Microbiology

John T. Harty, PhD

Portrait

Professor of Microbiology
Professor of Pathology

Contact Information

Office: 3-530 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Office Phone: 319-335-9720

Lab: 3-501B Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Phone: 319-335-9919

Email: john-harty@uiowa.edu
Web: Harty Lab Website

Education

BS, Biology, University of Minnesota
PhD, Microbiology, University of Minnesota

Post Doctoral, Scripps Clinical and Research Foundation, La Jolla, CA
Post Doctoral, Howard Hughes Medical Institute, University of Washington

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Microbiology Graduate Program
Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

In my laboratory we combine cellular and molecular approaches to dissect T cell mediated resistance to pathogens. Specifically, we use murine infection with Listeria monocytogenes, a bacterial pathogen or lymphocytic choriomeningitis virus, as model systems to understand the biology of CD8+ T cell mediated immunity to infection. We are also studying the factors that determine CD8 T cell mediated immunity against liver-stage malaria infection. Current projects involve:

1. Regulation of memory T cell development

2. Effector mechanisms of CD8 T cells in whole animal models of infectious disease

3. T cell homeostasis in response to infection

4. T cell mediated immunopathology after virus infection

5. CD8 T cell immunity against liver-stage malaria

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases

Selected Publications

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Richer M, Nolz J, Harty J.  Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling.  Immunity.  2013 January 24. 38(1):140-52.
[Link]

Nolz J, Rai D, Badovinac V, Harty J.  Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.  Proc Natl Acad Sci U S A.  2012 April 17. 109(16):6199-204.
[Link]

Butler N, Moebius J, Pewe L, Traore B, Doumbo O, Tygrett L, Waldschmidt T, Crompton P, Harty J.  Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.  Nat Immunol.  2011 December 11. 13(2):188-95.
[Link]

Butler N, Schmidt N, Vaughan A, Aly A, Kappe S, Harty J.  Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites.  Cell Host Microbe.  2011 June 16. 9(6):451-62.
[Link]

Nolz J, Harty J.  Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection.  Immunity.  2011 May 27. 34(5):781-93.
[Link]

Schmidt N, Butler N, Badovinac V, Harty J.  Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.  PLoS Pathog.  2010 July 15. 6(7):e1000998.
[Link]

Pham N, Pewe L, Fleenor C, Langlois R, Legge K, Badovinac V, Harty J.  Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.  Proc Natl Acad Sci U S A.  2010 July 6. 107(27):12198-203.
[Link]

Schmidt N, Podyminogin R, Butler N, Badovinac V, Tucker B, Bahjat K, Lauer P, Reyes-Sandoval A, Hutchings C, Moore A, Gilbert S, Hill A, Bartholomay L, Harty J.  Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.  Proc Natl Acad Sci U S A.  2008 September 16. 105(37):14017-22.
[Link]

Badovinac V, Haring J, Harty J.  Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.  Immunity.  2007 June. 26(6):827-41.
[Link]

Badovinac V, Messingham K, Jabbari A, Haring J, Harty J.  Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination.  Nat Med.  2005 July. 11(7):748-56.
[Link]

Date Last Modified: 06/07/2014 - 21:56:23