William Talman, MD


Specialty: Autonomic Disorders
Director, VA Medical Center Program, Neurology
Professor of Neurology

Contact Information

Primary Office: S209 GH
Iowa City, IA 52242
Phone: 319-356-8750

Web: Neurobiology and Circulatory Control Laboratory


BA, Virginia Military Institute
MD, University of Virginia School of Medicine

Fellowship, Neurology, Cornell University
Internship, Internal Medicine, Case Western Reserve University
Residency, Internal Medicine, Case Western Reserve University
Residency, Neurology, Cornell University

Licensure and Certifications

State of New Jersey
State of New York
State of Iowa
State of Virginia License

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

Cardiovascular regulation by the CNS. pharmacology, neuroanatomy, immunohistochemistry, physiology, baroreflex, dominant negative, neurotransmitter, cerebral blood flow, neurogenic hypertension, glutamate, nitric oxide, cardiovascular Our laboratory research focuses on central cardiovascular and circulatory control. We study the role played by excitatory amino acids and nitric oxide as possible neurotransmitters in central cardiovascular reflex signal transduction. Current studies investigate the link between activation of excitatory amino acid receptors and release of nitric oxide in specific nuclei of the brain stem. In separate studies we investigate the role played by arterial baroreceptor reflexes in cerebrovascular control. Those studies focus on the role played by nitroxidergic parasympathetic nerves in cerebrovascular control and on the preganglionic central pathways that regulate those nerves.

Selected Publications

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Lin L, Jin J, Nashelsky M, Talman W.  Acid-sensing ion channel 1 and nitric oxide synthase are in adjacent layers in the wall of rat and human cerebral arteries..  Journal of chemical neuroanatomy.  2014 November 1. 61-62:161-8.

Lin L, Moore S, Jones S, McGlashon J, Talman W.  Astrocytes in the rat nucleus tractus solitarii are critical for cardiovascular reflex control..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2013 November 20. 33(47):18608-17.

Talman W, Lin L.  Sudden death following selective neuronal lesions in the rat nucleus tractus solitarii..  Autonomic neuroscience : basic & clinical.  2013 April 1. 175(1-2):9-16.

Talman W, Dragon D, Jones S, Moore S, Lin L.  Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat..  Cellular and molecular neurobiology.  2012 October 1. 32(7):1119-26.

Lin L, Nitschke Dragon D, Jin J, Tian X, Chu Y, Sigmund C, Talman W.  Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat..  The Journal of physiology.  2012 August 1. 590(Pt 15):3545-59.

Talman W.  Views of translational research from a somewhat translational scientist..  Journal of investigative medicine : the official publication of the American Federation for Clinical Research.  2012 August 1. 60(6):863-8.

Hobin J, Deschamps A, Bockman R, Cohen S, Dechow P, Eng C, Galey W, Morris M, Prabhakar S, Raj U, Rubenstein P, Smith J, Stover P, Sung N, Talman W, Galbraith R.  Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles..  Journal of translational medicine.  2012 April 13. 10:72.

Lin L, Nitschke Dragon D, Talman W.  Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat..  Journal of chemical neuroanatomy.  2012 March 1. 43(2):141-8.

Nazarali A, Talman W.  Special Issue on A Tribute to Marshall Nirenberg. Introduction..  Cellular and molecular neurobiology.  2011 August 1. 31(6):803.

Lin L, Dragon D, Jin J, Talman W.  Targeting neurons of rat nucleus tractus solitarii with the gene transfer vector adeno-associated virus type 2 to up-regulate neuronal nitric oxide synthase..  Cellular and molecular neurobiology.  2011 August 1. 31(6):847-59.

Date Last Modified: 10/09/2015 - 15:23:31