Michael Wall, MD


Director, Neuro-Ophthalmology Clinic, Neurology
Professor of Neurology
Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 2149 RCP
Iowa City, IA 52242



MD, Medicine, Tulane University

Residency, Neurology, Washington University in St. Louis
Fellowship, Neuro-ophthalmology, Harvard University

Research Summary

Dr. Wall's research has two arms. The first is to develop strategies of visual field testing that detect visual field defects at an earlier stage and visual field change at an earlier time. To achieve these goals, we have been studying mechanisms of perimetric variability. We have been funded for this with a VA Merit review for the past 12 years. During this time we have shown that a substantial portion of the variability of perimetry is due to the stimulus size chosen. In the process, we have developed a method of visual field testing, motion perimetry, that takes advantage of these findings to lower retest variability. We are in the fourth year of a 5 year study that follows glaucoma patients with four visual field tests to determine if larger stimuli result in earlier detection of visual field change. The second arm of the research is to study idiopathic intracranial hypertension (pseudotumor cerebri) a disease of overweight women in the childbearing years that causes headache and blindness. Our goal is to find the cause of the disease and to develop evidence-based treatment strategies. Currently all treatment decisions are based on data that is retrospective and uncontrolled. Our clinical trial has now been funded by the NIH for $16 million over 5 years. The specific aims of 1) determining if diet and acetazolamide is superior to diet alone; 2) with the help of Edwin Stone's laboratory, using a genome wide association study better understand the mechanism of idiopathic intracranial hypertension.

Selected Publications

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Wall M, Falardeau J, Fletcher W, Granadier R, Lam B, Longmuir R, Patel A, Bruce B, He H, McDermott M.  Risk factors for poor visual outcome in patients with idiopathic intracranial hypertension.  Neurology.  2015 September 1. 85(9):799-805.

Nordic Idiopathic Intracranial Hypertension Study Group Writing Committee , Wall M, McDermott M, Kieburtz K, Corbett J, Feldon S, Friedman D, Katz D, Keltner J, Schron E, Kupermsith M.  Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial.  JAMA.  2014. 311(16):1641-51.

Wall M, Kupersmith M, Kieburtz K, Corbett J, Feldon S, Friedman D, Katz D, Keltner J, Schron E, McDermott M, Nordic Idiopatic Intracranial Hypertension Study Group .  The idiopathic intracranial hypertension treatment trial: clinical profile at baseline.  JAMA Neurology.  2014. 71(6):693-701.

Wall M.  Idiopathic intracranial hypertension and the idiopathic intracranial hypertension treatment trial.  J Neuroophthalmol.  2013. 33(1):1-3.

Wall M, Doyle C, Eden T, Zamba K, Johnson C.  Size Threshold Perimetry Performs as well as Conventional Automated Perimetry with Stimulus Sizes III, V and VI for Glaucomatous Loss.  Invest Ophthalmol Vis Sci.  2013. 54(6):3975-83.

Wall M, Doyle C, Zamba K, Artes P, Johnson C.  The Repeatability of Mean Defect with Size III and Size V Standard Automated Perimetry.  Invest Ophthalmol Vis Sci.  2013. 54(2):1345-51.

Wall M, Woodward K, Doyle C, Zamba G.  The Effective Dynamic Ranges of Standard Automated Perimetry Sizes III and V and Motion and Matrix Perimetry.  Arch Ophthalmol.  2010. 128(5):570-6.

Wall M, Woodward K, Doyle C, Artes P.  Repeatability of Automated Perimetry: A Comparison between Standard Automated Perimetry with Stimulus Size III and V, Matrix, and Motion Perimetry.  Invest Ophthalmol Vis Sci.  2009. 50(2):974-9.

Shah V, Kardon R, Lee A, Corbett J, Wall M.  Long-term follow-up of idiopathic intracranial hypertension: The Iowa experience.  Neurology.  2008. 70(8):634-40.

Wall M, Brito C, Woodward K, Doyle C, Kardon R, Johnson C.  Total Deviation Probability Plots for Stimulus Size V Perimetry: A Comparison With Size III Stimuli.  Arch Ophthalmol.  2008. 126(4):473-9.

Date Last Modified: 08/04/2015 - 09:28:35