Neurology

George Richerson, MD, PhD

Portrait

Specialty: Breathing Control Disorders
The Roy J. Carver Chair in Neuroscience
Director: Clinical Neuroscientist Training Program in Neurology
Head, Department of Neurology
Professor of Neurology
Professor of Molecular Physiology and Biophysics

Contact Information

Primary Office: 2151-A1 RCP
Iowa City, IA 52242
Phone: 319-356-4296

Lab: 1000 ML
Iowa City, IA 52242

Email: george-richerson@uiowa.edu
Web: Richerson Laboratory

Education

BS, Aerospace Engineering, Iowa State University
MD, Medicine, University of Iowa
PhD, Molecular Physiology and Biophysics, University of Iowa

Internship, Waterbury Hospital Health Center
Residency, Neurology Chief Resident, Yale-New Haven Hospital

Licensure and Certifications

Physician's and Surgeon's License, Connecticut Board of Health
Physician's and Surgeon's License, Iowa Board of Medicine
Diplomate, American Board of Psychiatry and Neurology

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Sudden death in epilepsy (SUDEP) and infants (SIDS), GABA mechanisms in epilepsy, Non-motor symptoms of Parkinson's disease, Control of breathing, Sleep, Serotonin, Brainstem mechanisms

All Publications

Cerpa V, Aylwin M, Beltrán-Castillo S, Bravo E, Llona I, Richerson G, Eugenín J.  Prenatal-perinatal Nicotine Alters Neonatal Raphe Neurons: Meaning for Sudden Infant Death Syndrome.  American journal of respiratory cell and molecular biology.  2015 February 19. 
[PubMed]

Massey C, Iceman K, Johansen S, Wu Y, Harris M, Richerson G.  Isoflurane abolishes spontaneous firing of serotonin neurons and masks their pH/CO2 chemosensitivity.  Journal of neurophysiology.  2015 February 18. 
[PubMed]

Brust R, Corcoran A, Richerson G, Nattie E, Dymecki S.  Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics.  Cell reports.  2014 December 24. 9(6):2152-65.
[PubMed]

Cerpa V, Gonzalez A, Richerson G.  Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception.  Neuroscience.  2014 October 24. 279:65-76.
[PubMed]

Buchanan G, Murray N, Hajek M, Richerson G.  Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality.  The Journal of physiology.  2014 October 1. 592(Pt 19):4395-410.
[PubMed]

Massey C, Sowers L, Dlouhy B, Richerson G.  Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention.  Nature reviews. Neurology.  2014 May 1. 10(5):271-82.
[PubMed]

Price M, Gong H, Parsons M, Kundert J, Reznikov L, Bernardinelli L, Chaloner K, Buchanan G, Wemmie J, Richerson G, Cassell M, Welsh M.  Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli.  Genes, brain, and behavior.  2014 February 1. 13(2):179-94.
[PubMed]

Corcoran A, Commons K, Wu Y, Smith J, Harris M, Richerson G.  Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2014 January 1. 34(1):51-9.
[PubMed]

Teran F, Massey C, Richerson G.  Serotonin neurons and central respiratory chemoreception: where are we now?.  Progress in brain research.  2014 January 1. 209:207-33.
[PubMed]

Iceman K, Richerson G, Harris M.  Medullary serotonin neurons are CO2 sensitive in situ.  Journal of neurophysiology.  2013 December 1. 110(11):2536-44.
[PubMed]

Sowers L, Massey C, Gehlbach B, Granner M, Richerson G.  Sudden unexpected death in epilepsy: fatal post-ictal respiratory and arousal mechanisms.  Respiratory physiology & neurobiology.  2013 November 1. 189(2):315-23.
[PubMed]

Sowers L, Loo L, Wu Y, Campbell E, Ulrich J, Wu S, Paemka L, Wassink T, Meyer K, Bing X, El-Shanti H, Usachev Y, Ueno N, Manak J, Shepherd A, Ferguson P, Darbro B, Richerson G, Mohapatra D, Wemmie J, Bassuk A.  Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction.  Molecular psychiatry.  2013 October 1. 18(10):1077-89.
[PubMed]

Massey C, Kim G, Corcoran A, Haynes R, Paterson D, Cummings K, Dymecki S, Richerson G, Nattie E, Kinney H, Commons K.  Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice..  Journal of neurochemistry.  2013 September 1. 126(6):749-57.
[PubMed]

Richerson G.  Serotonin: The Anti-SuddenDeathAmine?.  Epilepsy currents / American Epilepsy Society.  2013 September 1. 13(5):241-4.
[PubMed]

Corcoran A, Richerson G, Harris M.  Serotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ..  Respiratory physiology & neurobiology.  2013 April 1. 186(2):214-20.
[PubMed]

Ransom C, Tao W, Wu Y, Spain W, Richerson G.  Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons..  Journal of neurophysiology.  2013 February 1. 109(3):803-12.
[PubMed]

Bravata D, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight H, Lo  A, Richerson G, Gorman M, Williams L, Brass L, Agostini J, Mohsenin V, Roux F, Yaggi H.  Continuous positive airway pressure: evaluation of a novel therapy for patients with acute ischemic stroke..  Sleep.  2011 September 1. 34(9):1271-7.
[PubMed]

Hodges M, Best S, Richerson G.  Altered ventilatory and thermoregulatory control in male and female adult Pet-1 null mice..  Respiratory physiology & neurobiology.  2011 July 31. 177(2):133-40.
[PubMed]

Ray R, Corcoran A, Brust R, Kim J, Richerson G, Nattie E, Dymecki S.  Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition..  Science (New York, N.Y.).  2011 July 29. 333(6042):637-42.
[PubMed]

Richerson G, Buchanan G.  The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP..  Epilepsia.  2011 January 1. 52 Suppl 1:28-38.
[PubMed]

Hodges M, Richerson G.  Medullary serotonin neurons and their roles in central respiratory chemoreception..  Respiratory physiology & neurobiology.  2010 October 31. 173(3):256-63.
[PubMed]

Buchanan G, Richerson G.  Central serotonin neurons are required for arousal to CO2..  Proceedings of the National Academy of Sciences of the United States of America.  2010 September 14. 107(37):16354-9.
[PubMed]

Bravata D, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight H, Lo  A, Richerson G, Gorman M, Williams L, Brass L, Agostini J, Mohsenin V, Roux F, Yaggi H.  Auto-titrating continuous positive airway pressure for patients with acute transient ischemic attack: a randomized feasibility trial..  Stroke; a journal of cerebral circulation.  2010 July 1. 41(7):1464-70.
[PubMed]

Ransom C, Wu Y, Richerson G.  Postdepolarization potentiation of GABAA receptors: a novel mechanism regulating tonic conductance in hippocampal neurons..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2010 June 2. 30(22):7672-84.
[PubMed]

Hodges M, Richerson G.  The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation..  Journal of applied physiology (Bethesda, Md. : 1985).  2010 May 1. 108(5):1425-32.
[PubMed]

Richerson G.  Respiratory plasticity in sleep apnoea: should it be harnessed or restrained?.  The Journal of physiology.  2010 January 1. 588(Pt 1):3-4.
[PubMed]

Corcoran A, Hodges M, Wu Y, Wang W, Wylie C, Deneris E, Richerson G.  Medullary serotonin neurons and central CO2 chemoreception..  Respiratory physiology & neurobiology.  2009 August 31. 168(1-2):49-58.
[PubMed]

Hodges M, Wehner M, Aungst J, Smith J, Richerson G.  Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2009 August 19. 29(33):10341-9.
[PubMed]

Buchanan G, Richerson G.  Role of chemoreceptors in mediating dyspnea..  Respiratory physiology & neurobiology.  2009 May 30. 167(1):9-19.
[PubMed]

Ptak K, Yamanishi T, Aungst J, Milescu L, Zhang R, Richerson G, Smith J.  Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2009 March 25. 29(12):3720-37.
[PubMed]

Kinney H, Richerson G, Dymecki S, Darnall R, Nattie E.  The brainstem and serotonin in the sudden infant death syndrome..  Annual review of pathology.  2009 January 1. 4:517-50.
[PubMed]

Hodges M, Richerson G.  Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons..  Respiratory physiology & neurobiology.  2008 December 31. 164(3):350-7.
[PubMed]

Hodges M, Richerson G.  Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects..  Respiratory physiology & neurobiology.  2008 December 10. 164(1-2):222-32.
[PubMed]

Johnson S, Haxhiu M, Richerson G.  GFP-expressing locus ceruleus neurons from Prp57 transgenic mice exhibit CO2/H+ responses in primary cell culture..  Journal of applied physiology (Bethesda, Md. : 1985).  2008 October 1. 105(4):1301-11.
[PubMed]

Hodges M, Tattersall G, Harris M, McEvoy S, Richerson D, Deneris E, Johnson R, Chen Z, Richerson G.  Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2008 March 5. 28(10):2495-505.
[PubMed]

Wu Y, Wang W, Díez-Sampedro A, Richerson G.  Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1..  Neuron.  2007 December 6. 56(5):851-65.
[PubMed]

Wang W, Richerson G.  Changes in glucose do not alter baseline firing rate or chemosensitivity of serotonin neurons cultured from the medullary raphé..  Respiratory physiology & neurobiology.  2007 August 1. 157(2-3):235-41.
[PubMed]

Wu Y, Wang W, Richerson G.  The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters..  Journal of neurophysiology.  2006 November 1. 96(5):2425-36.
[PubMed]

Díez-Sampedro A, Silverman W, Bautista J, Richerson G.  Mechanism of increased open probability by a mutation of the BK channel..  Journal of neurophysiology.  2006 September 1. 96(3):1507-16.
[PubMed]

Du  W, Bautista J, Yang H, Diez-Sampedro A, You S, Wang L, Kotagal P, Lüders H, Shi J, Cui J, Richerson G, Wang Q.  Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder..  Nature genetics.  2005 July 1. 37(7):733-8.
[PubMed]

Richerson G, Wang W, Hodges M, Dohle C, Diez-Sampedro A.  Homing in on the specific phenotype(s) of central respiratory chemoreceptors..  Experimental physiology.  2005 May 1. 90(3):259-66; discussion 266-9.
[PubMed]

Richerson G.  Looking for GABA in all the wrong places: the relevance of extrasynaptic GABA(A) receptors to epilepsy..  Epilepsy currents / American Epilepsy Society.  2004 November 1. 4(6):239-42.
[PubMed]

Bouyer P, Bradley S, Zhao J, Wang W, Richerson G, Boron W.  Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphe or hippocampus..  The Journal of physiology.  2004 August 15. 559(Pt 1):85-101.
[PubMed]

Richerson G.  Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis..  Nature reviews. Neuroscience.  2004 June 1. 5(6):449-61.
[PubMed]

Nattie E, Li  A, Richerson G, Lappi D.  Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo..  The Journal of physiology.  2004 April 1. 556(Pt 1):235-53.
[PubMed]

Richerson G, Bekkers J.  Learning to take a deep breath--with BDNF..  Nature medicine.  2004 January 1. 10(1):25-6.
[PubMed]

Richerson G, Wu Y.  Role of the GABA transporter in epilepsy..  Advances in experimental medicine and biology.  2004 January 1. 548:76-91.
[PubMed]

Severson C, Wang W, Pieribone V, Dohle C, Richerson G.  Midbrain serotonergic neurons are central pH chemoreceptors..  Nature neuroscience.  2003 November 1. 6(11):1139-40.
[PubMed]

Richerson G, Wu Y.  Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore..  Journal of neurophysiology.  2003 September 1. 90(3):1363-74.
[PubMed]

Wu Y, Wang W, Richerson G.  Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release..  Journal of neurophysiology.  2003 April 1. 89(4):2021-34.
[PubMed]

Bradley S, Pieribone V, Wang W, Severson C, Jacobs R, Richerson G.  Chemosensitive serotonergic neurons are closely associated with large medullary arteries..  Nature neuroscience.  2002 May 1. 5(5):401-2.
[PubMed]

Wang W, Bradley S, Richerson G.  Quantification of the response of rat medullary raphe neurones to independent changes in pH(o) and P(CO2)..  The Journal of physiology.  2002 May 1. 540(Pt 3):951-70.
[PubMed]

Richerson G, Wang W, Tiwari J, Bradley S.  Chemosensitivity of serotonergic neurons in the rostral ventral medulla..  Respiration physiology.  2001 December 1. 129(1-2):175-89.
[PubMed]

Wang W, Tiwari J, Bradley S, Zaykin R, Richerson G.  Acidosis-stimulated neurons of the medullary raphe are serotonergic..  Journal of neurophysiology.  2001 May 1. 85(5):2224-35.
[PubMed]

Wu Y, Wang W, Richerson G.  GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2001 April 15. 21(8):2630-9.
[PubMed]

Wang W, Richerson G.  Chemosensitivity of non-respiratory rat CNS neurons in tissue culture..  Brain research.  2000 March 31. 860(1-2):119-29.
[PubMed]

Wang W, Richerson G.  Development of chemosensitivity of rat medullary raphe neurons..  Neuroscience.  1999 March 1. 90(3):1001-11.
[PubMed]

Wang W, Pizzonia J, Richerson G.  Chemosensitivity of rat medullary raphe neurones in primary tissue culture..  The Journal of physiology.  1998 September 1. 511 ( Pt 2):433-50.
[PubMed]

Gaspary H, Wang W, Richerson G.  Carrier-mediated GABA release activates GABA receptors on hippocampal neurons..  Journal of neurophysiology.  1998 July 1. 80(1):270-81.
[PubMed]

Richerson G.  Chloride: an anaplastic anion?.  Neuroreport.  1996 April 10. 7(5):969-70.
[PubMed]

Oyelese A, Eng D, Richerson G, Kocsis J.  Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons..  Journal of neurophysiology.  1995 August 1. 74(2):673-83.
[PubMed]

Honmou O, Kocsis J, Richerson G.  Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro..  Epilepsy research.  1995 March 1. 20(3):193-202.
[PubMed]

Richerson G.  Response to CO2 of neurons in the rostral ventral medulla in vitro..  Journal of neurophysiology.  1995 March 1. 73(3):933-44.
[PubMed]

Richerson G, Messer C.  Effect of composition of experimental solutions on neuronal survival during rat brain slicing..  Experimental neurology.  1995 January 1. 131(1):133-43.
[PubMed]

Richerson G, Getting P.  Medullary respiratory neurons in the guinea pig: localization and firing patterns..  Brain research.  1992 September 18. 591(1):79-87.
[PubMed]

Bekkers J, Richerson G, Stevens C.  Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices..  Proceedings of the National Academy of Sciences of the United States of America.  1990 July 1. 87(14):5359-62.
[PubMed]

Richerson G, Getting P.  Preservation of integrative function in a perfused guinea pig brain..  Brain research.  1990 May 28. 517(1-2):7-18.
[PubMed]

Richerson G, Getting P.  Maintenance of complex neural function during perfusion of the mammalian brain..  Brain research.  1987 April 14. 409(1):128-32.
[PubMed]

Dekin M, Richerson G, Getting P.  Thyrotropin-releasing hormone induces rhythmic bursting in neurons of the nucleus tractus solitarius..  Science (New York, N.Y.).  1985 July 5. 229(4708):67-9.
[PubMed]

Date Last Modified: 08/11/2015 - 17:10:12