Microbiology

Aloysius J. Klingelhutz, PhD

Portrait

Associate Professor of Microbiology
Associate Professor of Radiation Oncology

Contact Information

Office: 2202 Medical Education and Research Facility
375 Newton Rd
Iowa City, IA 52242
Office Phone: 319-335-7788

Lab: 2216 Medical Education and Research Facility
375 Newton Rd
Iowa City, IA 52242
Phone: 319-335-8499

Email: al-klingelhutz@uiowa.edu
Web: Carver College of Medicine Interview
Web: The immortal HeLa at Iowa

Education

BS, Biology, St John's University
PhD, Genetics, University of Wisconsin, Madison

Post Doctoral, Cancer Biology, Fred Hutchinson Cancer Research Center

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Microbiology Graduate Program
Free Radical and Radiation Biology Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

One of my primary interests is in how epithelial cells become immortal and subsequently malignant after infection with human papillomavirus (HPV). We are also studying how telomere loss and other factors are involved in induction of cellular senescence and aging. More recent studies have focused on the role of adipocytes in the development of diabetes and other metabolic disorders. Specific areas of research are:

-Determining how bacterial toxins and environmental pollutants disrupt metabolism through their effects on adipocyte differentiation and function

-Developing strategies to inhibit the growth of HPV transformed cells

-Defining the role of telomere loss in aging and cancer

-Characterizing how cellular genes are regulated by HPV E6 and E7 during the process of infection and transformation

Center, Program and Institute Affiliations

Cancer and Aging Program
Center for Bioinformatics and Computational Biology
Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Helen C. Levitt Center for Viral Pathogenesis
Holden Comprehensive Cancer Center

Selected Publications

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Gourronc F, Rockey W, Thiel W, Giangrande P, Klingelhutz A.  Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells.  Virology.  2013 November. 446(1-2):325-33.
[Link]

Vu B, Gourronc F, Bernlohr D, Schlievert P, Klingelhutz A.  Staphylococcal superantigens stimulate immortalized human adipocytes to produce chemokines.  PLoS One.  2013 October 30. 8(10):e77988.
[Link]

Pereboeva L, Westin E, Patel T, Flaniken I, Lamb L, Klingelhutz A, Goldman F.  DNA damage responses and oxidative stress in dyskeratosis congenita.  PLoS One.  2013 October 4. 8(10):e76473.
[Link]

Vande Pol S, Klingelhutz A.  Papillomavirus E6 oncoproteins.  Virology.  2013 October. 445(1-2):115-37.
[Link]

Kimple R, Smith M, Blitzer G, Torres A, Martin J, Yang R, Peet C, Lorenz L, Nickel K, Klingelhutz A, Lambert P, Harari P.  Enhanced radiation sensitivity in HPV-positive head and neck cancer.  Cancer Res.  2013 August 1. 73(15):4791-800.
[Link]

Hernandez L, Flenker K, Hernandez F, Klingelhutz A, McNamera J, Giangrande P.  Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers.  Pharmaceuticals (Basel).  2013 March 14. 6(3):295-319.
[Link]

Buckingham E, Goldman F, Klingelhutz A.  Dyskeratosis Congenita Dermal Fibroblasts are Defective in Supporting the Clonogenic Growth of Epidermal Keratinocytes.  Aging Dis.  2012 December. 3(6):427-37.
[Link]

Westin E, Aykin-Burns N, Buckingham E, Spitz D, Goldman F, Klingelhutz A.  The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency.  Antioxid Redox Signal.  2011 March 15. 14(6):985-97.
[Link]

Date Last Modified: 08/13/2014 - 14:17:19