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Professor of Internal Medicine
- Infectious DiseasesProfessor of MicrobiologyProfessor of
Office: SW34-Q GHIowa City, IA 52242
Office Phone: 319-356-3169
Lab: 400 EMRBIowa City, IA 52242
BA, Carleton College, Northfield, MNMD, University of Rochester School of Medicine and Dentistry, Rochester, New York
Internship, Internal Medicine, University of Michigan, Ann Arbor, MIResidency, Internal Medicine, University of Michigan, Ann Arbor, MITropical Medicine Course, Tropical Medicine, Walter Reed Army Institute of Research, Washington, DCFellowship, Infectious Diseases, Department of Internal Medicine, University of Virginia, Charlottesville, VA
Medicine, Iowa Board of MedicineCertification in Tropical Medicine and Travelers’ Health, American Society of Tropical Medicine and HygieneInfectious Diseases, American Board of Internal MedicineInternal Medicine, American Board of Internal Medicine
Biosciences Graduate ProgramDepartment of Microbiology Graduate ProgramInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in ImmunologyInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Dr. Wilson's research studies address the molecular, cellular and immunobiology of infection with the Leishmania species protozoa. Human infection with these parasites leads to a wide spectrum of clinical syndromes. Both human immunogenetic and parasite-encoded virulence factors lead to divergent disease manifestations. Dr. Wilson’s studies focus on the contributions of both host and parasite molecular characteristics that determine the outcome of leishmaniasis.
Leishmania are spread through the bite of a sand fly vector, and reside intracellularly in macrophages in human or other mammalian hosts. The parasite causes dramatic changes in gene expression in the host phagocyte, and lab members are investigating host mRNAs, host microRNAs and the parasite encoded virulence molecules underlying these changes. Other projects utilize both murine models and cultured human cells to address the contributions of macrophages, monocyte subsets, neutrophils, dendritic cells and keratinocytes to the local immune responses. The group hypothesizes that Leishmania manipulate the local immune response through the release of exosomes containing virulence-related proteins into the host environment. Techniques of protein chemistry, mass spectrometry, confocal microscopy, gene knockout/transgenic parasites and in vivo imaging of luminescent or fluorescent parasites are used to address these goals.
Dr. Wilson also participates in two Tropical Medicine Research Centers that fund collaborative field studies in India and Brazil. The Wilson lab works toward application of molecular techniques to understand both human genetic and molecular parasitic determinants leading to the diverse forms of human leishmaniasis. Genotyping of subjects in large family studies in India and Brazil has revealed several immune-related genes potentially associated with the outcome of visceral leishmaniasis. Studies of parasite genomes, and polymorphisms within genomes, are revealing contributions of the parasite strain to pathologic changes observed in leishmaniasis.
Center for Gene Therapy of Cystic Fibrosis and other Genetic DiseasesCenter for Immunology and Immune-based DiseasesHolden Comprehensive Cancer CenterInstitute for Clinical and Translational ScienceNIH Vaccine Treatment and Evaluation Unit
Identifying functional microRNAs in macrophages with polarized phenotypes.
J Biol Chem.
2012 June 22. 287(26):21816-25.
Gaur Dixit U,
Stage-specific pathways of Leishmania infantum chagasi entry and phagosome maturation in macrophages.
2011 April 28. 6(4):e19000.
Leukocytes infiltrate the skin and draining lymph nodes in response to the protozoan Leishmania infantum chagasi.
2011 January. 79(1):108-17.
Proteomic examination of Leishmania chagasi plasma membrane proteins: Contrast between avirulent and virulent (metacyclic) parasite forms.
Proteomics Clin Appl.
2010 January. 4(1):4-16.
Differences in human macrophage receptor usage, lysosomal fusion kinetics and survival between logarithmic and metacyclic Leishmania infantum chagasi promastigotes.
2009 December. 11(12):1827-41.
Genetic admixture in Brazilians exposed to infection with Leishmania chagasi.
Ann Hum Genet.
2009 May. 73(Pt 3):304-13.
An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis.
2007 December 15. 179(12):8446-53.
Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan.
J Infect Dis.
2007 October 15. 196(8):1261-9.
Date Last Modified: 10/09/2013 -
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