Dermatology

George J. Giudice, MA, PhD

Portrait

Professor of Dermatology

Contact Information

Office: 2080 Medical Laboratories
200 Hawkins Drive
Iowa City, IA 52242

Email: george-giudice@uiowa.edu
Web: Dermatology Department
Web: Immunology Graduate Program

Education

BS, Biology and Chemistry, High Honors, University of Illinois
MA, Biology, Princeton University, Princeton NJ
PhD, Cell Biology, Department of Biology, Princeton University, Princeton NJ

Fellowship, Biology Department/Malcom S. Steinberg Lab, Princeton University, New Jersey
Post Doctoral, NIH Molecular Genetics and Cell Biology, University of Chicago/Elaine V. Fuchs Lab

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

BP180, a protein expressed by keratinocytes in the basal layer of the epidermis, plays a prominent role in several skin diseases – both acquired and inherited – that are characterized by a detachment of the epidermis from the underlying basement membrane. Through the use of both in vivo and in vitro model systems, our laboratory has shown that autoantibodies against BP180 play a critical role in the pathogenesis of one such disease, bullous pemphigoid. We identified key factors in the multi-step pathogenic mechanism of this disease. Our recent work in collaboration with Dr. Janet Fairley (Head of Dermatology, U. Iowa) represents the first time a pathogenic role has been ascribed to a specific IgE class autoantibody in an autoimmune disease. Our studies of blistering skin diseases have provided insights into the structural and functional properties of the BP180 protein. Future directions for our lab include identifying BP180 interactor molecules, probing structure/function relationships within BP180, characterizing the cell signaling properties of this protein (both autoantibody-mediated and ligand-mediated), and using this information to develop novel diagnostic and therapeutic strategies for various disorders of the dermal-epidermal junction.

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases

All Publications

Van den Bergh F, Eliason S, Burmeister B, Giudice G.  Collagen XVII (BP180) modulates keratinocyte expression of the pro-inflammatory chemokine, IL-8.  Exp Dermatol.  2012 August. 21(8):605-611.
[Link]

Messingham K, Onoh A, Vanderah E, Giudice G, Fairley J.  Functional characterization of an IgE-class monoclonal antibody specific for the bullous pemphigoid autoantigen, BP180.  Hybridoma.  2012 April. 31(2):111-7.
[Link]

Lin L, Betsuyaku T, Heimbach L, Li N, Rubenstein D, Shapiro S, An L, Giudice G, Diaz L, Senior R, Liu Z.  Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.  Matrix Biol.  2012 January. 31(1):38-44.
[Link]

Van Den Bergh F, Eliason S, Giudice G.  Type XVII collagen (BP180) can function as a cell−matrix adhesion molecule via binding to laminin 332.  Matrix Biol.  2011. 30(2):100-108.
[Link]

Wong M, Giudice G, Fairley J.  Autoimmunity in bullous pemphigoid .  G Ital Dermatol Venereol.  2009 August. 144(4):411-21.
[PubMed]

Messingham K, Noe M, Chapman M, Giudice G, Fairley J.  A novel ELISA reveals high frequencies of BP180-specific IgE production in bullous pemphigoid.  J Immunol Methods.  2009 July 31. 346(1-2):18-25.
[Link]

Wong M, Giudice G, Fairley J.  Autoimmunity in Bullous Pemphigoid.  Giornale Italiano di Dermatologia e Venereologia.  2009. 144(4):411-21.

Liu Z, Sui W, Zhao M, Li Z, Li N, Thresher R, Giudici G, Fairley J, Sitaru C, Zillikens D, Ning G, Marinkovich M, Diaz L.  Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model.  J Autoimmun.  2008 December. 31(4):331-8.
[Link]

Fairley J, Burnett C, Fu C, Larson D, Fleming M, Giudice G.  A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice.  J Invest Dermatol.  2007 November. 127(11):2605-11.
[Link]

Van den Bergh F, Fu C, Olague-Marchan M, Giudice G.  The NC16A domain of collagen XVII plays a role in triple helix assembly and stability.  Biochem Biophys Res Commun.  2006 December 1. 350(4):1032-7.
[Link]

Fu C, Giudice G, Van de Bergh F.  Protein structural analysis of BP180 mutant isoforms linked to non-Herlitz junctional epidermolysis bullosa.  J Invest Dermatol.  2006 January. 126(1):232-4.
[Link]

Fairley J, Fu C, Giudice G.  Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid.  J Invest Dermatol.  2005 September. 125(3):467-72.
[Link]

Hacker-Foegen M, Zillikens D, Giudice G, Liu M.  T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis.  Clin Immunol.  2004 November. 113(2):179-86.
[Link]

Fairley J, Woodley D, Chen M, Giudice G, Lin M.  A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading.  J Am Acad Dermatol.  2004 July. 51(1):118-22.
[Link]

Dimson O, Giudice G, Fu C, Van de Bergh F, Warren S, Janson M, Fairley j.  Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid.  J Invest Dermatol.  2003 May. 120(5):784-8.
[Link]

Van den Bergh F, Giudice G.  BP180 (type XVII collagen) and its role in cutaneous biology and disease.  Advances in Dermatology.  2003. 

Warren S, Arteaga L, Rivitti E, Aoki V, Hans-Filho G, Qaqish B, Lin M, Guidice G, Diaz L.  The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus.  J Invest Dermatol.  2003 January. 120(1):104-8.
[Link]

Chen R, Fairley J, Zhao M, Giudice G, Zillikens D, Diaz L, Liu Z.  Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation.  J Immunol.  2002 October. 169(7):3987-92.
[PubMed]

Lin M, Fu C, Olague-Marchan M, Hacker M, Zillikens D, Giudice G, Fairley J.  Autoimmune responses in patients with linear IgA bullous dermatosis: both autoantibodies and T lymphocytes recognize the NC16A domain of the BP180 molecule.  Clin Immunol.  2002 March. 102(3):310-9.
[Link]

Lin M, Fu C, Giudice G, Olague-Marchan M, Lazaro A, Stastny P, Diaz L.  Epitopes targeted by bullous pemphigoid T lymphocytes and autoantibodies map to the same sites on the bullous pemphigoid 180 ectodomain.  J Invest Dermatol.  2000 December. 115(6):955-61.
[Link]

Schmidt E, Reimer S, Kruse N, Jainta S, Bröcker E, Marinkovich M, Giudice G, Zillikens D.  Autoantibodies to BP180 associated with bullous pemphigoid release interleukin-6 and interleukin-8 from cultured human keratinocytes.  J Invest Dermatol.  2000 November. 115(5):842-8.
[Link]

Warren S, Lin M, Giudice G, Hoffmann R, Hans-Filho G, Aoki V, Rivitti E, Santos V, Diaz L.  The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research.  N Engl J Med.  2000 July 6. 343(1):23-30.
[Link]

Olague-Marchan M, Twining S, Hacker M, McGrath J, Diaz L, Giudice G.  A disease-associated glycine substitution in BP180 (type XVII collagen) leads to a local destabilization of the major collagen triple helix.  Matrix Biol.  2000 July. 19(3):223-33.
[Link]

Mascaró Jr J, Zillikens D, Giudice G, Caux F, Fleming M, Katz H, Diaz L.  A subepidermal bullous eruption associated with IgG autoantibodies to a 200 kd dermal antigen: the first case report from the United States.  J Am Acad Dermatol.  2000 February. 42(2 Pt 2):309-15.
[Link]

Gharia M, Fairley J, Lin M, Liu Z, Giudice G, Diaz L.  Autoimmune Diseases of the Skin.  Lippincott-Raven, Philadelphia, PA.  2000. 

Diaz L, Giudice G.  End of the century overview of skin blisters.  Arch Dermatol.  2000. 

Liu Z, Shapior S, Zhou X, Twinning S, Senior R, Giudice G, Fairley J, Diaz L.  A critical role for neutrophil elastase in experimental bullous pemphigoid.  J Clin Invest.  2000 January. 105(1):113-23.
[Link]

Lin M, Fu C, Aoki V, Hans-Filho G, Rivitti E, Moraes J, Moraes M, Lazaro A, Giudice G, Stastny P, Diaz L.  Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem).  J Clin Invest.  2000 January. 105(2):207-13.
[Link]

Zillikens D, Herzele K, Georgi M, Schmidt E, Chimanovitch I, Schumann H, Mascaro Jr J, Diaz L, Bruckner-Tuderman L, Bröcker E, Giudice G.  Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP1801.  J Invest Dermatol.  1999 December. 113(6):947-53.
[Link]

Lin M, Gharia M, Fu C, Olague-Marchan M, Hacker M, Harman K, Bhogal B, Black M, Diaz L, Giudice G.  Molecular mapping of the major epitopes of BP180 recognized by herpes gestationis autoantibodies.  Clin Immunol.  1999 September. 92(3):285-9.
[PubMed]

Zillikens D, Caux F, Mascaro J, Wesselmann U, Schmidt E, Prost C, Callen J, Bröcker E, Diaz L, Giudice G.  Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180.  J Invest Dermatol.  1999 July. 113(1):117-21.
[Link]

Chimanovitch I, Schmidt E, Messer G, Döpp R, Partscht K, Bröcker E, Giudice G, Zillikens D.  IgG1 and IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis.  J Invest Dermatol.  1999 July. 113(1):140-2.
[Link]

Ding X, Diaz L, Fairley J, Giudice G, Liu Z.  The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic.  J Invest Dermatol.  1999 May. 112(5):739-43.
[Link]

Lin M, Gharia M, Swartz S, Diaz L, Giudice G.  Identification and characterization of epitopes recognized by T lymphocytes and autoantibodies from patients with herpes gestationis.  J Immunol.  1999 April 15. 162(8):4991-7.
[PubMed]

Zillikens D, Giudice G.  BP180/type XVII collagen: its role in acquired and inherited disorders or the dermal-epidermal junction.  Arch Dermatol Res.  1999 April. 291(4):187-94. Review.
[PubMed]

Schmidt E, Herzele K, Schumann H, Wesselmann U, Chimanovitch I, Bruckner-Tuderman L, Bröcker E, Giudice G, Zillikens D.  Linear IgA disease with circulating IgA antibodies against the NC16A domain of BP180.  Br J Dermatol.  1999 March. 140(5):964-6.
[Link]

Zillikens D, Giudice G.  BP180/type XVII collagen: Its role in acquired and inherited disorders of the dermal-epidermal junction.  Arch Dermatol Res.  1999. 

Seitz C, Giudice G, Balding S, Marinkovich M, Khavari P.  BP180 gene delivery in junctional epidermolysis bullosa.  Gene Ther.  1999 January. 6(1):42-7.
[Link]

Ishiko A, Shimizu H, Masunaga T, Yancey K, Giudice G, Zone J, Nishikawa T.  97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen.  J Invest Dermatol.  1998 July. 111(1):39-6.
[Link]

Murakami H, Nishioka S, Setterfield J, Bhogal B, Black M, Zillikens D, Yancey K, Balding S, Giudice G, Diaz L, Nishikawa T, Kiyokawa C, Hashimoto T.  Analysis of antigens targeted by circulating IgG and IgA autoantibodies in 50 patients with cicatricial pemphigoid.  J Dermatol Sci.  1998 May. 17(1):39-44.
[PubMed]

Eaton D, Diaz L, Hans-Filho G, Santos V, Aoki V, Friedman H, Rivitti E, Sampaio S, Gottlieb M, Giudice G, Lopez A, Cupp E.  Comparison of black fly species (Diptera: Simuliidae) on an Amerindian reservation with a high prevalence of fogo selvagem to neighboring disease-free sites in the State of Mato Grosso do Sul, Brazil. The Cooperative Group on Fogo Selvagem Research .  J Med Entomol.  1998 March. 35(2):120-31.
[PubMed]

Fairley J, Ding X, Guidice G, Diaz L.  Pemphigus foliaceus and pemphigus vulgaris.  Humana Press Inc Totowa NJ.  1998. 

Zillikens D, Mascaro J, Rose P, Liu Z, Ewing S, Caux F, Hoffman R, Diaz L, Giudice G.  A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid.  J Invest Dermatol.  1997 November. 109(5):679-83.
[Link]

España A, Diaz L, Mascaró Jr J, Giudice G, Fairley J, Till G, Liu Z.  Mechanisms of acantholysis in pemphigus foliaceus.  Clin Immunol Immunopathol.  1997 October. 85(1):83-9.
[PubMed]

Zillikens D, Rose P, Balding S, Liu Z, Olague-Marchan M, Diaz L, Giudice G.  Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies.  J Invest Dermatol.  1997 October. 109(4):573-9.
[Link]

Marinkovich M, Tran H, Rao S, Giudice G, Balding S, Jonkman M, Pas H, McGuire J, Herron G, Bruckner-Tuderman L.  LAD-1 is absent in a subset of junctional epidermolysis bullosa patients.  J Invest Dermatol.  1997 September. 109(3):356-9.
[Link]

Liu Z, Giudice G, Zhou X, Swartz S, Troy J, Fairley J, Till G, Diaz L.  A major role for neutrophils in experimental bullous pemphigoid.  J Clin Invest.  1997 September 1. 100(5):1256-63.
[Link]

Balding S, Diaz L, Giudice G.  A recombinant form of the human BP180 ectodomain forms a collagen-like homotrimeric complex.  Biochemistry.  1997 July 22. 36(29):8821-30.
[PubMed]

Bédane C, McMillan J, Balding S, Bernard P, Prost C, Bonnetblanc J, Diaz L, Eady R, Giudice G.  Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: evidence that BP180 spans the lamina lucida.  J Invest Dermatol.  1997 June. 108(6):901-7.
[Link]

Caux F, Giudice G, Diaz L, Fairley J.  Autoimmune subepithelial blistering diseases with ocular involvement.  WB Saunders Co Philadelphia PA.  1997 February. 17(1):139-59.

Hans-Fiho G, dos Santos V, Katayama J, Aoki V, Rivitti E, Sampaio S, Friedman H, Moraes J, Moraes M, Eaton D, Lopez A, Hoffman R, Fairley J, Giudice G, Diaz L.  An active focus of high prevalence of fogo selvagem on an Amerindian reservation in Brazil. Cooperative Group on Fogo Selvagem Research.  J Invest Dermatol.  1996 July. 107(1):68-75.
[Link]

Zillikens D, Kawahara Y, Ishiko A, Shimizu H, Mayer J, Rank C, Liu Z, Giudice G, Tran H, Marinkovich M, Bröcker E, Hashimoto T.  A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone.  J Invest Dermatol.  1996 March. 106(3):465-70.
[Link]

Liu Z, Haas A, Diaz L, Conrad C, Giudice G.  Characterization of a novel keratinocyte ubiquitin carrier protein.  J Biol Chem.  1996 February 2. 271(5):2817-22.
[PubMed]

Zillikens D, Giudice G, Diaz L.  Bullous pemphigoid: An autoimmune blistering disease of the elderly.  J Geriat Dermatol.  1996. 

Caux F, Giudice G, Diaz L, Fairley J.  Cicatricial pemphigoid.  J Geriat Dermatol.  1996. 

Diaz L, Espana-Alonso A, Fairley J, Giudice G, Mascaro Jr J, Liu Z.  Skin Diseases Autoantibodies.  Elsevier Science New York NY.  1996. 

Balding S, Prost C, Diaz L, Bernard P, Bedane C, Aberdam D, Giudice G.  Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain.  J Invest Dermatol.  1996 January. 106(1):141-6.
[Link]

Liu Z, Diaz L, Swartz S, Troy J, Fairley J, Giudice G.  Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid.  J Immunol.  1995 December 1. 155(11):54449-54.
[PubMed]

Fairley J, Heintz P, Neuburg M, Diaz L, Giudice G.  Expression pattern of the bullous pemphigoid-180 antigen in normal and neoplastic epithelia.  Br J Dermatol.  1995 September. 133(3):385-91.
[PubMed]

Pohla-Gubo G, Lazarova Z, Giudice G, Liebert M, Grassegger A, Hintner H, Yancey K.  Diminished expression of the extracellular domain of bullous pemphigoid antigen 2 (BPAG2) in the epidermal basement membrane of patients with generalized atrophic benign epidermolysis bullosa.  Exp Dermatol.  1995 August. 4(4 pt 1):199-206.
[PubMed]

Giudice G, Liu Z, Diaz L.  An animal model of bullous pemphigoid: what can it teach us?.  Proc Assoc Am Physicians.  1995 July. 107(2):237-41.
[PubMed]

Liu Z, Giudice G, Swartz S, Fairley J, Till G, Troy J, Diaz L.  The role of complement in experimental bullous pemphigoid.  J Clin Invest.  1995 April. 95(4):1539-44.
[Link]

Emery D, Diaz L, Fairley J, Lopez A, Taylor A, Giudice G.  Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1.  J Invest Dermatol.  1995 March. 104(3):323-8.
[Link]

Giudice G, Wilske K, Anhalt G, Fairley J, Taylor A, Emery D, Hofmann R, Diaz L,  .  Development of an ELISA to detect anti-BP180 autoantibodies in bullous pemphigoid and herpes gestationis.  J Invest Dermatol.  1994 June. 102(6):878-81.
[Link]

Olague-Alcala M, Giudice G, Diaz L.  Pemphigus foliaceus sera recognize an N-terminal fragment of bovine desmoglein 1.  J Invest Dermatol.  1994 June. 102(6):882-5.
[Link]

Ståhle-Bäckdahl M, Inoue M, Giudice G, Parks W.  92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen.  J Clin Invest.  1994 May. 93(5):2022-30.
[PubMed]

Syder A, Yu Q, Paller A, Giudice G, Pearson R, Fuchs E.  Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity.  J Clin Invest.  1994 April. 93(4):1533-42.
[Link]

Liu Z, Diaz L, Giudice G.  Autoimmune response against the bullous pemphigoid 180 autoantigen.  Dermatology.  1994. 189(suppl 1):34-7.
[PubMed]

Crosby D, Giudice G, Diaz L.  Bullous Pemphigoid.  JB Lippincott Co Philadelphia PA.  1994. 

Crosby D, Giudice G, Diaz L.  Cicatricial Pemphigoid.  JB Lippincott Co Philadelphia PA.  1994. 

Giudice G, Emery D, Zelickson B, Anhalt G, Diaz L,  .  Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain.  J Immunol.  1993 November 15. 151(10):5742-50.
[Link]

Liu Z, Diaz L, Troy J, Taylor A, Emery D, Fairley J, Giudice G.  A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180.  J Clin Invest.  1993 November. 92(5):2480-8.
[PubMed]

Giudice G, Diaz L.  New laboratory methods in the investigation of bullous disease.  Dermatol Clin.  1993 July. 11:419-427.
[PubMed]

Allen E, Giudice G, Diaz L.  Subclass reactivity of pemphigus foliaceus autoantibodies with recombinant human desmoglein.  J Invest Dermatol.  1993 May. 100(5):685-91.
[Link]

Mascaro J, Giudice G, Diaz L.  Desmosomes and hemidesmosomes in autoimmune blistering diseases.  Medicina Cutánea Ibero-Latino-Americana.  1993. 11:419-27.

Giudice G, Diaz L.  New laboratory methods in the investigation of bullous disease.  1993. 11(3):419-27.
[PubMed]

Copeland N, Gilbert D, Li K, Sawamura D, Giudice G, Chu M, Jenkins N, Uitto J.  Chromosomal localization of mouse bullous pemphigoid antigens. BPAG1 and BPAG2: identification of a new region of homology between mouse and human chromosomes.  Genomics.  1993 January. 15(1):180-1.
[PubMed]

Giudice G, Emery D, Diaz L.  Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180.  J Invest Dermatol.  1992 September. 99(3):243-50.
[Link]

Li K, Giudice G, Tamai K, Do H, Sawamura D, Diaz L, Uitto J.  Cloning of partial cDNA for mouse 180-kDa bullous pemphigoid antigen (BPAG2), a highly conserved collagenous protein of the cutaneous basement membrane zone.  J Invest Dermatol.  1992 September. 99(3):258-63.
[PubMed]

Liu Z, Diaz L, Haas A, Giudice G.  cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript.  J Biol Chem.  1992 August 5. 267(22):15829-35.
[PubMed]

Ryynänen M, Knowlton R, Kero M, Sawamura D, Li K, giudice G, Diaz L, Uitto J.  Bullous pemphigoid antigens (BPAGs): identification of RFLPs in human BPAG1 and BPAG2, and exclusion as candidate genes in a large kindred with dominant epidermolysis bullosa simplex.  Genomics.  1991 December. 11(4):1025-9.
[PubMed]

Li K, Sawamura D, Giudice G, Diaz L, Mattei M, Chu M, Uitto J.  Genomic organization of collagenous domains and chromosomal assignment of human 180-kDa bullous pemphigoid antigen-2, a novel collagen of stratified squamous epithelium.  J Biol Chem.  1991 December. 266(35):24064-9.
[PubMed]

Guidice G, Squiquera H, Elias P, Diaz L.  Identification of two collagen domains within the bullous pemphigoid autoantigen, BP180.  J Clin Invest.  1991 February. 87(2):734-8.
[Link]

Diaz L, Ratrie 3rd H, Saunders W, Futamura S, Squiquera H, Anhalt G, Giudice G.  Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome.  J Clin Invest.  1990 October. 86(4):1088-94.
[Link]

Giudice G, Fuchs E.  Vitamin A-mediated regulation of keratinocyte differentiation.  Elsevier Inc.  1990. 190:18-29.
[PubMed]

Lersch R, Stellmach V, Stocks C, Giudice G, Fuchs E.  Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.  Mol Cell Biol.  1989 September. 9(9):3685-97.
[PubMed]

Giudice G, Fuchs E.  The transfection of epidermal keratin genes into fibroblasts and simple epithelial cells: evidence for inducing a type I keratin by a type II gene.  Cell.  1987 February 13. 48(3):453-63.
[PubMed]

Fuchs E, Tyner A, Giudice G, Marchuk D, RayChaudhury A, Rosenberg M.  The human keratin genes and their differential expression.  Curr Top Dev Biol.  1987. 22:5-34.
[PubMed]

Steinberg M, Shida H, Giudice G, Shida M, Patel N, Blaschuk O.  On the molecular organization, diversity and functions of desmosomal proteins.  Ciba Found Symp.  1986. 125:3-25.
[PubMed]

Gorbsky G, Cohen S, Shida H, Giudice G, Steinberg M.  Isolation of the non-glycosylated proteins of desmosomes and immunolocalization of a third plaque protein: Desmoplakin III.  Proc Nat Acad.  1985 February 1. 82(3):810-814.
[PubMed]

Kreuger J, Carter D, Steinberg M, Giudice G.  Some pemphigus autoantibodies react with desmosomes.  Ann NY Acad Sci.  1985. 455(1):734-738.

Giudice G, Cohen S, Patel N, Steinburg M.  Immunological comparison of desmosomal components from several bovine tissues.  J Cell Biochem.  1984. 26(1):35-45.
[PubMed]

Date Last Modified: 09/18/2014 - 15:17:41