Michael Shy, MD


Attending Neurologist
Specialty: Neuromuscular Disease
Director, Division of Neuromuscular Medicine, Neurology
Professor of Neurology
Professor of Pediatrics, Molecular Physiology and Biophysics

Contact Information

Office: 2157 RCP
Iowa City, IA 52242
Phone: 319-384-5094



BA, History, University of Pennsylvania
MD, Medicine, Albany Medical College

Internship, Internal Medicine, Albany Medical Center
Residency, Columbia Presbyterian Medical Center
Fellowship, Clinical Neuroscience Training Program, Columbia Presbyterian Medical Center
Fellowship, Neuroimmunology, Muscular Dystrophy Association

Licensure and Certifications

Iowa MD license
Michigan MD license
Board Certified in Neurology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience

Research Summary

My professional interests involve translational research to develop rational therapies for patients with inherited peripheral neuropathies and related neurodegenerative diseases.

Selected Publications

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Jerath N, Kamholz J, Grider T, Harper A, Swenson A, Shy M.  Coexistence of a T118M PMP22 missense mutation and chromosome 17 (17p11.2-p12) deletion..  Muscle & nerve.  2015 November 1. 52(5):905-8.

Sanmaneechai O, Feely S, Scherer S, Herrmann D, Burns J, Muntoni F, Li  J, Siskind C, Day J, Laura M, Sumner C, Lloyd T, Ramchandren S, Shy R, Grider T, Bacon C, Finkel R, Yum S, Moroni I, Piscosquito G, Pareyson D, Reilly M, Shy M.  Genotype-phenotype characteristics and baseline natural history of heritable neuropathies caused by mutations in the MPZ gene..  Brain : a journal of neurology.  2015 November 1. 138(Pt 11):3180-92.

Manganelli F, Nolano M, Pisciotta C, Provitera V, Fabrizi G, Cavallaro T, Stancanelli A, Caporaso G, Shy M, Santoro L.  Charcot-Marie-Tooth disease: New insights from skin biopsy..  Neurology.  2015 October 6. 85(14):1202-8.

Brennan K, Bai Y, Pisciotta C, Wang S, Feely S, Hoegger M, Gutmann L, Moore S, Gonzalez M, Sherman D, Brophy P, Züchner S, Shy M.  Absence of Dystrophin Related Protein-2 disrupts Cajal bands in a patient with Charcot-Marie-Tooth disease..  Neuromuscular disorders : NMD.  2015 October 1. 25(10):786-93.

Gutmann L, Shy M.  Update on Charcot-Marie-Tooth disease..  Current opinion in neurology.  2015 October 1. 28(5):462-7.

Strickland A, Schabhüttl M, Offenbacher H, Synofzik M, Hauser N, Brunner-Krainz M, Gruber-Sedlmayr U, Moore S, Windhager R, Bender B, Harms M, Klebe S, Young P, Kennerson M, Garcia A, Gonzalez M, Züchner S, Schule R, Shy M, Auer-Grumbach M.  Mutation screen reveals novel variants and expands the phenotypes associated with DYNC1H1..  Journal of neurology.  2015 September 1. 262(9):2124-34.

Gonzaga-Jauregui C, Harel T, Gambin T, Kousi M, Griffin L, Francescatto L, Ozes B, Karaca E, Jhangiani S, Bainbridge M, Lawson K, Pehlivan D, Okamoto Y, Withers M, Mancias P, Slavotinek A, Reitnauer P, Goksungur M, Shy M, Crawford T, Koenig M, Willer J, Flores B, Pediaditrakis I, Us O, Wiszniewski W, Parman Y, Antonellis A, Muzny D, Katsanis N, Battaloglu E, Boerwinkle E, Gibbs R, Lupski J.  Exome Sequence Analysis Suggests that Genetic Burden Contributes to Phenotypic Variability and Complex Neuropathy..  Cell reports.  2015 August 18. 12(7):1169-83.

Fridman V, Bundy B, Reilly M, Pareyson D, Bacon C, Burns J, Day J, Feely S, Finkel R, Grider T, Kirk C, Herrmann D, Laurá M, Li  J, Lloyd T, Sumner C, Muntoni F, Piscosquito G, Ramchandren S, Shy R, Siskind C, Yum S, Moroni I, Pagliano E, Zuchner S, Scherer S, Shy M.  CMT subtypes and disease burden in patients enrolled in the Inherited Neuropathies Consortium natural history study: a cross-sectional analysis..  Journal of neurology, neurosurgery, and psychiatry.  2015 August 1. 86(8):873-8.

Pisciotta C, Bai Y, Brennan K, Wu X, Grider T, Feely S, Wang S, Moore S, Siskind C, Gonzalez M, Zuchner S, Shy M.  Reduced neurofilament expression in cutaneous nerve fibers of patients with CMT2E..  Neurology.  2015 July 21. 85(3):228-34.

Jerath N, Shy M, Grider T, Gutmann L.  A case of neuromyotonia and axonal motor neuropathy: A report of a HINT 1 mutation in the United States..  Muscle & nerve.  2015 July 16. 

Date Last Modified: 08/27/2015 - 13:23:08