Internal Medicine

Francis J. Miller, Jr., MD


Professor of Internal Medicine  - Cardiovascular Medicine
Professor of Radiation Oncology

Contact Information



MD, The University of Iowa

Fellowship, Cardiology, University of Iowa Hospitals and Clinics
Residency, University of Texas Southwestern Medical Center

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

The primary goal of Dr. Miller’s research program is to understand the molecular and cellular mechanisms by which the NADPH oxidases contribute to the pathogenesis of vascular disease and identify novel therapeutic targets. Ongoing studies are (1) examining the role of chronic inflammation in accelerating vascular injury via Nox1 NAPDH oxidase, and (2) identifying molecular mechanisms of Nox4 regulation in redox homeostasis and understanding how microRNA-mediated mediated changes in Nox4 can coordinate pathways implicated in vascular disease. Furthermore, studies are examining RNA aptamers as a novel approach for cell specific delivery of vascular therapeutics. As a practicing cardiologist, Dr. Miller is interested in confirming observations made at the bench with human disease. His findings are resulting in a better understanding of vascular disease and the development of new strategies for the treatment of atherosclerosis, stent restenosis, graft failure, and myocardial infarction.

Date Last Modified: 08/28/2015 - 13:31:39