Microbiology

Wendy J. Maury, PhD

Portrait

Professor of Microbiology

Contact Information

Office: 3-750 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Office Phone: 319-335-8021

Lab: 3-701E Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Phone: 319-335-7613

Email: wendy-maury@uiowa.edu
Web: Carver College of Medicine Interview

Education

BA, Botany, Duke University
MS, Botany, North Carolina State University
PhD, Biology, University of Virginia

Post Doctoral, Molecular Microbiology, National Institutes of Health-NIAID
Post Doctoral, Virology, National Institutes of Health-NIAID

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Microbiology Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

A goal of our research is to understand how enveloped viral glycoproteins bind to and mediate entry into permissive cells. An appreciation of the cellular attachment factors, receptors, internalization pathways and fusion events used by a virus to enter cells provides an avenue for the development of antiviral therapies. To this end, my laboratory primarily focuses on the filoviruses, Ebolavirus and Marburgvirus, but also investigates entry mechanisms of human immunodeficiency virus-1 (HIV-1). We have recently identified a novel cell surface receptor for filoviruses and are currently exploring the role of this family of cellular receptors in filovirus pathogenesis. In addition, studies in the lab have helped to elucidate the endosomal pathways used by filoviruses for entry and identified Ebola virus glycoprotein amino acids that are critical for productive Ebola virus infection. Stemming from this work are investigations into novel vaccine and antiviral therapeutic approaches designed to block filovirus infection.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Center for Immunology and Immune-based Diseases
Helen C. Levitt Center for Viral Pathogenesis
Holden Comprehensive Cancer Center

All Publications

Moller-Tank S, Maury W.  Phosphatidylserine receptors: Enhancers of enveloped virus entry and infection.  Virology.  2014 September 29. 468-470C:565-80.
[Link]

Li M, Ablan S, Miao C, Zheng Y, Fuller M, Rennert P, Maury W, Johnson M, Freed E, Liu S.  TIM-family proteins inhibit HIV-1 release.  Proc Natl Acad Sci U S A.  2014 September 2. 111(35):E3699-707.
[Link]

Moller-Tank S, Albritton L, Rennert P, Maury W.  Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry.  J Virol.  2014 June 15. 88(12):6702-13.
[Link]

Lennemann N, Rhein B, Ngundo E, Chandran K, Liu Q, Maury W.  Comprehensive functional analysis of N-linked glycans on Ebola virus GP1.  MBio.  2014 January 28. 5(1):e00862-13.
[Link]

Moller-Tank S, Kondratowicz A, Davey R, Rennert P, Maury W.  Role of the phosphatidylserine receptor TIM-1 in enveloped virus entry.  J Virol.  2013 August. 87(15):8327-41.
[Link]

Jones P, Maric M, Madison M, Maury W, Roller R, Okeoma C.  BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1).  Virology.  2013 March 30. 438:37-49.
[Link]

Oakland M, Maury W, McCray, Jr P, Sinn P.  Intrapulmonary versus nasal transduction of murine airways with GP64-pseudotyped viral vectors.  Mol Ther Nucleic Acids.  2013 January 19. 2:e69.
[Link]

Kondratowicz A, Hunt C, Davey R, Cherry S, Maury W.  AMP-Activated Protein Kinase Is Required for the Macropinocytic Internalization of Ebolavirus.  J Virol.  2013 January. 87(2):746-55.
[Link]

Hunt C, Lennemann N, Maury W.  Filovirus entry: a novelty in the viral fusion world.  Viruses.  2012 February. 4(2):258-75.
[Link]

Sloat B, Kiguchi K, Xiao G, DeGiovanni J, Maury W, Cui Z.  Transcutaneous DNA immunization following waxing-based hair depilation.  J Control Release.  2012 January 10. 157(1):94-102.
[Link]

Kondratowicz A, Maury W.  Ebolavirus: a brief review of novel therapeutic targets.  Future Microbiol.  2012 January. 7(1):1-4.
[Link]

Brindley M, Hunt C, Kondratowicz A, Bowman J, Sinn P, McCray P, Quinn K, Weller M, Chiorini J, Maury W.  Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein.  Virology.  2011 July 5. 415(2):83-94.
[Link]

Kondratowicz A, Lennemann N, Sinn P, Davey R, Hunt C, Moller-Tank S, Meyerholz D, Rennert P, Mullins R, Brindley M, Sandersfeld L, Quinn K, Weller M, McCray P, Chiorini J, Maury W.  T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus.  Proc Natl Acad Sci U S A.  2011 May 17. 108(20):8426-31.
[Link]

Oh C, Price J, Brindley M, Widrlechner M, Qu L, McCoy J, Murphy P, Hauck C, Maury W.  Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.  Virol J.  2011 April 23. 8:188.
[Link]

Kraus G, Mengwasser J, Maury W, Oh C.  Synthesis of chroman aldehydes that inhibit HIV.  Bioorg Med Chem Lett.  2011 March 1. 21(5):1399-401.
[Link]

Hunt C, Kolokoltsov A, Davey R, Maury W.  The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus.  J Virol.  2011 January. 85(1):334-47.
[Link]

Quinn K, Brindley M, Weller M, Kaludov N, Kondratowicz A, Hunt C, Sinn P, McCray P, Stein C, Davidson B, Flick R, Mandell R, Staplin W, Maury W, Chiorini J.  Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.  J Virol.  2009 October. 83(19):10176-86.
[Link]

Maury W, Price J, Brindley M, Oh C, Neighbors J, Wiemer D, Wills N, Carpenter S, Hauck C, Murphy P, Widrlechner M, Delate K, Kumar G, Kraus G, Rizshsky L, Nikolau B.  Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum.  Virol J.  2009 July 13. 6:101.
[Link]

Brindley M, Widrlechner M, McCoy J, Murphy P, Hauck C, Rizshsky L, Nikolau B, Maury W.  Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris.  Virol J.  2009 January 20. 6:8.
[Link]

Maury W, Oaks J.  Equine infectious anemia virus and macrophages.  Horizon Press.  2009. 

Birt D, Widrlechner M, Hammer K, Hillwig M, Wei J, Kraus G, Murphy P, McCoy J, Wurtele E, Neighbors J, Wiemer D, Maury W, Price J.  Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents.  Pharm Biol.  2009. 47(8):774-82.
[Link]

Brindley M, Zhang B, Montelaro R, Maury W.  An equine infectious anemia virus variant superinfects cells through novel receptor interactions.  J Virol.  2008 October. 82(19):9425-32.
[Link]

Tallmadge R, Brindley M, Salmans J, Mealey R, Maury W, Carpenter S.  Development and characterization of an equine infectious anemia virus Env-pseudotyped reporter virus.  Clin Vaccine Immunol.  2008 July. 15(7):1138-40.
[Link]

Birt D, Widrlechner M, Lalone C, Wu L, Bae J, Solco A, Kraus G, Murphy P, Wurtele E, Leng Q, Hebert S, Maury W, Price J.  Echinacea in infection.  Am J Clin Nutr.  2008 February. 87(2):488S-92S.
[Link]

Brindley M, Maury W.  Equine infectious anemia virus entry occurs through clathrin-mediated endocytosis.  J Virol.  2008 February. 82(4):1628-37.
[Link]

Leontiev V, Maury W, Hadany L.  Drug induced superinfection in HIV and the evolution of drug resistance.  Infect Genet Evol.  2008 January. 8(1):40-50.
[Link]

Sinn P, Goreham-Voss J, Arias A, Hickey M, Maury W, Chikkanna-Gowda C, McCray P.  Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.  Hum Gene Ther.  2007 December. 18(12):1244-52.
[Link]

Biglione S, Byers S, Price J, Nguyen V, Bensaude O, Price D, Maury W.  Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex.  Retrovirology.  2007 July 11. 4:47-56.
[Link]

Brindley M, Hughes L, Ruiz A, McCray P, Sanchez A, Sanders D, Maury W.  Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events.  J Virol.  2007 July. 81(14):7702-9.
[Link]

Sedore S, Byers S, Biglione S, Price J, Maury W, Price D.  Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.  Nucleic Acids Res.  2007. 35(13):4347-58.
[Link]

Brindley M, Maury W.  Endocytosis and a low-pH step are required for productive entry of equine infectious anemia virus.  J Virol.  2005 December. 79(23):14482-8.
[Link]

Maury W, Thompson R, Jones Q, Bradley S, Denke T, Baccam P, Smazik M, Oaks J.  Evolution of the equine infectious anemia virus long terminal repeat during the alteration of cell tropism.  J Virol.  2005 May. 79(9):5653-64.
[Link]

Hines R, Sorensen B, Shea M, Maury W.  PU.1 binding to ets motifs within the equine infectious anemia virus long terminal repeat (LTR) enhancer: regulation of LTR activity and virus replication in macrophages.  J Virol.  2004 April. 78(7):3407-18.
[Link]

Reed-Inderbitzin E, Maury W.  Cellular specificity of HIV-1 replication can be controlled by LTR sequences.  Virology.  2003 September 30. 314(2):680-95.
[Link]

Shore S, Byers S, Maury W, Price D.  Identification of a novel isoform of Cdk9.  Gene.  2003 March 27. 307:175-82.
[Link]

Maury W, Wright P, Bradley S.  Characterization of a cytolytic strain of equine infectious anemia virus.  J Virol.  2003 February. 77(4):2385-99.
[Link]

Hines R, Maury W.  DH82 cells: a macrophage cell line for the replication and study of equine infectious anemia virus.  J Virol Methods.  2001 June. 95(1-2):47-56.
[Link]

Faga B, Maury W, Bruckner D, Grose C.  Identification and mapping of single nucleotide polymorphisms in the varicella-zoster virus genome.  Virology.  2001 February 1. 280(1):1-6.
[Link]

Maury W, Bradley S, Wright B, Hines R.  Cell specificity of the transcription-factor repertoire used by a lentivirus: motifs important for expression of equine infectious anemia virus in nonmonocytic cells.  Virology.  2000 February 15. 267(2):267-78.
[Link]

Maury W, Oaks J, Bradley S.  Equine endothelial cells support productive infection of equine infectious anemia virus.  J Virol.  1998 November. 72(11):9291-7.
[Link]

Maury W.  Regulation of equine infectious anemia virus expression.  J Biomed Sci.  1998. 5(1):11-23.
[Link]

Maury W, Perryman S, Oaks J, Seid B, Crawford T, McGuire T, Carpenter S.  Localized sequence heterogeneity in the long terminal repeats of in vivo isolates of equine infectious anemia virus.  J Virol.  1997 July. 71(7):4929-37.
[Link]

Maury W.  Monocyte maturation controls expression of equine infectious anemia virus.  J Virol.  1994 October. 68(10):6270-9.
[Link]

Maury W, Carpenter S, Graves K, Chesebro B.  Cellular and viral specificity of equine infectious anemia virus Tat transactivation.  Virology.  1994 May 1. 200(2):632-42.
[Link]

Biswas P, Poli G, Kinter A, Justement J, Stanley S, Maury W, Bressler P, Orenstein J, Fauci A.  Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells.  J Exp Med.  1992 September 1. 176(3):739-50.
[Link]

Chesebro B, Wehrly K, Maury W.  Differential expression in human and mouse cells of human immunodeficiency virus pseudotyped by murine retroviruses.  J Virol.  1990 September. 64(9):4553-7.
[Link]

Kinter A, Poli G, Maury W, Folks T, Fauci A.  Direct and cytokine-mediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells.  J Virol.  1990 September. 64(9):4306-12.
[Link]

Potts B, Maury W, Martin M.  Replication of HIV-1 in primary monocyte cultures.  Virology.  1990 April. 175(2):465-76.
[Link]

Maury W, Potts B, Rabson A.  HIV-1 infection of first-trimester and term human placental tissue: a possible mode of maternal-fetal transmission.  J Infect Dis.  1989 October. 160(4):583-8.
[Link]

Duh E, Maury W, Folks T, Fauci A, Rabson A.  Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.  Proc Natl Acad Sci U S A.  1989 August. 86(15):5974-8.
[Link]

Koenig S, Hirsch V, Olmsted R, Powell D, Maury W, Rabson A, Fauci A, Purcell R, Johnson P.  Selective infection of human CD4+ cells by simian immunodeficiency virus: productive infection associated with envelope glycoprotein-induced fusion.  Proc Natl Acad Sci U S A.  1989 April. 86(7):2443-7.
[Link]

Maury W, Potts B, Rabson A.  Infection of human placental tissue with HIV-1.  Cold Spring Harbor Laboratory.  1989. 89:133.

Maury W, Huber S, Moreland D.  Effects of Magnesium on Intact Chloroplasts : II. CATION SPECIFICITY AND INVOLVEMENT OF THE ENVELOPE ATPase IN (SODIUM) POTASSIUM/PROTON EXCHANGE ACROSS THE ENVELOPE.  Plant Physiol.  1981 December. 68(6):1257-63.
[Link]

Davis J, Olender E, Maury W, McDaniel R.  Alpha-adrenergic regulation of cholinergic responses in rat parotid acinar cells.  Mol Pharmacol.  1980 November. 18(3):356-61.
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Huber S, Maury W.  Effects of Magnesium on Intact Chloroplasts: I. EVIDENCE FOR ACTIVATION OF (SODIUM) POTASSIUM/PROTON EXCHANGE ACROSS THE CHLOROPLAST ENVELOPE.  Plant Physiol.  1980 February. 65(2):350-4.
[Link]

Davis J, Maury W.  Clonidine and related imidazolines are postsynaptic alpha adrenergic antagonists in dispersed rat parotid cells.  J Pharmacol Exp Ther.  1978 November. 207(2):425-30.
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Date Last Modified: 06/07/2014 - 21:56:23