Neurology

Asgar Zaheer, PhD

Portrait

Specialty: Neurobiology
Associate Professor of Neurology

Contact Information

Primary Office: 431 MRC
Iowa City, IA 52242

Email: asgar-zaheer@uiowa.edu
Web: Lab Website

Education

PhD, Bombay University, India

Post Doctoral, Biochemistry, University of Iowa, Iowa City, IA

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Neuroscience

Research Summary

My laboratory has a long-term commitment to study the properties and functions of Glia Maturation Factor, a brain specific protein that we discovered in our laboratory at the Department of Neurology, the University of Iowa. My research group uses interdisciplinary approaches to understand the function of GMF and the regulation of inflammatory signaling pathways relevant to neurodegenerative diseases. I have an NIH RO1 funded program on GMF-depended neuro inflammation and neuro degeneration, an NIH RO1 funded program on GMF in CNS Inflammation and a VA Merit Review Award funded program on the role of GMF in Dementia. Our work embraces neuroimmunology, neuropathology, molecular biology, and neurochemistry. The lab is highly collaborative and multidisciplinary, offering a rich training environment in neuroscience. My laboratory has many years experience in using immunocytochemical techniques to examine tissue samples using both light and epifluorescence microscopy. I will provide any training and guidance to the best of my ability.

All Publications

Kempuraj D, Khan M, Thangavel R, Xiong Z, Yang E, Zaheer A.  Glia Maturation Factor Induces Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases..  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.  2013 February. 
[PubMed]

Khan M, Kempuraj D, Thangavel R, Zaheer A.  Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol..  Neurochemistry international.  2013 February. 62(4):379-388.
[PubMed]

Zaheer S, Thangavel R, Wu Y, Khan M, Kempuraj D, Zaheer A.  Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice..  Neurochemical research.  2013 January. 38(1):218-25.
[PubMed]

Thangavel R, Stolmeier D, Yang X, Anantharam P, Zaheer A.  Expression of glia maturation factor in neuropathological lesions of Alzheimer's disease..  Neuropathology and applied neurobiology.  2012 October. 38(6):572-81.
[PubMed]

Zaheer S, Wu Y, Yang X, Thangavel R, Sahu S, Zaheer A.  Efficient down-regulation of glia maturation factor expression in mouse brain and spinal cord..  Neurochemical research.  2012 July. 37(7):1578-83.
[PubMed]

Zaheer S, Wu Y, Yang X, Ahrens M, Sahu S, Zaheer A.  Clinical course of myelin oligodendrocyte glycoprotein 35-55 induced experimental autoimmune encephalomyelitis is aggravated by glia maturation factor..  Neurochemistry international.  2012 February. 60(3):215-9.
[PubMed]

Zaheer S, Thangavel R, Sahu S, Zaheer A.  Augmented expression of glia maturation factor in Alzheimer's disease..  Neuroscience.  2011 October. 194:227-33.
[PubMed]

Zaheer S, Wu Y, Sahu S, Zaheer A.  Suppression of neuro inflammation in experimental autoimmune encephalomyelitis by glia maturation factor antibody..  Brain research.  2011 February. 1373:230-9.
[PubMed]

Zaheer S, Wu Y, Sahu S, Zaheer A.  Overexpression of glia maturation factor reinstates susceptibility to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in glia maturation factor deficient mice..  Neurobiology of disease.  2010 December. 40(3):593-8.
[PubMed]

Thangavel R, Sahu S, Van Hoesen G, Zaheer A.  Loss of nonphosphorylated neurofilament immunoreactivity in temporal cortical areas in Alzheimer's disease..  Neuroscience.  2009 May. 160(2):427-33.
[PubMed]

Thangavel R, Van Hoesen G, Zaheer A.  The abnormally phosphorylated tau lesion of early Alzheimer's disease..  Neurochemical research.  2009 January. 34(1):118-23.
[PubMed]

Thangavel R, Van Hoesen G, Zaheer A.  Posterior parahippocampal gyrus pathology in Alzheimer's disease..  Neuroscience.  2008 June. 154(2):667-76.
[PubMed]

Zaheer A, Zaheer S, Thangavel R, Wu Y, Sahu S, Yang B.  Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage..  Brain research.  2008 May. 1208:192-203.
[PubMed]

Thangavel R, Sahu S, Van Hoesen G, Zaheer A.  Modular and laminar pathology of Brodmann's area 37 in Alzheimer's disease..  Neuroscience.  2008 March. 152(1):50-5.
[PubMed]

Zaheer A, Knight S, Zaheer A, Ahrens M, Sahu S, Yang B.  Glia maturation factor overexpression in neuroblastoma cells activates glycogen synthase kinase-3beta and caspase-3..  Brain research.  2008 January. 1190:206-14.
[PubMed]

Zaheer A, Sahu S, Traynelis V.  Inhibitors of EGFR signaling retard cytotoxicity of fenretinide in rat gliosarcoma cells..  Neurochemical research.  2008 January. 33(1):22-6.
[PubMed]

Zaheer S, Wu Y, Bassett J, Yang B, Zaheer A.  Glia maturation factor regulation of STAT expression: a novel mechanism in experimental autoimmune encephalomyelitis..  Neurochemical research.  2007 December. 32(12):2123-31.
[PubMed]

Menon K, Wu Y, Haas J, Sahu S, Yang B, Zaheer A.  Diminished degradation of myelin basic protein by anti-sulfatide antibody and interferon-gamma in myelin from glia maturation factor-deficient mice..  Neuroscience research.  2007 June. 58(2):156-63.
[PubMed]

Zaheer A, Sahu S, Wu Y, Zaheer A, Haas J, Lee K, Yang B.  Diminished cytokine and chemokine expression in the central nervous system of GMF-deficient mice with experimental autoimmune encephalomyelitis..  Brain research.  2007 May. 1144:239-47.
[PubMed]

Zaheer A, Zaheer S, Sahu S, Knight S, Khosravi H, Mathur S, Lim R.  A novel role of glia maturation factor: induction of granulocyte-macrophage colony-stimulating factor and pro-inflammatory cytokines..  Journal of neurochemistry.  2007 April. 101(2):364-76.
[PubMed]

Zaheer A, Sahu S, Ryken T, Traynelis V.  Cis-parinaric acid effects, cytotoxicity, c-Jun N-terminal protein kinase, forkhead transcription factor and Mn-SOD differentially in malignant and normal astrocytes..  Neurochemical research.  2007 January. 32(1):115-24.
[PubMed]

Zaheer A, Zaheer S, Sahu S, Yang B, Lim R.  Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice..  Neurochemical research.  2007 January. 32(1):39-47.
[PubMed]

Samuel I, Zaheer A, Fisher R.  In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production..  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.  2006 December. 10(10):1376-83.
[PubMed]

Zaheer A, Haas J, Reyes C, Mathur S, Yang B, Lim R.  GMF-knockout mice are unable to induce brain-derived neurotrophic factor after exercise..  Neurochemical research.  2006 April. 31(4):579-84.
[PubMed]

Samuel I, Zaheer S, Zaheer A.  Bile-pancreatic juice exclusion increases p38MAPK activation and TNF-alpha production in ligation-induced acute pancreatitis in rats..  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].  2005. 5(1):20-6.
[PubMed]

Samuel I, Zaheer A, Zaheer S, Fisher R.  Bile-pancreatic juice exclusion increases cholinergic M3 and CCK-A receptor expression and interleukin-6 production in ligation-induced acute pancreatitis..  American journal of surgery.  2004 November. 188(5):511-5.
[PubMed]

Lim R, Zaheer A, Khosravi H, Freeman J, Halverson H, Wemmie J, Yang B.  Impaired motor performance and learning in glia maturation factor-knockout mice..  Brain research.  2004 October. 1024(2-Jan):225-32.
[PubMed]

Zaheer A, Yang B, Cao X, Lim R.  Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes..  Neurochemical research.  2004 August. 29(8):1473-80.
[PubMed]

Samuel I, Zaheer S, Nelson J, Yorek M, Zaheer A.  CCK-A receptor induction and P38 and NF-kappaB activation in acute pancreatitis..  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].  2004. 4(1):49-56.
[PubMed]

Samuel I, Toriumi Y, Zaheer A, Joehl R.  Mechanism of acute pancreatitis exacerbation by enteral bile-pancreatic juice exclusion..  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].  2004. 4(6):527-32.
[PubMed]

Samuel I, Zaheer S, Fisher R, Zaheer A.  Cholinergic receptor induction and JNK activation in acute pancreatitis.  Am J Surg.  2003 November. 186(5):569-74.
[Link]

Samuel I, Zaheer S, Fisher R, Zaheer A.  Cholinergic receptor induction and JNK activation in acute pancreatitis..  American journal of surgery.  2003 November. 186(5):569-74.
[PubMed]

Zaheer A, Mathur S, Lim R.  Overexpression of glia maturation factor in astrocytes leads to immune activation of microglia through secretion of granulocyte-macrophage-colony stimulating factor..  Biochemical and biophysical research communications.  2002 June. 294(2):238-44.
[PubMed]

Zaheer A, Yorek M, Lim R.  Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion..  Neurochemical research.  2001 December. 26(12):1293-9.
[PubMed]

Pantazis N, Zaheer A, Dai D, Zaheer S, Green S, Lim R.  Transfection of C6 glioma cells with glia maturation factor upregulates brain-derived neurotrophic factor and nerve growth factor: trophic effects and protection against ethanol toxicity in cerebellar granule cells..  Brain research.  2000 May. 865(1):59-76.
[PubMed]

Lim R, Zaheer A, Yorek M, Darby C, Oberley L.  Activation of nuclear factor-kappaB in C6 rat glioma cells after transfection with glia maturation factor..  Journal of neurochemistry.  2000 February. 74(2):596-602.
[PubMed]

Zaheer A, Weiss J, Goyal P, Lim R.  Enhanced expression of neurotrophic factors by C6 rat glioma cells after transfection with glia maturation factor..  Neuroscience letters.  1999 April. 265(3):203-6.
[PubMed]

Lim R, Zaheer A, Kraakevik J, Darby C, Oberley L.  Overexpression of glia maturation factor in C6 cells promotes differentiation and activates superoxide dismutase..  Neurochemical research.  1998 November. 23(11):1445-51.
[PubMed]

Zaheer A, Lim R.  Overexpression of glia maturation factor (GMF) in PC12 pheochromocytoma cells activates p38 MAP kinase, MAPKAP kinase-2, and tyrosine hydroxylase..  Biochemical and biophysical research communications.  1998 September. 250(2):278-82.
[PubMed]

Li W, Zaheer A, Coppey L, Oskarsson H.  Activation of JNK in the remote myocardium after large myocardial infarction in rats..  Biochemical and biophysical research communications.  1998 May. 246(3):816-20.
[PubMed]

Zaheer A, Lim R.  Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA..  The Journal of biological chemistry.  1997 February. 272(8):5183-6.
[PubMed]

Lim R, Zaheer A.  In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor..  The Journal of biological chemistry.  1996 September. 271(38):22953-6.
[PubMed]

Zaheer A, Lim R.  In vitro inhibition of MAP kinase (ERK1/ERK2) activity by phosphorylated glia maturation factor (GMF)..  Biochemistry.  1996 May. 35(20):6283-8.
[PubMed]

Zaheer A, Zhong W, Lim R.  Expression of mRNAs of multiple growth factors and receptors by neuronal cell lines: detection with RT-PCR..  Neurochemical research.  1995 December. 20(12):1457-63.
[PubMed]

Lim R, Zaheer A.  Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor..  Biochemical and biophysical research communications.  1995 June. 211(3):928-34.
[PubMed]

Zaheer A, Zhong W, Uc E, Moser D, Lim R.  Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription-polymerase chain reaction..  Cellular and molecular neurobiology.  1995 April. 15(2):221-37.
[PubMed]

Zhong W, Zaheer A, Lim R.  Ciliary neurotrophic factor (CNTF) enhances the effects of nerve growth factor on PC12 cells..  Brain research.  1994 October. 661(2-Jan):56-62.
[PubMed]

Zaheer A, Fink B, Lim R.  Expression of glia maturation factor beta mRNA and protein in rat organs and cells..  Journal of neurochemistry.  1993 March. 60(3):914-20.
[PubMed]

Wang B, Zaheer A, Lim R.  Polyclonal antibody localizes glia maturation factor beta-like immunoreactivity in neurons and glia..  Brain research.  1992 September. 591(1):7-Jan.
[PubMed]

Keles G, Berger M, Lim R, Zaheer A, Denton A, Silber J.  Expression of glial fibrillary acidic protein in human medulloblastoma cells treated with recombinant glia maturation factor-beta..  Oncology research.  1992. 4(10):431-7.
[PubMed]

Harman K, Katnick J, Lim R, Zaheer A, de la Torre J.  Glia maturation factor beta stimulates axon regeneration in transected rat sciatic nerve..  Brain research.  1991 November. 564(2):332-5.
[PubMed]

Kaplan R, Zaheer A, Jaye M, Lim R.  Molecular cloning and expression of biologically active human glia maturation factor-beta..  Journal of neurochemistry.  1991 August. 57(2):483-90.
[PubMed]

Lim R, Zaheer A.  Structure and function of glia maturation factor beta..  Advances in experimental medicine and biology.  1991. 296:161-4.
[PubMed]

Lim R, Liu Y, Zaheer A.  Cell-surface expression of glia maturation factor beta in astrocytes..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology.  1990 December. 4(15):3360-3.
[PubMed]

Lim R, Zhong W, Zaheer A.  Antiproliferative function of glia maturation factor beta..  Cell regulation.  1990 September. 1(10):741-6.
[PubMed]

Zaheer A, Lim R.  Disulfide isoforms of recombinant glia maturation factor beta..  Biochemical and biophysical research communications.  1990 September. 171(2):746-51.
[PubMed]

Lim R, Zaheer A, Lane W.  Complete amino acid sequence of bovine glia maturation factor beta..  Proceedings of the National Academy of Sciences of the United States of America.  1990 July. 87(14):5233-7.
[PubMed]

Lim R, Liu Y, Zaheer A.  Glia maturation factor beta regulates the growth of N18 neuroblastoma cells..  Developmental biology.  1990 February. 137(2):444-50.
[PubMed]

Lim R, Miller J, Zaheer A.  Purification and characterization of glia maturation factor beta: a growth regulator for neurons and glia..  Proceedings of the National Academy of Sciences of the United States of America.  1989 May. 86(10):3901-5.
[PubMed]

Zaheer A, Zaheer S, Montgomery R.  Peptidase activity of macromomycin apoprotein..  The Journal of biological chemistry.  1985 September. 260(21):11787-92.
[PubMed]

Zaheer A, Zaheer S, Montgomery R.  Proteolytic activity of largomycin..  Biochimica et biophysica acta.  1985 September. 841(3):261-6.
[PubMed]

Vandré D, Zaheer A, Squier S, Montgomery R.  Largomycin: preparation, properties, and structure..  Biochemistry.  1982 September. 21(20):5089-96.
[PubMed]

Zaheer A, Singh D, Montgomery R.  (Na (+) + K (+)-stimulated ATPase of human kidney, normal and adenocarcinoma. Phosphorylation and inhibition by antitumor proteins..  Biochemical and biophysical research communications.  1981 September. 102(1):86-92.
[PubMed]

Zaheer A, Elting J, Montgomery R.  (Na+ + K+)-stimulated ATPase inhibition by cesalin and macromomycin..  The Journal of biological chemistry.  1981 February. 256(4):1786-92.
[PubMed]

Zaheer A, Braganca B.  The (Na+ + K+)-stimulated ATP-A from Yoshida sarcoma ascitic tumor cells--comparison of the properties of partially purified and highly purified enzyme..  Cellular and molecular biology, including cyto-enzymology.  1981. 27(4):387-90.
[PubMed]

Zaheer A, Braganca B.  Comparative study of three basic polypeptides from snake venoms in relation to their effects on the cell membrane of normal and tumor cells..  Cancer biochemistry biophysics.  1980. 5(1):41-6.
[PubMed]

Joshi S, Zaheer A, Korgaonkar K.  Gamma-irradiation studies with synthetic poly-L-serine in the megarad dose range..  Cancer biochemistry biophysics.  1980. 4(3):153-7.
[PubMed]

Ambani L, Murthy D, Zaheer A, Fialho M.  Nonketotic hyperglycinemia in two siblings..  Indian pediatrics.  1979 May. 16(5):455-8.
[PubMed]

Mone M, Zaheer A, Fialho M, Braganca B.  Inactivation of membrane-bound (Na+ +K+)-ATPase of Yoshida sarcoma cells and cobra venom cytotoxin complex with the glycolipid components of the enzyme system..  Cancer biochemistry biophysics.  1979. 4(1):37-41.
[PubMed]

Zaheer A, Iyer S, Braganca B.  Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Yoshida sarcoma cells by inhibitor proteins from cobra venom..  Cancer biochemistry biophysics.  1979. 3(3):123-7.
[PubMed]

Zaheer A, Kakirde M, Braganca B.  Purification and characterisation of (Na+ + K+)-stimulated ATP-A from Yoshida sarcoma ascitic tumour cells..  Cellular and molecular biology, including cyto-enzymology.  1979. 24(4):341-6.
[PubMed]

Zaheer A, Noronha S, Hospattankar A, Braganca B.  Inactivation of (Na-++K-+)-stimulated ATPase by a cytotoxic protein from cobra venom in relation to its lytic effects on cells..  Biochimica et biophysica acta.  1975 June. 394(2):293-303.
[PubMed]

Samuel I, Yorek M, Zaheer A, Fisher R.  Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis..  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.  10(7):950-9.
[PubMed]

Date Last Modified: 09/08/2014 - 14:32:14