model..  American journal of obstetrics and gynecology.  2011 September. 205(3):249.e1-8.
[PubMed]

Stegmann B, Gemmill J, Kino T, Chrousos G, Santillan D, Segars J, Stratton P.  Hypothalamic-Pituitary-Adrenal responses in women with chronic pelvic pain associated with endometriosis.  European Journal of Clinical Investigation.  2011 August. 

Santillan D, Kyser K, Santillan M, Hunter S, Cram P.  The Association Between Obstetrical Volume and Maternal Morbidity.  Poster presentation at Society of Pediatric and Perinatal Epidemiology, Montreal, Canada.  2011 June 20. 

Santillan D, Santillan M, Hamilton W, Hunter S.  Determining the Effect of Preeclampsia on Growth and Differentiation Potential of Umbilical Cord Blood Hematopoietic Stem Cells.  Poster presentation at College of Medicine Research Week, University of Iowa Hospitals and Clinics.  2011 April 14. 

Stegmann B, Santillan D, Santillan M, Van Voorhis B, Smith E.  Antimullerian Hormone Changes in Pregnancy and Prediction of Adverse Pregnancy Outcomes.  Accepted for poster presentation as Society for Gynecologic Investigation 58th Annual Meeting, Miami, FL.  2011 March. 

Santillan M, Santillan D, Hamilton W, Rayburn W, Hunter S, Leslie K.  Adaptations in Maternal Sera of Immuno-vasoactive IDO, TRAIL, and IL-4 in Response to a High sFLT-1 Preeclamptic Environment.  Accepted for poster presentation at SMFM 31st Annual Scientific Meeting, San Francisco, CA.  2011 February. 

Santillan D, Santillan M, Rai K, Hunter S.  Treatment of maternal PKU: Safety and Efficacy of a Novel Engineered Metabolic System.  Accepted for poster presentation at SMFM 31st Annual Scientific Meeting, San Francisco, CA.  2011 February. 

Santillan M, Santillan D.  2010 Updates of the CDC Guidelines for GBS in pregnancy.  Iowa Perinatal Leter.  2010 October. 31(4).

Santillan M, Pelham C, Ketsawatsomkron P, Santillan D, Yang B, Hunter S, Sigmund C.  Indoleamine 2,3 Dioxygenase (IDO) Deficiency Results in Vascular Dysfunction and Proteinuria in Pregnancy.  2010 October. 

Santillan M, Pelham C, Ketsawatsomkron P, Santillan D, Yang B, Hunter S, Sigmund C.  Development and characterization of an Indoleamine 2,3-dioxygenase (IDO) deficient mouse model of preeclampsia.  Accepted for poster presentation at SMFM 30th Annual Scientific Meeting, Chicago, IL. American Journal of Obstetrics & Gynecology.  2009 December. 201(6):S276.

Santillan D, Santillan M, Hunter S.  Cell encapsulation as a potential nondietary therapy for maternal phenylketonuria..  American journal of obstetrics and gynecology.  2009 September. 201(3):289.e1-6.
[PubMed]

Santillan M, Santillan D, Sigmund C, Hunter S.  Elucidating the Role of Indoleamine 2,3 Dioxygenase (IDO) in Preeclampsia.  2009 National Clinical Translational Research Education Annual Meeting, Washington, DC.  2009 April. 

Santillan D, Santillan M, Hunter S.  Cell Encapsulation As a Useful Non-Dietary Therapy for Maternal Phenylketonuria.  Accepted for oral presentation at SMFM 29th Annual Scientific Meeting, San Diego, CA. American Journal of Obstetrics and Gynecology.  2009 January. 199(6):S7.

Santillan M, Santillan D, Sigmund C, Hunter S.  IDO and sFLT-1: A Potential Molecular Link Between the Immune System and Preeclampsia.  Accepted for poster presentation at SMFM 29th Annual Scientific Meeting, San Diego, CA. American Journal of Obstetrics & Gynecology.  2009 January. 199(6):S83.

Chen J, Santillan D, Koonce M, Wei W, Zeleznik-Le N, Luo R, Thirman M, Diaz M.  Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization..  Cancer research.  2008 August. 68(15):6199-207.
[PubMed]

Santillan D, Andracki M, Hunter S.  Protective immunization in mice against group B streptococci using encapsulated C5a peptidase..  American journal of obstetrics and gynecology.  2008 January. 198(1):114.e1-6.
[PubMed]

Santillan D, Santillan M, Hunter S.  Development of a Novel Non-Dietary Therapy for Maternal Phenylketonuria.  Accepted for poster presentation SMFM 28th Annual Scientific Meeting, Dallas, TX. American Journal of Obstetrics & Gynecology.  2007 December. 197(6):S118.

Santillan M, Santillan D, Fleener D, Hunter S, Yankowitz J.  Single Umbilical Artery: Does SIDE Matter?.  Accepted for poster presentation SMFM 28th Annual Scientific Meeting, Dallas, TX. American Journal of Obstetrics & Gynecology..  2007 December. 197(6):S56.

Santillan M, Santillan D, Gianopoulos J, Mestril R, Koh M.  HSP60 and anti-HSP60 antibody are associated with intrapartum infection in preeclamptic mothers.  Accepted for poster presentation SMFM 28th Annual Scientific Meeting, Dallas, TX. American Journal of Obstetrics & Gynecology.  2006 December. 195(6):S141.

Santillan D, Theisler C, Ryan A, Popovic R, Stuart T, Zhou M, Alkan S, Zeleznik-Le N.  Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype..  Cancer research.  2006 October. 66(20):10032-9.
[PubMed]

Xia Z, Popovic R, Chen J, Theisler C, Stuart T, Santillan D, Erfurth F, Diaz M, Zeleznik-Le N.  The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression..  Proceedings of the National Academy of Sciences of the United States of America.  2005 September. 102(39):14028-33.
[PubMed]

Santillan D, Ryan A, Zeleznik-Le N.  MLL Partner Gene Domains Contribute Critical Functional Specificity to Immortalization and Differentiation of Hematopoietic Progenitors.  American Society of Hematology, San Diego, CA. Blood (ASH Annual Meeting Abstracts).  2004 December 4. 104:Abstract 2555.

Xia Z, Popovic R, Lorenz T, Santillan D, Erfurth F, Zeleznik-Le N.  MLL-AF4 Down-Regulates CDKN1B (P27) Independent of Cell Cycle Progression.  American Society of Hematology, San Diego, CA. Blood (ASH Annual Meeting Abstracts).  2004. 104:Abstract 2563.

Santillan D, Ryan A, Zeleznik-Le N.  Bromodomain and HAT Domain Specificity in MLL-CBP Immortalization.  FASEB Summer Conference on Hematological Malignancies, Saxtons River, VT.  2003 June. 

Santillan D, Zeleznik-Le N.  Functional Specificity of MLL-CBP.  Research Day 2002 at Edward Hines, Jr. VA Hospital, Hines, IL.  2002 April. 

Santillan D, Zeleznik-Le N.  Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein.  Curr Opin Hematol.  2001 July 8. 8(4):218-23.

Santillan D, Romas T, Crumrine D.  New Approaches to Synthesis of 3,3-Diphenyltricyclo[3.2.1.0]oct-6-enes.  30th Great Lakes Regional Meeting of the American Chemical Society. Undergraduate Poster Session. Chicago, IL..  1997 May 28. 

Date Last Modified: 06/07/2014 - 21:56:23