Neurology

Enrique Leira, MD, MS

Portrait

Specialty: Stroke
Associate Professor of Neurology

Contact Information

Primary Office: 2147 RCP
Iowa City, IA 52242
Primary Office Phone: 319-356-8755

Email: enrique-leira@uiowa.edu

Education

MD, Universidad de Santiago de Compostela, Galicia (Spain)
MS, Epidemiology, University of Iowa, Iowa City, IA

Fellowship, Cerebrovascular Diseases, University of Iowa, Iowa City, IA
Residency, St. Louis University, St. Louis, MO

Research Summary

Enrique Leira MD MS is an Assistant Professor in Neurology in the College of Medicine at the University of Iowa with a specialization in Cerebrovascular Diseases and Epidemiology. His research focus is acute stroke management, including evidence-based strategies to improve and accelerate stroke treatment in rural areas. There is an unnaceptable disparity in acute stroke practices between urban tertiary centers and those 25% patients living in rural areas. The gap will be further increased as rural patients continue to be excluded from time-dependent stroke trials due to distance/time from research centers. His research interests include novel strategies to enable participation of patients living in rural areas in acute trials testing stroke therapies, such as randomization before arrival to the University while they are being transported in a helicopter ambulance. Dr. Leira is also interested in designing novel forms of integrated physiological monitoring for stroke patients in order to modernize the current practice of performing gross "neurochecks" by nurses. The goal is to improve the beneficial effect of dedicated stroke units by detecting neurological deterioration in an objective, real time manner, without having to wake up the patient every few hours. He is a member of the Operator Performance laboratory in the College of Engineering. http://www.ccad.uiowa.edu/opl/. He also has an interest in aviation neurology, neurological emergencies in flight and developing real-time telecommunication solutions for the helicopter ambulances that transport stroke patients from small rural hospitals to large tertiary care centers.

All Publications

Leira E, Kaskie B, Froehler M, Adams H.  The Growing Shortage of Vascular Neurologists in The Era of Health Reform: Planning is Brain!.  Stroke; a journal of cerebral circulation.  2013 March. 44(3):822-7.
[PubMed]

Leira E, Fairchild G, Segre A, Rushton G, Froehler M, Polgreen P.  Primary stroke centers should be located using maximal coverage models for optimal access..  Stroke; a journal of cerebral circulation.  2012 September. 43(9):2417-22.
[PubMed]

Leira E, Kaldjian L, Ludwig B, Torner J, Olalde H, Hacke W, Adams H.  Lack of international consensus on ethical aspects of acute stroke trials..  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.  2012 April. 21(3):200-4.
[PubMed]

Leira E, Ludwig B, Gurol M, Torner J, Adams H.  The types of neurological deficits might not justify withholding treatment in patients with low total National Institutes of Health Stroke Scale scores..  Stroke; a journal of cerebral circulation.  2012 March. 43(3):782-6.
[PubMed]

Mikami K, Jorge R, Adams H, Davis P, Leira E, Jang M, Robinson R.  Effect of antidepressants on the course of disability following stroke..  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.  2011 December. 19(12):1007-15.
[PubMed]

Cruz-Flores S, Rabinstein A, Biller J, Elkind M, Griffith P, Gorelick P, Howard G, Leira E, Morgenstern L, Ovbiagele B, Peterson E, Rosamond W, Trimble B, Valderrama A.  Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association/American Stroke Association..  Stroke; a journal of cerebral circulation.  2011 July. 42(7):2091-116.
[PubMed]

Day J, Policeni B, Smoker W, Dobre M, Zhang Y, Leira E, Davis P, Chen S, Olalde H, Adams H.  Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attack..  Stroke; a journal of cerebral circulation.  2011 February. 42(2):354-8.
[PubMed]

Kim J, Leira E, Callison R, Ludwig B, Moritani T, Magnotta V, Madsen M.  Toward fully automated processing of dynamic susceptibility contrast perfusion MRI for acute ischemic cerebral stroke..  Computer methods and programs in biomedicine.  2010 May. 98(2):204-13.
[PubMed]

Leira E, Ahmed A, Lamb D, Olalde H, Callison R, Torner J, Adams H.  Extending acute trials to remote populations: a pilot study during interhospital helicopter transfer..  Stroke; a journal of cerebral circulation.  2009 March. 40(3):895-901.
[PubMed]

Leira E, Ahmed A.  Development of an emergency department response to acute stroke ("Code Stroke")..  Current neurology and neuroscience reports.  2009 January. 9(1):35-40.
[PubMed]

Adams H, Leira E, Torner J, Barnathan E, Padgett L, Effron M, Hacke W.  Treating patients with 'wake-up' stroke: the experience of the AbESTT-II trial..  Stroke; a journal of cerebral circulation.  2008 December. 39(12):3277-82.
[PubMed]

Callison R, Leira E.  Strategies to improve acute stroke care of patients in rural and other geographically dispersed areas..  Current treatment options in neurology.  2008 November. 10(6):450-4.
[PubMed]

Leira E, Hess D, Torner J, Adams H.  Rural-urban differences in acute stroke management practices: a modifiable disparity..  Archives of neurology.  2008 July. 65(7):887-91.
[PubMed]

Leira E, Granner M, Torner J, Callison R, Adams H.  Education Research: The challenge of incorporating formal research methodology training in a neurology residency..  Neurology.  2008 May. 70(20):e79-84.
[PubMed]

Leira E, Adams H, Rosenthal G, Torner J.  Baseline NIH stroke scale responses estimate the probability of each particular stroke subtype..  Cerebrovascular diseases (Basel, Switzerland).  2008. 26(6):573-7.
[PubMed]

Leira E, Davis P, Martin C, Torner J, Yoo B, Weeks J, Hindman B, Todd M.  Improving prediction of outcome in "good grade" subarachnoid hemorrhage..  Neurosurgery.  2007 September. 61(3):470-3; discussion 473-4.
[PubMed]

Swenson A, Leira E.  Paroxysmal sneezing at the onset of lateral medullary syndrome: cause or consequence?.  European journal of neurology : the official journal of the European Federation of Neurological Societies.  2007 April. 14(4):461-3.
[PubMed]

Leira E, Pary J, Davis P, Grimsman K, Adams H.  Slow progressive acceptance of intravenous thrombolysis for patients with stroke by rural primary care physicians..  Archives of neurology.  2007 April. 64(4):518-21.
[PubMed]

Leira E, Lamb D, Nugent A, Ahmed A, Grimsman K, Clarke W, Adams H.  Feasibility of acute clinical trials during aerial interhospital transfer..  Stroke; a journal of cerebral circulation.  2006 October. 37(10):2504-7.
[PubMed]

Leira E, Condoor S, Germani M, Vogler G.  A novel, simple pressure safety valve for lumbar puncture..  Neurocritical care.  2005. 3(1):68-70.
[PubMed]

Leira E, Acharya A, Cruz-Flores S, Albaker O, Rao V, Abdulrauf S.  Blood pressure surge precedes intracerebral hemorrhage..  Neurocritical care.  2005. 2(1):43-5.
[PubMed]

Cruz-Flores S, Diamond A, Leira E.  Cerebral air embolism secondary to intra-aortic balloon pump rupture..  Neurocritical care.  2005. 2(1):49-50.
[PubMed]

Leira E, Cruz-Flores S, Wyrwich K, Northam G, Acharya A, Pan Y, Holzemer E, Womack S.  Improving pilot response to in-flight strokes: a randomized controlled trial..  Cerebrovascular diseases (Basel, Switzerland).  2005. 19(5):317-22.
[PubMed]

Cruz-Flores S, de Assis Aquino Gondim F , Leira E.  Brainstem involvement in hypertensive encephalopathy: clinical and radiological findings..  Neurology.  2004 April. 62(8):1417-9.
[PubMed]

Leira E, Bertrand M, Hogan R, Cruz-Flores S, Wyrwich K, Albaker O, Holzemer E.  Continuous or emergent EEG: can bedside caregivers recognize epileptiform discharges?.  Intensive care medicine.  2004 February. 30(2):207-12.
[PubMed]

Leira E, Chang K, Davis P, Clarke W, Woolson R, Hansen M, Adams H.  Can we predict early recurrence in acute stroke?.  Cerebrovascular diseases (Basel, Switzerland).  2004. 18(2):139-44.
[PubMed]

Johnston S, Leira E, Hansen M, Adams H.  Early recovery after cerebral ischemia risk of subsequent neurological deterioration..  Annals of neurology.  2003 October. 54(4):439-44.
[PubMed]

Gondim F, Leira E, Bertrand M.  Video electroencephalogram monitoring during paroxysmal upside down reversal of vision..  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.  2003 June. 23(2):180.
[PubMed]

Kaiboriboon K, Oliveira G, Leira E.  Apraxia of eyelid opening secondary to a dominant hemispheric infarction..  Journal of neurology.  2002 March. 249(3):341-2.
[PubMed]

Leira E, Cruz-Flores S, Leacock R, Abdulrauf S.  Sumatriptan can alleviate headaches due to carotid artery dissection..  Headache.  2001 June. 41(6):590-1.
[PubMed]

Selhorst J, Kulkantrakorn K, Corbett J, Leira E, Chung S.  Retinol-binding protein in idiopathic intracranial hypertension (IIH)..  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.  2000 December. 20(4):250-2.
[PubMed]

Leira E, Adams H.  Management of acute ischemic stroke..  Clinics in geriatric medicine.  1999 November. 15(4):701-20.
[PubMed]

Adams H, Bendixen B, Leira E, Chang K, Davis P, Woolson R, Clarke W, Hansen M.  Antithrombotic treatment of ischemic stroke among patients with occlusion or severe stenosis of the internal carotid artery: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)..  Neurology.  1999 July. 53(1):122-5.
[PubMed]

Adams H, Davis P, Leira E, Chang K, Bendixen B, Clarke W, Woolson R, Hansen M.  Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)..  Neurology.  1999 July. 53(1):126-31.
[PubMed]

Adams H, Leira E.  Treatment of acute ischemic stroke..  Drugs of today (Barcelona, Spain : 1998).  1998 July. 34(7):655-60.
[PubMed]

Leira E, Bendixen B, Kardon R, Adams H.  Brief, transient Horner's syndrome can be the hallmark of a carotid artery dissection..  Neurology.  1998 January. 50(1):289-90.
[PubMed]

Torner J, Davis P, Leira E.  Epidemiology of stroke in requiring intensive care..  New horizons (Baltimore, Md.).  1997 November. 5(4):422-32.
[PubMed]

Leira E, Ajax T, Adams H.  Limb-shaking carotid transient ischemic attacks successfully treated with modification of the antihypertensive regimen..  Archives of neurology.  1997 July. 54(7):904-5.
[PubMed]

Adams H, Leira E.  Brain attack. Acute therapeutic intervention. Antithrombotic and antiplatelet-aggregating drugs..  Neurosurgery clinics of North America.  1997 April. 8(2):207-17.
[PubMed]

Leira E.  Treatment of acute stroke.  Revista de neurologia.  36(1):86-92.
[PubMed]

Leira E, Cruz-Flores S, Acharya A, Pan Y.  Treatment with tissue plasminogen activator is not associated with increased use of neurosurgery..  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.  14(6):278-80.
[PubMed]

Date Last Modified: 06/07/2014 - 21:56:23