Neurology

George B. Richerson, MD, PhD

Portrait

Specialty: Breathing Control Disorders
The Roy J. Carver Chair in Neuroscience
Director: Clinical Neuroscientist Training Program in Neurology
Head, Department of Neurology
Professor of Neurology
Professor of Molecular Physiology and Biophysics

Contact Information

Primary Office: 2151-A1 RCP
Iowa City, IA 52242
Primary Office Phone: 319-356-4296

Lab: 1000 ML
Iowa City, IA 52242

Email: george-richerson@uiowa.edu
Web: Richerson Laboratory

Education

BS, Aerospace Engineering, Iowa State University
MD, Medicine, University of Iowa
PhD, Molecular Physiology and Biophysics, University of Iowa

Internship, Waterbury Hospital Health Center
Residency, Neurology Chief Resident, Yale-New Haven Hospital

Licensure and Certifications

Physician's and Surgeon's License Connecticut Board of Health
Physician's and Surgeon's License Iowa Board of Medicine
Diplomate American Board of Psychiatry and Neurology

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Sudden death in epilepsy (SUDEP) and infants (SIDS), GABA mechanisms in epilepsy, Non-motor symptoms of Parkinson's disease, Control of breathing, Sleep, Serotonin, Brainstem mechanisms

All Publications

Corcoran A, Richerson G, Harris M.  Serotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ..  Respiratory physiology & neurobiology.  2013 February. 
[PubMed]

Hodges M, Best S, Richerson G.  Altered ventilatory and thermoregulatory control in male and female adult Pet-1 null mice..  Respiratory physiology & neurobiology.  2011 July. 177(2):133-40.
[PubMed]

Bravata D, Concato J, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight H, Lo A, Richerson G, Gorman M, Williams L, Brass L, Agostino J, Mohsenin V, Roux F, Yaggi H, Richerson G.  Continuous Positive Airway Pressure: Evaluation of a novel therapy for patients with acute ischemic stroke.  Sleep.  2011. 34(9):1271-1277.

Ray R, Corcoran A, Brust R, Kim J, Nattie E, Dymecki S, Richerson G.  Homeostatic imbalance upon acute in vivo serotonergic neuron inhibition.  Science.  2011. 333(6042):637-642.

Richerson G.  The role of the neurotransmitter serotonin in SUDEP.  Epilepsy Australia Ltd, Camberwell, Victoria.  2011. 

Buchanan G, Richerson G.  The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP.  Epilepsia.  2011. 52:28-28.

Richerson G.  Modulation of tonic GABA currents in cultured rat hippocampal neurons by connexin hemichannel blockers..  Winter Conf. Brain Res. Keystone, CO.  2011 January. 

Richerson G, Buchanan G.  The serotonin axis: Shared mechanisms in seizures, depression, and SUDEP..  Epilepsia.  2011 January. 52 Suppl 1:28-38.
[PubMed]

Buchanan G, Richerson G.  Central serotonin neurons are required for arousal to CO2..  Proceedings of the National Academy of Sciences of the United States of America.  2010 September. 107(37):16354-9.
[PubMed]

Ransom C, Wu Y, Richerson G.  Postdepolarization potentiation of GABAA receptors: a novel mechanism regulating tonic conductance in hippocampal neurons..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2010 June. 30(22):7672-84.
[PubMed]

Buchanan G, Richerson G.  Central serotonin neurons are required for arousal to CO2.  PNAS.  2010. 107(37):16354-9.

Richerson G.  Cholinergic mechanisms involved in chemosensitivity of cultured 5-HT neurons..  Soc. Neurosci. Abstr..  2010. 36.

Richerson G.  Development of chemosensitivity to CO2 and O2 in mice with absence of central serotonin neurons in vivo..  2010. 36.

Richerson G.  Identification of chemosensitive and insensitive serotonergic and GABAergic neurons in rat medullary raphé nuclei..  Soc. Neurosci. Abstr..  2010. 36.

Richerson G.  Mapping chemosensitivity onto genetically-defined serotonergic neuron subtypes..  Soc. Neurosci. Abstr..  2010. 36.

Richerson G.  Medullary serotonin neurons and their roles in central.  Respir Physiol Neurobiol.  2010. 173(3):256-263.

Richerson G.  Multiple mechanisms rapidly regulate tonic GABA currents in cultured rat hippocampal neurons..  Epilepsia.  2010. 

Richerson G.  Postdepolarization Potentiation of GABAA Receptors:.  J Neurosci.  2010. 30(22):7672-7684.

Richerson G.  Respiratory plasticity in sleep apnoea: Should it be harnessed or restrained?.  J Physiol.  2010. 588(1):3-4.

Richerson G.  Serotonergic raphe neurons are required for normal burst rate and chemosensitivity in medullary slices. .  Soc. Neurosci. Abstr..  2010. 36.

Richerson G.  The role of medullary serotonin (5-HT) neurons in respiratory.  J Appl Physiol.  2010. 108(5):1425-1432.

Richerson G.  Respiratory plasticity in sleep apnoea: should it be harnessed or restrained?.  The Journal of physiology.  2010 January. 588(Pt 1):4-Mar.
[PubMed]

Hodges M, Wehner M, Aungst J, Smith J, Richerson G.  Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2009 August. 29(33):10341-9.
[PubMed]

Richerson G.  Acidosis inhibits a calcium-activated non-selective cation current in mature serotonergic neurons. .  The 11th Oxford Conference on Modeling and Control of Breathing, Nara, Japan..  2009 July. 

Richerson G.  Chemosensitivity of mouse 5-HT neurons to hypercapnic acidosis is dependent upon age and temperature in brainstem slices in vitro..  Soc. Neurosci. Abstr..  2009. 35.

Richerson G.  Control of ventilation.  WB Saunders, Co, New York, NY..  2009. 

Richerson G.  Differentiating pre- vs. post- synaptic effects of 5-HT1a receptor activation on breathing..  Soc. Neurosci. Abstr..  2009. 35.

Richerson G.  Effect of genetic deletion of 5-HT neurons on sleep and arousal..  Soc. Neurosci. Abstr.  2009. 35.

Richerson G.  Hypercapnic acidosis inhibits a calcium-activated non-selective cation current in mature serotonergic neurons. .  Soc. Neurosci. Abstr..  2009. 35.

Richerson G.  Increased seizure susceptibility and post-ictal respiratory suppression in mice with genetic deletion of 5-HT neurons..  Epilepsia.  2009. 

Richerson G.  Medullary serotonin neurons and central CO2 chemoreception..  Respir Physiol Neurobiol.  2009. 168:49-58.

Richerson G.  Post-depolarization potentiation of GABAA receptors: a novel mechanism regulating tonic inhibition in hippocampal neurons..  Epilepsia.  2009. 

Richerson G.  Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P..  J Neurosci.  2009. 29(12):3720-37.

Richerson G.  Role of chemoreceptors in mediating dyspnea.  Respir Physiol Neurobiol.  2009. 167(1):9-19.

Richerson G.  The autonomic nervous system.  WB Saunders, Co, New York, NY..  2009. 

Richerson G.  The brainstem and serotonin in the sudden infant death syndrome..  Annual Rev Pathol.  2009. 4:517-550.

Richerson G.  Transgenic mice lacking.  J Neurosci.  2009. 29(33):10341-10349.

Hodges M, Richerson G.  Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects..  Respiratory physiology & neurobiology.  2008 December. 164(2-Jan):222-32.
[PubMed]

Richerson G.  Critical role of 5-HT neurons in control of breathing in neonatal mice in vivo and in vitro..  International Symposium on Respiratory Control. Saint Maximin en Provence, France..  2008 December. 

Hodges M, Richerson G.  Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons..  Respiratory physiology & neurobiology.  2008 December. 164(3):350-7.
[PubMed]

Hodges M, Tattersall G, Harris M, McEvoy S, Richerson D, Deneris E, Johnson R, Chen Z, Richerson G.  Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2008 March. 28(10):2495-505.
[PubMed]

Richerson G.  Carotid body dysfunction and altered oxygen homeostasis in models of Parkinson’s disease..  The FASEB Journal.  2008. 22(1231.5).

Richerson G.  Contribution of chemosensitive 5-HT neurons to interactions between the sleep/wake cycle and respiratory control..  Birkhauser Verlag AG, Basel, Switzerland.  2008. 

Richerson G.  Contributions of 5-HT neurons to respiratory control: Neuromodulatory and trophic effects.  Respir Physiol Neurobiol.  2008. 164:222-232.

Richerson G.  Defects in breathing and thermoregulation after genetic deletion of central serotonin neurons.  J Neurosci.  2008. 28(10):2495-2505.

Richerson G.  Expression of pH sensitive ion channels in CO2/H+ sensitive GFP+ locus coeruleus neurons of Prp57 transgenic mice..  Soc. Neurosci. Abstr..  2008. 34.

Richerson G.  GFP expressing Locus Coeruleus neurons from Prp57 transgenic mice exhibit differential CO2/H+ responses in primary cell culture..  J Appl Physiol.  2008. 105(4):1301-11.

Richerson G.  Interaction between defects in ventilatory and thermoregulatory control in mice with near-complete absence of 5-HT neurons. .  Respir Physiol Neurobiol.  2008. 164:350-357.

Richerson G.  Medullary raphe nuclei and respiratory control..  Springer-Verlag, Heidelberg, Germany..  2008. 

Richerson G.  Neonatal mice lacking central 5-HT neurons exhibit abnormal respiratory motor patterns in vitro..  Soc. Neurosci. Abstr..  2008. 34.

Richerson G.  Neonatal mice lacking central 5-HT neurons have severe apnea and a high mortality..  Soc. Neurosci. Abstr..  2008. 34.

Richerson G.  Prp57 transgenic mice express multiple pH sensitive ion channels in CO2/H+ sensitive GFP+ locus coeruleus neurons..  FASEB Abstr. .  2008. 21.

Richerson G.  Raphé neurons stimulate respiratory circuit activity by endogenously released serotonin and substance P. .  Soc. Neurosci. Abstr..  2008. 34.

Richerson G.  Serotonin (5-HT) facilitates ventilation via distinct 5HT2 and 5HT4 receptor-mediated mechanisms in situ, in the arterially perfused rat brainstem preparation..  FASEB Abstr..  2008. 21.

Richerson G.  Stimulation by hypercapnic acidosis in mouse 5-HT neurons in vitro is enhanced by age and increased temperature..  Soc. Neurosci. Abstr..  2008. 34.

Richerson G.  The prevalence of positional sleep apnea among patients with acute ischemic stroke and transient ischemic attacks..  Stroke.  2008. 39(2):616.

Richerson G.  Voltage-dependent properties of extrasynaptic GABAa receptors in cultured rat hippocampal neurons..  Soc. Neurosci. Abstr..  2008. 34.

Wu Y, Wang W, Díez-Sampedro A, Richerson G.  Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1..  Neuron.  2007 December. 56(5):851-65.
[PubMed]

Wang W, Richerson G.  Changes in glucose do not alter baseline firing rate or chemosensitivity of serotonin neurons cultured from the medullary raphé..  Respiratory physiology & neurobiology.  2007 August. 157(3-Feb):235-41.
[PubMed]

Richerson G.  Adult mice with genetic deletion of 5-HT neurons exhibit a severe loss of central chemoreception..  FASEB Abstr..  2007. 20.

Richerson G.  Changes in glucose do not alter baseline firing rate or chemosensitivity of serotonin neurons cultured from the medullary raphé..  Respir Physiol Neurobiol.  2007. 157(2-3):235-41.

Richerson G.  Deficiency in hypercapnia-induced arousal in mice with genetic deletion of 5-HT neurons..  Soc. Neurosci. Abstr..  2007. 33.

Richerson G.  Genetic deletion of 5-HT neurons leads to impaired brown adipose tissue (BAT) activation..  Soc. Neurosci. Abstr..  2007. 33.

Richerson G.  GFP expressing locus coeruleus neurons exhibit intrinsic CO2/H+ responses in primary cell culture..  Soc. Neurosci. Abstr..  2007. 33.

Richerson G.  GFP expressing locus coeruleus neurons from prp57 transgenic mice exhibit intrinsic CO2/H+ responses in primary cell culture..  FASEB Abstr..  2007. 20.

Richerson G.  Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1..  Neuron.  2007. 56(5):851-65.

Richerson G.  The role of serotonin (5-HT) and post-synaptic 5-HT receptor subtypes in the ventilatory response to hypercapnia in situ..  Soc. Neurosci. Abstr..  2007. 33.

Wu Y, Wang W, Richerson G.  The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters..  Journal of neurophysiology.  2006 November. 96(5):2425-36.
[PubMed]

Díez-Sampedro A, Silverman W, Bautista J, Richerson G.  Mechanism of increased open probability by a mutation of the BK channel..  Journal of neurophysiology.  2006 September. 96(3):1507-16.
[PubMed]

Richerson G.  A mutation in the BK channel leads to increased calcium sensitivity and epilepsy..  Biophysical Soc. Abstr..  2006. 

Richerson G.  Activation of 5HT1A receptors with 8-OH-DPAT does not prevent gasping but may impair autoresuscitation..  Soc. Neurosci. Abstr..  2006. 32.

Richerson G.  Adult mice with 5-HT neuron-specific knockout of Lmx1b exhibit an attenuated hypercapnic ventilatory response..  FASEB Abstr..  2006. 19.

Richerson G.  GAT1 is near equilibrium under normal physiological conditions and reverses easily in response to depolarization..  The GABAergic System. Cold Spring Harbor Laboratory, NY..  2006. 

Richerson G.  Genetic deletion of 5-HT neurons does not influence the hypoxic ventilatory response, baseline temperature or the response to mild hyper- or hypo-thermia, but blunts the hypercapnic ventilatory response and prevents thermoregulation in response to severe cold exposure..  Soc. Neurosci. Abstr..  2006. 32.

Richerson G.  Inhibiting serotonergic neurons abolishes hypercapnic ventilatory sensitivity in the unanesthetized in situ perfused rat brainstem preparation..  Soc. Neurosci. Abstr..  2006. 32.

Richerson G.  Mechanism of increased open probability by a mutation of the BK channel..  J Neurophysiol.  2006. 96:1507-1516.

Richerson G.  Modulation of neuronal activity in the pre-Botzinger complex by medullary raphe neurons.  Soc. Neurosci. Abstr..  2006. 32.

Richerson G.  Modulation of neuronal activity in the pre-Bötzinger complex by medullary raphe neurons..  Oxford Conference, Banff, Alberta..  2006. 

Richerson G.  Relationship between dendrites of serotonin neurons and large midline vessels of the medulla..  FASEB Abstr..  2006. 19.

Richerson G.  The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters.  J Neurophysiol.  2006. 96:2425-2436.

Richerson G, Wang W, Hodges M, Dohle C, Diez-Sampedro A.  Homing in on the specific phenotype(s) of central respiratory chemoreceptors..  Experimental physiology.  2005 May. 90(3):259-66; discussion 266-9.
[PubMed]

Richerson G.  Acidosis-inhibited raphé neurons are GABAergic..  FASEB Abstr..  2005. 19.

Richerson G.  Adult Pet-1 knockout mice exhibit an attenuated hypercapnic ventilatory response..  Soc. Neurosci. Abstr..  2005. 31.

Richerson G.  Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder..  Nature Genetics.  2005. 37(7):733-738.

Richerson G.  Commentary on “Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors.”.  Exp Physiol.  2005. 90(3):247-257.

Richerson G.  Homing in on the specific phenotype(s) of central respiratory chemoreceptors.  Exp Physiol.  2005. 90(3):259-269.

Richerson G.  Lack of smooth muscle in arteries next to serotonergic neurons: Reduction of the diffusion barrier for CO2 in areas of central chemoreceptors..  FASEB Abstr..  2005. 19.

Richerson G.  Modulation of neuronal activity in the pre-Bötzinger complex by medullary raphe neurons..  Soc. Neurosci. Abstr..  2005. 31.

Richerson G.  Putative central chemoreceptors of the medullary raphé are not responsive to changes in glucose..  Soc. Neurosci. Abstr..  2005. 31.

Richerson G.  Tonic inhibition in hippocampal cultures is due to GABA release via two distinct nonvesicular mechanisms..  Soc. Neurosci. Abstr..  2005. 31.

Bouyer P, Bradley S, Zhao J, Wang W, Richerson G, Boron W.  Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphe or hippocampus..  The Journal of physiology.  2004 August. 559(Pt 1):85-101.
[PubMed]

Richerson G.  Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis..  Nature reviews. Neuroscience.  2004 June. 5(6):449-61.
[PubMed]

Richerson G.  Effect of extracellular acid-base disturbances on the intracellular pH of neurons cultured from rat.  J Physiol (Lond).  2004. 559:85-101.

Richerson G.  Learning to take a deep breath – with BDNF.  Nature Medicine.  2004. 10(1):25-26.

Richerson G.  Looking for GABA in all the wrong places: The relevance of extrasynaptic GABAA receptors to epilepsy.  Epilepsy Currents.  2004. 4(6):239-242.

Richerson G.  Medullary raphe neurons and serotonergic modulation of neuronal activity in the pre-Bötzinger complex..  Soc. Neurosci. Abstr..  2004. 30.

Richerson G.  Medullary serotonergic neurons and adjacent neurons that express neurokinin-1 receptors are both involved in chemoreception in vivo..  J Physiol (Lond).  2004. 556(1):235-253.

Richerson G.  Role of the GABA transporter in epilepsy..  Adv Exp Med Biol.  2004. 548:76-91.

Richerson G, Wu Y.  Role of the GABA transporter in epilepsy..  Advances in experimental medicine and biology.  2004. 548:76-91.
[PubMed]

Richerson G.  Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis..  Nature Reviews Neuroscience.  2004. 5:449-461.

Richerson G.  Use of multielectrode arrays in recording from cultured chemosensitive medullary raphe neurons..  FASEB Abstr..  2004. 18.

Severson C, Wang W, Pieribone V, Dohle C, Richerson G.  Midbrain serotonergic neurons are central pH chemoreceptors..  Nature neuroscience.  2003 November. 6(11):1139-40.
[PubMed]

Richerson G, Wu Y.  Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore..  Journal of neurophysiology.  2003 September. 90(3):1363-74.
[PubMed]

Richerson G.  Role of serotonergic neurons in SIDS..  Neurochemistry Winter Conference, Sölden, Austria..  2003 April. 

Wu Y, Wang W, Richerson G.  Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release..  Journal of neurophysiology.  2003 April. 89(4):2021-34.
[PubMed]

Richerson G.  Respiratory chemoreception in mammalian respiratory networks..  International Congress of Comparative Physiology and Biochemistry. La Trobe, Australia..  2003 February. 

Richerson G.  Control of Brain pH by the Serotonergic System: Changes in Early Postnatal Development.  Soc. Neurosci. Abstr..  2003. 29.

Richerson G.  Midbrain serotonergic neurons are central pH chemoreceptors.  Nature Neurosci.  2003. 6(11):1139-1140.

Richerson G.  Nonvesicular neurotransmission can occur between hippocampal neurons via reversal of the GABA transporter..  Soc. Neurosci. Abstr..  2003. 29.

Richerson G.  The dynamic equilibrium of neurotransmitter transporters: Not just for reuptake anymore.  J Neurophysiol.  2003. 90:1363-1374.

Richerson G.  Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release..  J Neurophysiol.  2003. 89(4):2021-2034.

Bradley S, Pieribone V, Wang W, Severson C, Jacobs R, Richerson G.  Chemosensitive serotonergic neurons are closely associated with large medullary arteries..  Nature neuroscience.  2002 May. 5(5):401-2.
[PubMed]

Wang W, Bradley S, Richerson G.  Quantification of the response of rat medullary raphe neurones to independent changes in pH(o) and P(CO2)..  The Journal of physiology.  2002 May. 540(Pt 3):951-70.
[PubMed]

Richerson G.  Characterization of a pH sensitive calcium-activated cation current in serotonergic medullary neurons..  Soc. Neurosci. Abstr..  2002. 28.

Richerson G.  Chemosensitive serotonergic neurons are intimately associated with large arteries of the ventral medulla.  Nature Neurosci.  2002. 5(5):401-402.

Richerson G.  Control of ventilation.  WB Saunders, Co, New York, NY.  2002. 

Richerson G.  Quantification of the response of rat medullary raphe neurones to independent changes in pHo and PCO2..  J Physiol (Lond).  2002. 540(3):951-970.

Richerson G.  Serotonergic modulation of ventilatory pattern in the perfused rat brainstem..  Soc. Neurosci. Abstr..  2002. 28.

Richerson G.  Serotonergic neurons from the rat midbrain are chemosensitive in slices and in culture..  Soc. Neurosci. Abstr..  2002. 28.

Richerson G.  Serotonergic neurons of the midbrain raphe are stimulated by acidosis and are closely associated with arteries..  Soc. Neurosci. Abstr..  2002. 28.

Richerson G.  Specific killing of rat medullary raphe 5-HT neurons by a serotonin transporter antibody-saporin conjugate reduces the ventilatory response to increased CO2 during sleep and wakefulness..  Soc. Neurosci. Abstr..  2002. 28.

Richerson G.  The autonomic nervous system.  WB Saunders, Co, New York, NY..  2002. 

Richerson G.  The sudden infant death syndrome, sleep and breathing..  FASEB Abstr..  2002. 16.

Richerson G.  Vigabatrin enhances tonic GABAergic inhibition mediated by carrier-mediated GABA release, without affecting vesicular GABA release..  Soc. Neurosci. Abstr..  2002. 28.

Richerson G, Wang W, Tiwari J, Bradley S.  Chemosensitivity of serotonergic neurons in the rostral ventral medulla..  Respiration physiology.  2001 December. 129(2-Jan):175-89.
[PubMed]

Richerson G.  Cellular mechanisms of chemosensitivity in serotonergic raphe neurons..  Neural control of breathing. Rotorua, New Zealand..  2001 September. 

Wang W, Tiwari J, Bradley S, Zaykin R, Richerson G.  Acidosis-stimulated neurons of the medullary raphe are serotonergic..  Journal of neurophysiology.  2001 May. 85(5):2224-35.
[PubMed]

Wu Y, Wang W, Richerson G.  GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2001 April. 21(8):2630-9.
[PubMed]

Richerson G.  Acidosis-stimulated neurons of the medullary raphe are serotonergic..  J Neurophysiol.  2001. 85:2224-2235.

Richerson G.  Chemosensitivity of serotonergic neurons in the rostral ventral medulla..  Respir Physiol.  2001. 129:175-189.

Richerson G.  Distribution of Na/HCO3 cotransporters in rat brain with subtype-specific antibodies..  Soc. Neurosci. Abstr..  2001. 27.

Richerson G.  GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter..  J Neurosci.  2001. 21(8):2630-2639.

Richerson G.  Inhibition of GABA transaminase induces activation of synaptic GABAA receptors due to nonvesicular GABA release..  Soc. Neurosci. Abstr..  2001. 27.

Richerson G.  Intracellular pH (pHi) response of medullary raphe neurons during extracellular acid-base perturbations..  Soc. Neurosci. Abstr..  2001. 27.

Richerson G.  Localization of the Na+-driven Cl/HCO3 exchanger protein (NDCBE1) in rat brain..  Soc. Neurosci. Abstr..  2001. 27.

Richerson G.  Mathematical modeling ofserotonergic rat medullary raphe neurons exhibiting a novel pH-regulated Ca2+-activated cation current..  Soc. Neurosci. Abstr..  2001. 27.

Richerson G.  Quantification of the response of serotonergic neurons to independent changes in pHo and PCO2..  Soc. Neurosci. Abstr..  2001. 27.

Richerson G.  Serotonergic neurons that project to the phrenic nuclei are located near large arteries on the ventral surface of the medulla..  Soc. Neurosci. Abstr..  2001. 27.

Richerson G.  The raphe and breathing: What is the connection?.  Winter Conf. Brain Res. Steamboat Springs, CO.  2001 January. 

Richerson G.  The response to CO2 and O2: From ion channels to networks..  Winter Conf. Brain Res. Steamboat Springs, CO.  2001 January. 

Richerson G.  Serotonergic neurons of the medullary raphe possess a novel pH sensitive calcium-dependent cation current..  Central Chemosensitivity 2000, Bochum, Germany..  2000 August. 

Wang W, Richerson G.  Chemosensitivity of non-respiratory rat CNS neurons in tissue culture..  Brain research.  2000 March. 860(2-Jan):119-29.
[PubMed]

Richerson G.  A novel pH sensitive cation current is present in putative central chemoreceptors of the medullary raphe..  Soc. Neurosci. Abstr..  2000. 26.

Richerson G.  Acidosis-stimulated neurons of the medullary raphe are closely associated with basilar penetrating arteries..  Soc. Neurosci. Abstr..  2000. 26.

Richerson G.  Chemosensitivity of nonrespiratory rat neurons in primary tissue culture..  Brain Research.  2000. 860:119-129.

Richerson G.  Chemosensitivity of serotonergic CNS neurons is enhanced by muscarinic receptor activation..  FASEB Abstr..  2000. 

Richerson G.  Muscarinic receptor activation enhances chemosensitivity of medullary raphe neurons..  Soc. Neurosci. Abstr..  2000. 26.

Richerson G.  Neurons of the medullary raphe have a uniform pHi response to CO2..  Soc. Neurosci. Abstr..  2000. 26.

Richerson G.  Rat hippocampal neurons can inhibit each other via reversal of the GABA transporter..  Soc. Neurosci. Abstr..  2000. 26.

Richerson G.  Refractory seizures in a 17-year-old: Re-evaluating therapy..  NeuroNetwork.  2000. 2(1):2-3.

Richerson G.  Vigabatrin induces an increase in GABA release due to reversal of the GABA transporter..  Epilepsia.  2000. 

Richerson G.  The medullary raphe and respiration: Such an obvious role, but what exactly is it?.  FASEB Special Topic. Washington, DC.  1999 April. 

Wang W, Richerson G.  Development of chemosensitivity of rat medullary raphe neurons..  Neuroscience.  1999 March. 90(3):1001-11.
[PubMed]

Richerson G.  Development of chemosensitivity of rat medullary raphe neurons..  Neurosci.  1999. 90(3):1001-1011.

Richerson G.  Neurons cultured from the region of the midbrain raphe are chemosensitive to acidosis..  Soc. Neurosci. Abstr..  1999. 25(71.10).

Richerson G.  Non-vesicular GABA release is enhanced by anticonvulsants that increase brain [GABA]..  Soc. Neurosci. Abstr..  1999. 

Richerson G.  Vigabatrin & gabapentin enhance carrier-mediated GABA release..  Epilepsia.  1999. 

Richerson G.  Heavy breathing in Snowmass: The role of serotonin in the response to high altitude..  Winter Conf. Brain Res. Session Chair. Snowmass, CO.  1999 January. 

Wang W, Pizzonia J, Richerson G.  Chemosensitivity of rat medullary raphe neurones in primary tissue culture..  The Journal of physiology.  1998 September. 511 ( Pt 2):433-50.
[PubMed]

Richerson G.  Carrier-mediated GABA release induces GABA receptor conductances in hippocampal neurons..  J Neurophysiol.  1998. 80:270-281.

Richerson G.  Chemosensitivity of medullary raphe neurons increases postnatally..  Soc. Neurosci. Abstr..  1998. 

Richerson G.  Chemosensitivity of rat medullary raphe neurones in primary tissue culture..  J Physiol (Lond).  1998. 511(2):433-450.

Richerson G.  Medullary raphe neurons stimulated by acidosis are serotonergic. .  Soc. Neurosci. Abstr..  1998. 

Richerson G.  pH effects on respiratory neurons..  John Wiley & Sons, New York, NY..  1998. 

Richerson G.  Quantification of the degree of chemosensitivity of medullary raphe neurons in tissue culture..  FASEB Abstr..  1998. 

Richerson G.  Carrier-mediated GABA release: Is there a functional role?.  Neuroscientist.  1997. 3(3):151-157.

Richerson G.  Effect of isocapnic acidosis and isohydric hypercapnea on firing rate and pHi of chemosensitive medullary neurons..  Soc. Neurosci. Abstr..  1997. 27(171.14).

Richerson G.  Is the function of the GABA transporters altered in epilepsy?.  American Epilepsy Society Annual Meeting.  1997. 

Richerson G.  Neurotransmitter expression in cocultures prepared from rat medullary raphe..  Soc. Neurosci. Abstr..  1997. 

Richerson G.  Sudden Infant Death: The role of central chemosensitivity..  Neuroscientist.  1997. 3(1):309-313.

Richerson G.  Ventromedial medullary neurons have a high degree of intrinsic chemosensitivity..  Soc. Neurosci. Abstr..  1997. 

Richerson G.  Chloride: an anaplastic anion?.  Neuroreport.  1996 April. 7(5):969-70.
[PubMed]

Richerson G.  Carrier-mediated GABA release induced by high [K+]o and low [Na+]o increases whole cell conductance in hippocampal neurons..  Soc. Neurosci. Abstr..  1996. 

Richerson G.  Chloride: An anaplastic anion?.  Neuroreport.  1996. 7:969-970.

Richerson G.  Effect of respiratory acid-base changes on intracellular pH of ventromedial medullary neurons..  pHysiology of Acid-Base Regulation: From Molecules to Humans, APS Conference, Snowmass, CO.  1996. 

Richerson G.  Mechanisms of rat ventromedial medullary neurons sensitive to acidosis.  Soc. Neurosci. Abstr..  1996. 

Richerson G.  New insights into a novel antiepileptic and neuroprotective mechanism..  Winter Conf. Brain Res..  1996. 29(51).

Richerson G.  Properties of cultured rat ventromedial medullary neurons sensitive to acidosis..  Neural Control of Breathing: Molecular to Organismal Perspectives, APS Conference, Madison, WI.  1996. 

Richerson G.  Rat ventromedial medullary neurons sensitive to acidosis are bulbospinal..  Soc. Neurosci. Abstr..  1996. 

Richerson G.  Role of carrier-mediated GABA release in seizures. .  Epilepsia.  1996. 

Oyelese A, Eng D, Richerson G, Kocsis J.  Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons..  Journal of neurophysiology.  1995 August. 74(2):673-83.
[PubMed]

Honmou O, Kocsis J, Richerson G.  Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro..  Epilepsy research.  1995 March. 20(3):193-202.
[PubMed]

Richerson G.  Response to CO2 of neurons in the rostral ventral medulla in vitro..  Journal of neurophysiology.  1995 March. 73(3):933-44.
[PubMed]

Richerson G.  Effect of composition of experimental solutions on neuronal survival during rat brain slicing..  Exp Neurol.  1995. 131:133-143.

Richerson G.  Electrophysiological response of CO2 sensitive cells in the ventral medulla. Central CO2 chemoreceptors: Where are they? How do they work?.  Am. J. Resp. Crit. Care Med..  1995. 151(4):D7.

Richerson G.  Electrophysiology of medullary raphe neurons in slices and tissue culture..  Soc. Neurosci. Abstr..  1995. 21.

Richerson G.  Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro..  Epi Res.  1995. 20:193-202.

Richerson G.  Nerve injury enhances GABAA receptor mediated conductances in a subclass of sensory neurons..  J Neurophysiol.  1995. 74(2):673-683.

Richerson G.  Response to CO2 of neurons in the rostral ventral medulla in vitro..  J Neurophysiol.  1995. 73(3):933-944.

Richerson G, Messer C.  Effect of composition of experimental solutions on neuronal survival during rat brain slicing..  Experimental neurology.  1995 January. 131(1):133-43.
[PubMed]

Richerson G.  CO2 modulates pacemaker neurons in the medullary raphe and parapyramidal region of the rat in vitro..  Soc. Neurosci. Abstr..  1993. 19.

Richerson G.  GABA: Functions beyond inhibition..  Winter Conf. Brain Res..  1993. 26(34).

Richerson G.  GABAA-induced conductance and cell size distribution of rat dorsal root ganglion neurons following nerve ligation..  Soc. Neurosci. Abstr..  1993. 19.

Richerson G, Getting P.  Medullary respiratory neurons in the guinea pig: localization and firing patterns..  Brain research.  1992 September. 591(1):79-87.
[PubMed]

Richerson G.  Chronic nerve ligation leads to enhanced GABAA receptor-induced conductances in a subclass of rat dorsal root ganglion neurons..  Soc. Neurosci. Abstr..  1992. 18.

Richerson G.  Electrophysiologic effects of changes in PCO2 on rat medullary neurons in vitro.  Soc. Neurosci. Abstr..  1992. 18.

Richerson G.  Medullary respiratory neurons in the guinea pig. Localization and firing patterns..  Brain Res;  1992. 

Richerson G.  Perfused brain preparations in neurobiology..  Winter Conf. Brain Res..  1991. 24(31).

Richerson G, Getting P.  Preservation of integrative function in a perfused guinea pig brain..  Brain research.  1990 May. 517(2-Jan):18-Jul.
[PubMed]

Richerson G.  Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices..  PNAS.  1990. 87:5359-5362.

Richerson G.  Preservation of integrative function in a perfused guinea pig brain..  Brain Res.  1990. 517:7-18.

Richerson G.  Biophysical properties of bulbospinal neurons in the ventral part of the nucleus tractus solitarius in guinea pigs..  Alan R. Liss, New York, NY..  1987. 

Richerson G.  Maintenance of complex neural function during perfusion of the mammalian brain. .  Brain Res.  1987. 409:128-132.

Richerson G.  The respiratory centers of the guinea pig: In vivo and perfused brain studies..  1987. 

Richerson G.  Maintenance of complex circuit function during perfusion of the mammalian brain..  Soc. Neurosci. Abstr..  1986. 12.

Richerson G.  Viability of the respiratory system in a perfused brain: A model for studying neural function..  Clinical Research.  1986. 34(3):1005A.

Richerson G.  Characterization of NTS neurons in brain stem slices from the guinea pig.  MTP press, Lancaster, England..  1985. 

Richerson G.  Thyrotropin-releasing hormone induces rhythmic bursting in neurons of the nucleus tractus solitarius..  Science.  1985. 229:67-69.

Richerson G.  Medullary respiratory neurons of the guinea pig..  Fed. Proc. .  1984. 43(3):320.

Richerson G.  Respiratory activity in a perfused guinea pig brain spinal cord preparation..  Soc. Neurosci. Abstr..  1984. 10.

Richerson G.  Thyrotropin-releasing hormone induces spontaneous bursting in neurons of the nucleus tractus solitarius..  Soc. Neurosci. Abstr..  1984. 10.

Richerson G.  Characteristics of respiratory neurons in the guinea pig..  Soc. Neurosci. Abstr..  1983. 9.

Richerson G.  5-HT neurons and central CO2 chemoreception.  Elsevier, Amsterdam. 

Richerson G.  Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Ischemic Stroke.  Stroke.  41(7):1464-1470.

Richerson G.  Brainstem modulation of brain function. 

Richerson G.  Disorders of ventilatory control in adult neurological and psychiatric disease..  American Physiological Society, Bethesda, MD.. 

Richerson G.  GABA transporters: Regulation of tonic inhibition.  Elsevier, Oxford, UK.. 

Richerson G.  GABA transporters: Target of anticonvulsants.  Elsevier, Oxford, UK.. 

Richerson G.  Looking for GABA in all the wrong places: the relevance of extrasynaptic GABA(A) receptors to epilepsy..  Epilepsy currents / American Epilepsy Society.  4(6):239-42.
[PubMed]

Richerson G.  The brainstem and cranial nerves. 

Date Last Modified: 06/07/2014 - 21:56:23