Michael E. Shy, MD


Specialty: Neuromuscular Disease
Director, Division of Neuromuscular Medicine, Neurology
Professor of Neurology
Professor of Pediatrics

Contact Information

Office: 2157 RCP
Iowa City, IA 52242
Office Phone: 319-384-5094



BA, History, University of Pennsylvania, Philadelphia, Pennsylvania
MD, Medicine, Albany Medical College, Albany, New York

Internship, Internal Medicine, Albany Medical Center, Albany, New York
Residency, Columbia Presbyterian Medical Center, New York, New York
NINCDS, Clinical Neuroscience Training Program, Columbia Presbyterian Medical Center
Fellowship, Neuroimmunology, Muscular Dystrophy Association
Attending Neurologist, Neurology, Columbia Presbyterian Medical Center

Licensure and Certifications

MD license
MD license
Board Certified in Neurology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

My professional interests involve translational research to develop rational therapies for patients with inherited peripheral neuropathies and related neurodegenerative diseases.

Selected Publications

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Patzkó A, Bai Y, Saporta M, Katona I, Wu X, Vizzuso D, Feltri M, Wang S, Dillon L, Kamholz J, Kirschner D, Sarkar F, Wrabetz L, Shy M.  Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice..  Brain : a journal of neurology.  2012 December. 135(Pt 12):3551-66.

Shy M, Prada V, Passalacqua M, Bono M, Luzzi  P, Scazzola S, Nobbio L, Capponi  S, Bellone E, Mandich P, Mancardi G, Schenone A, Grandis M.  Gain of glycosylation: a new pathomechanism of myelin protein zero mutations.  Annals of neurology.  2012. 71:427-431.

Shy M.  Lessons from London. Journal of neurology, neurosurgery, and psychiatry.  2012. 

Shy M, Saporta M, Shy B, Patzko A, Bai Y, Pennuto M, Ferri C, Tinelli E, Saveri P, Kirschner  D, Crowther M, Southwood C, Wu X, Gow A, Feltri M, Wrabetz L.  MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B.  Brain.  2012. 135:2032-2047.

Shy M, Burns J, Ramchandren S, Ryan M, Ouvrier R.  Determinants of reduced health related quality of life in pediatric inherited neuropathies.  Neurology.  2010. 75:726-731.

Shy M, Kamholz J, Brucal M, Li J.  Myelin Protein Zero and CMT1B: a tale of two phenotypes.  Elsevier Press.  2007. 

Paulson H, Garbern J, Hoban T, Krajewski K, Lewis R, Fischbeck K, Grossman R, Lenkinski R, Kamholz J, Shy M.  Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease..  Annals of neurology.  2002 October. 52(4):429-34.

Shy M, Paulson H, Hoban T, Krajewski K, Garbern J, Lewis  R, Fischbeck K, Grossman R, Kamholz J.  Transient CNS white matter abnormality in X-linked Charcot-Marie-Tooth disease.  Ann Neurol.  2002. 52:429-434.

Shy M, Bird S, Brown M, Scherer S.  Autoimmune Demyelination Neuropathy Associated With Malignant Melanoma.  Neurology.  1996. 46:822-824.

Shy M, Freddo L, Hays A, Nickerson K, Spatz  L, McGinnis S, Lieberson R, Vedeler C, Autilio-Gambetti  T, Grauss F, Petito F, Chess L, Latov N.  Monoclonal anti-DNA IgM in Neuropathy Binds to Myelin and to Conformational Epitope Formed by Phosphatidic Acid and Gangliosides.  J. Immunol. .  1986. 137:3281-3826.

Date Last Modified: 07/16/2014 - 14:49:02