Internal Medicine

Anil K. Chauhan, MTech, PhD

Portrait

Associate Professor of Internal Medicine  - Hematology, Oncology and Blood and Marrow Transplantation

Contact Information

Lab: 3160 ML
Iowa City, IA 52242

Email: anil-chauhan@uiowa.edu
Web: More information

Education

B.Sc., Biology, Botany, Zoology, Chemistry, University of Delhi, India
M. Sc. (Biotechnology) , Biotechnology, Devi Ahilya University, India
M. Tech. (Biotechnology), Fermentation and Biotechnology, Anna University, India
PhD, Alternative splicing, International Centre for Genetic Engineering and Biotechnology (UN organization), Trieste, Italy

Post Doctoral, International centre for Genetic Engg and Biotechnology
Post Doctoral, Thrombosis and Inflammation, Immune Disease Institute and Harvard Medical School
Post Doctoral, Thrombosis and Inflammation, CBR Institute for Biomedical Research, Boston, MA, USA

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Medical Scientist Training Program

Research Summary

Research in laboratory is focused on the role of adhesion molecules in vascular diseases associated with thrombosis and inflammation. By using state-of-the-art technique, intravital imaging, we study the role of adhesion molecules in regulating blood cell-endothelial (platelet and leukocyte) interaction followed by stimulation/ injury in vivo. In addition, research projects uses molecular and cellular techniques, combined with genetically modified mice to investigate the role of novel molecules in the pathophysiology of acute ischemic stroke and atherosclerosis. Using murine models, we hope to understand the pathophysiology of human vascular inflammatory diseases that may lead to development of novel therapies, thus improving human health. Current research project includes: 1) Role of ADAMTS13-VWF axis in acute ischemic stroke and atherosclerosis. 2) Mechanistic role of fibronectin alternative splicing in early and advanced atherosclerosis.

All Publications

Barr J, Chauhan A, Schaeffer G, Hensen J, Motto D.  Red blood cells mediate the onset of thrombosis in ferric-chloride murine model.  Blood.  2013 May 2. 121(18):3733-41.
[PubMed]

Dayal S, Wilson K, Motto D, Miller F, Chauhan A, Lentz S.  Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis.  Circulation.  2013 February 20. 127(12):1308-16.
[PubMed]

Gandhi C, Motto D, Jensen M, Lentz S, Chauhan A.  ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.  Blood.  2012 December 20. 120(26):5224-30.
[PubMed]

Khan M, Motto D, Lentz S, Chauhan A.  ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice..  Journal of Thrombosis and Haemostasis.  2012 August. 10(8):1665-71.
[PubMed]

Khan M, Gandhi C, Chauhan N, Stevens J, Motto D, Lentz S, Chauhan A.  Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice..  Stroke.  2012 August. 43(5):1376-82.
[PubMed]

Gandhi C, Khan M, Lentz S, Chauhan A.  ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice..  Blood.  2012 March. 119(10):2385-91.
[PubMed]

Dayal S, Chauhan A, Jensen M, Leo L, Lynch C, Faraci F, Kruger W, Lentz S.  Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia..  Blood.  2012 March. 119(13):3176-83.
[PubMed]

Flick M, Chauhan A, Frederick M, Talmage K, Kombrinck K, Miler W, Mullins E, Palumbo J, Zheng X, Esmon N, Esmon C, Thornton S, Becker A, Pelc l, Cera E, Wagner D, Degen J.  The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A..  Blood.  2011 June. 117(23):6326-37.
[PubMed]

Brill A, Fuchs T, Chauhan A, Yang J, DeMeyer S, Kollenberger M, Wakefield T, Lammle B, Massberg S, Wagner D.  von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models..  Blood.  2011 January 27. 117(4):1400-7.
[PubMed]

Chauhan A.  A role of erythrocytes in a murine model of thrombosis.  ATVB.  2011. 

Chauhan A.  Extra domain A of fibronectin aggravates ischemia/reperfusion brain injury by enhancing thrombosis and inflammation.  ATVB.  2011. 

Chauhan A.  Regulation of vascular thrombosis and P-selectin expression by endothelial PPARy.  ATVB.  2011. 

Chauhan A.  EDA containing FN aggravates ischemic brain injury in mice.  Blood.  2010. 

Banno F, Chauhan A, Miyata T.  The function of ADAMTS13 in thrombogenesis in vivo: insights from mutant mice..  Internatiomal Journal of Hematology.  2010 January. 91(1):30-5.
[PubMed]

Zhao B, Chauhan A, Cannault M, Patten I, Yang J, Dockal M, Scheiflinger F, Wagner D.  von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke..  Blood.  2009 October 8. 114(15):3329-34.
[PubMed]

Brill A, Chauhan A, Cannault M, Walsh M, Bergmeier W, Wagner D.  Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion..  Cardiovascular Research.  2009 October. 84(1):137-44.
[PubMed]

Kisucka J, Chauhan A, Zhao B, Patten I, Yesilaltay A, Krieger M, Wagner D.  Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis..  Blood.  2009 June 4. 113(23):6015-22.
[PubMed]

Banno F, Chauhan A, Kokame K, Yang J, Miyata S, Wagner D, Miyata T.  The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation..  Blood.  2009 May 21. 113(21):5323-9.
[PubMed]

Chauhan A.  . Image analysis of thrombus formation in ADAMTS13-mutant mice.  Journal of Thrombosis and Hemostasis.  2009. 7(S2):PP-MO-093.

Chauhan A.  Oxidative stress activates ADAM17 (TACE) in platelets and induces GPIb-alpha sheding in a p38 kinase-dependent fashion.  Journal of Thrombosis and Hemostasis.  2009. 7(S2):OC-TU-045.

Chauhan A.  Prolonged survival following microbial infection in mice expressing the thrombin anticoagulant mutant W215/E217A.  Journal of Thrombosis and Hemostasis.  2009. 7(S2):OC-TH-063.

Chauhan A.  Recombinant ADAMTS13 improves neurological outcome in experimental stroke in mice.  Blood.  2009. 

Chauhan A.  factor in primary platelet adhesion and thrombus formation: lessons from mutant mice.  Thromb & Haemost.  2008. 99(2):264-70.

Chauhan A.  VWF-cleaving protease ADAMTS13 reduces brain injury following ischemic stroke in mice: Essential role for VWF in stroke.  Blood.  2008. 112(11):259.

Chauhan A.  . Mice engineered to express a form of thrombin favoring protein C are resistant to S. aureus-induces sepsis.  Blood.  2007. 110:267.

Chauhan A.  Absence of ADAMTS13 on a VWF-deficient background is no longer prethrombotic in a murine model of arterial thrombosis.  Journal of Thombosis and Hemostasis.  2007. 5(S2):P-S-278.

Chauhan A.  Deficiency of the VWF-cleaving protease ADAMTs13 result sin increased leukocyte rolling and adhesion in mice.  Blood.  2007. 110:290.

Chauhan A.  Peroxiredoxin, PrdX1 plays an important role in inflammation and early atherosclerosis .  Journal of Thrombosis and Hemostasis.  2007. 5(S2).

Chauhan A.  ten Cate H. Characterization of the role of platelet adhesion molecules in a murine model of photosensitizer-induced stroke.  Journal of Thrombosis and Hemostasis.  2007. 5(S2):P-W-455.

Chauhan A.  Formation of platelet strings and microthrombi in the presence of ADAMTS13 inhibitor does not require P-selectin or β3 integrin.  Blood.  2006. 108(11):1782.

Chauhan A.  Pro-thrombotic effects of EDA containing isoform of fibronectin.  Gordon Research Conference on Fibronectin, Integrins and Related Molecules,” Il Ciocco, Lucca, Italy.  2006. 

Chauhan A.  von Willebrand Factor and Factor VIII are independently required to form stable occlusive thrombi in injured veins.  Blood.  2006. 108(11):1789.

Chauhan A.  . Formation of platelet strings and microthrombi in the presence of ADAMTS13 inhibitor does not require P-selectin or β3 .  integrinsGordon Research Conference on Hemostasis 2005, Waterville, ME.  2005. 

Chauhan A.  Elevated levels of homocysteine compromise blood-brain barrier integrity in mice.  Blood.  2005. 106(11):3856.

Chauhan A.  Shigatoxin triggers Thrombotic Thrombocytopenic Purpura in genetically susceptible ADAMTS13-deficient mice.  Blood.  2005. 106:214a.

Chauhan A.  The metalloprotease ADAMTS13 is a natural anti-thrombotic.  Blood.  2005. 106(11):409.

Chauhan A.  Sustained platelet adhesion and VWF string froomation in stimulated venules of Adamts13-/- mice.  Journal of Thrombosis and Hemostasis.  2003. 3(S1).

Chauhan A.  Regulated splicing of the fibronectin EDA exon (FN) is essential for proper skin wound healing and normal life span.  Mol. Biol. Cell.  2002. 8(supp S).

Chauhan A.  Prothrombotic effects of fibronectin isoforms containing the EDA domain.  Journal of Thrombosis and Hemostasis.  5(S2):P-M-265.

Date Last Modified: 07/22/2014 - 15:47:50