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Associate Professor of MicrobiologyAssociate Professor of
Office: 2202 Medical Education and Research Facility375 Newton RdIowa City, IA 52242
Lab: 2216 Medical Education and Research Facility375 Newton RdIowa City, IA 52242
Email: email@example.comWeb: Carver College of Medicine InterviewWeb: The immortal HeLa at Iowa
BS, Biology, St John's UniversityPhD, Genetics, University of Wisconsin-Madison
Post Doctorate, Cancer Biology, Fred Hutchinson Cancer Research Center
Department of Microbiology Graduate ProgramFree Radical and Radiation Biology Graduate ProgramInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in InformaticsInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
One of my primary interests is in how epithelial cells become immortal and subsequently malignant after infection with human papillomavirus (HPV). We are also studying how telomere loss and other factors are involved in induction of cellular senescence and aging. More recent studies have focused on the role of adipocytes in the development of diabetes and other metabolic disorders. Specific areas of research are:
-Determining how bacterial toxins and environmental pollutants disrupt metabolism through their effects on adipocyte differentiation and function
-Developing strategies to inhibit the growth of HPV transformed cells
-Defining the role of telomere loss in aging and cancer
-Characterizing how cellular genes are regulated by HPV E6 and E7 during the process of infection and transformation
Cancer and Aging ProgramCenter for Bioinformatics and Computational BiologyCenter for Gene Therapy of Cystic Fibrosis and other Genetic DiseasesHelen C. Levitt Center for Viral PathogenesisHolden Comprehensive Cancer Center
Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin, and abnormal glucose tolerance in rabbits: possible role in diabetes.
2015 February 24. 6(2):e02554.
PCB126 inhibits adipogenesis of human preadipocytes.
Toxicol In Vitro.
2015 February. 29(1):132-41.
Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells.
2013 November. 446(1-2):325-33.
Staphylococcal superantigens stimulate immortalized human adipocytes to produce chemokines.
2013 October 30. 8(10):e77988.
DNA damage responses and oxidative stress in dyskeratosis congenita.
2013 October 4. 8(10):e76473.
Vande Pol S,
Papillomavirus E6 oncoproteins.
2013 October. 445(1-2):115-37.
Enhanced radiation sensitivity in HPV-positive head and neck cancer.
2013 August 1. 73(15):4791-800.
Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers.
2013 March 14. 6(3):295-319.
Dyskeratosis Congenita Dermal Fibroblasts are Defective in Supporting the Clonogenic Growth of Epidermal Keratinocytes.
2012 December. 3(6):427-37.
The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency.
Antioxid Redox Signal.
2011 March 15. 14(6):985-97.
Date Last Modified: 10/09/2015 -
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