Neurology

Ana Recober, MD

Portrait

Specialty: Headache
Director: Headache Clinic
Assistant Professor of Neurology

Contact Information

Primary Office: 1042 ML ML
25 South Grand Avenue
Iowa City, IA 52242
Primary Office Phone: 319-356-8753

Email: ana-recober@uiowa.edu

Education

MD, University of Malaga Medical School, Malaga, Spain

Residency, Neurology, University of Iowa, Iowa City, IA
Fellowship, Headache and Pain, University of Iowa, Iowa City, IA

Licensure and Certifications

United Council for Neurologic Subspecialties: Headache Medicine Certification
American Board of Psychiatry and Neurology
Iowa Board of Medical Examiners
Iowa Controlled Substance DEA
Educational Commission for Foreign Medical Graduates

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

The focus of my laboratory is the study of the biological mechanisms underlying the progression from episodic to chronic migraine, a poorly understood phenomenon we frequently observe in the clinic. Multiple culprits have been implicated in this process, but little is known about the relevant cellular and molecular changes involved in this progression. Clarifying these links is crucial to discovering novel therapeutic targets aimed to preventing chronic migraines. I use behavioral, pharmacological, molecular and cellular techniques to elucidate the mechanisms responsible for the link between migraine and two common conditions that are associated with chronic migraine, obesity and sleep disorders. My central hypothesis is that these disorders lead to chronic migraine by enhancing central sensitization in the trigeminal nucleus caudalis. I use animal models of these conditions to determine the role of the calcitonin gene-related peptide (CGRP) and several cytokines in the trigeminovascular pathway. In addition to these mechanistic studies, I am also studying the effects of childhood obesity in adults with migraine in the Muscatine Heart Study Cohort and I am exploring the effects of weight loss in migraine attack frequency and severity in humans.

All Publications

Rossi H, Luu K, DeVilbiss J, Recober A.  Obesity lowers the threshold of trigeminal activation: Implications for migraine.  European Journal of Pain.  2013 May. 17(5):649-653.
[PubMed]

Rossi H, Luu A, Kothari S, Kuburas A, Neubert J, Caudle R, Recober A.  Effects of diet-induced obesity on motivation and pain behavior in an operant assay.  Neuroscience.  2013 April. 235:87-95.
[PubMed]

Recober A, Kruger J, Hoang-Tienor A, Burns T.  Cardiovascular Profile and the Risk of Migraine in Adulthood.  International Headache Congress Platform presentation # OR25, Boston, MA.  2013. 

Recober A, Luu A, Rossi H, Kothari S, Lara O.  Photophobia in Obese Mice: Implications for Migraine.  International Headache Congress Abstract #P318, Boston, MA.  2013. 

Recober A, Luu A, Rossi H, Kothari S, Lara O.  Trigeminal Pain is Increased by High-Fat Diet Induced Obesity in Mice.  International Headache Congress Abstract #P309, Boston, MA.  2013. 

Kaiser E, Kuburas A, Recober A, Russo A.  Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT(1B/D) agonist.  The Journal of Neuroscience.  2012 October. 32(44):15439-49.
[PubMed]

Rossi H, Luu A, Devilbiss J, Recober A.  Obesity increases nociceptive activation of the trigeminal system..  European journal of pain (London, England).  2012 October. 
[PubMed]

Dindo L.  This week’s key opinion leader. A one-day treatment workshop for comorbid migraine and depression.  Psychiatry Weekly.  2012 September 3. 7(17):1.

Dindo L, Recober A, Marchman J, Turvey C, O'Hara M.  One-day behavioral treatment for patients with comorbid depression and migraine: a pilot study..  Behaviour research and therapy.  2012 September. 50(9):537-43.
[PubMed]

VanDenBrink A, Ferrari M.  Current literature: Clinical science. Serotonin, NO, and CGRP and Headache.  Headache.  2011 June. 51(6):1047-8.

Thompson S, Recober A, Vogel T, Kuburas A, Owens J, Sheffield V, Russo A, Stone E.  Light aversion in mice depends on nonimage-forming irradiance detection..  Behavioral neuroscience.  2010 December. 124(6):821-7.
[PubMed]

Schwedt T, Goadsby P.  14th International Headache Congress: Basic Science Highlights.  Headache.  2010 March. 50(3):520-6.

Recober A, Goadsby P.  Calcitonin gene-related peptide: A molecular link between obesity and migraine?.  Drug news & perspectives.  2010 March. 23(2):112-7.
[PubMed]

Rossi H, Hammond D, Recober A.  Effect of Sleep Deprivation on Trigeminally-mediated Pain and on Activation of the Trigeminal Nucleus Caudalis in Mice.  Society for Neuroscience Abstract # 679.29, San Diego, CA.  2010. 

Kuburas A, Rossi H, Russo A, Recober A.  Studying the Effects of Obesity in Migraine.  Society for Neuroscience Abstract # 80.16, San Diego, CA.  2010. 

Tietjen G, Brandes J, Peterlin B, Eloff A, Dafer R, Stein M, Drexler E, Martin V, Hutchinson S, Aurora S, Recober A, Herial N, Utley C, White L, Khuder S.  Childhood maltreatment and migraine (part I). Prevalence and adult revictimization: a multicenter headache clinic survey..  Headache.  2010 January. 50(1):20-31.
[PubMed]

Tietjen G, Brandes J, Peterlin B, Eloff A, Dafer R, Stein M, Drexler E, Martin V, Hutchinson S, Aurora S, Recober A, Herial N, Utley C, White L, Khuder S.  Childhood maltreatment and migraine (part II). Emotional abuse as a risk factor for headache chronification..  Headache.  2010 January. 50(1):32-41.
[PubMed]

Tietjen G, Brandes J, Peterlin B, Eloff A, Dafer R, Stein M, Drexler E, Martin V, Hutchinson S, Aurora S, Recober A, Herial N, Utley C, White L, Khuder S.  Childhood maltreatment and migraine (part III). Association with comorbid pain conditions..  Headache.  2010 January. 50(1):42-51.
[PubMed]

Recober A, Kaiser E, Kuburas A, Russo A.  Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP..  Neuropharmacology.  2010 January. 58(1):156-65.
[PubMed]

Tietjen G, Brandes J, Peterlin B, Eloff A, Dafer R, Stein M, Drexler E, Martin V, Hutchinson S, Aurora S, Recober A, Herial N, Utley C, White L, Khuder S.  Allodynia in migraine: association with comorbid pain conditions..  Headache.  2009 October. 49(9):1333-44.
[PubMed]

Headache: Mice shed light on photophobia and migraine.  Nature Reviews Neurology.  2009 September. 5(9):465.

Faculty of 1000 Medicine evaluation of the article “Role of calcitonin gene-related peptide in light aversive behavior: implications for migraine”.  The Journal of Neuroscience.  2009 July 8. 29(27):8798-804.
[Link]

Recober A, Kuburas A, Zhang Z, Wemmie J, Anderson M, Russo A.  Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2009 July. 29(27):8798-804.
[PubMed]

Recober A, Russo A.  Calcitonin gene-related peptide: an update on the biology..  Current opinion in neurology.  2009 June. 22(3):241-6.
[PubMed]

Russo A, Kuburas A, Kaiser E, Raddant A, Recober A.  A Potential Preclinical Migraine Model: CGRP-Sensitized Mice..  Molecular and cellular pharmacology.  2009. 1(5):264-270.
[PubMed]

Recober A, Kaiser E, Zhang Z, Wemmie J, Anderson M, Russo A.  CGRP-induced photophobia blocked by olcegepant and rizatriptan in a transgenic migraine model.  14th International Headache Congress, Philadelphia, PA.  2009. 

Recober A, Kuburas A, Zhang Z, Russo A.  A potential migraine model: hRAMP1 transgenic mouse.  Society for Neuroscience Abstract # 369, Washington DC.  2008. 

Recober A, Kuburas A, Zhang Z, Russo A.  Developing a potential migraine mouse model: hRAMP1 transgenic mice.  American Academy of Neurology 60th Annual Meeting, Chicago, IL.  2008. 

Tietjen G, Brandes J, Digre K, Baggaley S, Martin V, Recober A, Geweke L, Hafeez F, Aurora S, Herial N, Utley C, Khuder S.  History of childhood maltreatment is associated with comorbid depression in women with migraine..  Neurology.  2007 September. 69(10):959-68.
[PubMed]

Recober A, Russo A.  Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment..  IDrugs : the investigational drugs journal.  2007 August. 10(8):566-74.
[PubMed]

Recober A, Russo A.  Anti-Migraine Medications.  Wiley and Sons.  2007. 

Recober A, Kuburas A, Zhang Z, Russo A.  Developing a potential migraine mouse model: Photophobia.  Society for Neuroscience Abstracts 71.6, San Diego, CA.  2007. 

Marquez de Prado B, Recober A, Zhang Z, Hammond D, Russo A.  Mechanical and thermal nociception in a potential migraine mouse model.  Society for Neuroscience Abstracts 181.7, San Diego, CA.  2007. 

Tietjen G, Brandes J, Digre K, Baggaley S, Martin V, Recober A, Geweke L, Hafeez F, Aurora S, Herial N, Utley C, Khuder S.  High prevalence of somatic symptoms and depression in women with disabling chronic headache..  Neurology.  2007 January. 68(2):134-40.
[PubMed]

Recober A, Geweke L.  Menstrual migraine..  Current neurology and neuroscience reports.  2005 March. 5(2):93-8.
[PubMed]

Recober A, Geweke L.  Bilateral spontaneous carotid cavernous sinus fistulae presenting as migraine headache.  45th Annual Scientific Meeting of the American Headache Society, Chicago, IL.  2003. 

Gonzalez-Alegre P, Recober A, Kelkar P.  Idiopathic brachial neuritis.  The Iowa orthopaedic journal.  2002. 22:81-5.
[PubMed]

Recober A, Rodnitzky R, Dobson J.  Association between childhood passive exposure to tobacco smoke and Parkinson’s disease.  XIV International Congress on Parkinson's Disease. Helsinki, Finland.  2001. 

Gonzalez-Alegre T, Recober A, Valdivielso P, Garcia-Arias C, Gonzalez-Santos P.  Diabetes Mellitus and Coronary Disease.  X National Congress of The Spanish Society of Arteriosclerosis.  1997. 9(1).

Dindo L, Recober A, Marchman J, O'Hara M, Turvey C.  Impact of a One-Day Behavioral Intervention on Headaches: A Pilot Study in Depressed Migraine Patients.  Headache. 

Hoffmann J, Recober A.  Migraine and triggers: Post hoc ergo propter hoc?.  Current Pain and Headache Reports. 

Researchers shed light on photophobia.  National Institute of Dental and Craniofacial Research (NIH/NIDCR) Website. 
[Link]

Russo A, Recober A, Zhang Z, Marquez de Prado B, Kaiser E, Kuburas A.  Role of calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) in migraine.  Oxford University Press.  18.

Russo A, Recober A.  What is Photophobia?.  Headache Currents. 

Date Last Modified: 06/07/2014 - 21:56:23