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Assistant Professor of Anatomy and Cell Biology
Office: 1-550 Bowen Science BuildingIowa City, IA 52242
Office Phone: 319-335-7763
Lab: 1-500 Bowen Science BuildingIowa City, IA 52242
Email: firstname.lastname@example.orgWeb: Tootle Lab WebsiteWeb: PubMed link to publications
BS, Microbiology, University of Maryland, College ParkPhD, Biology, Massachusetts Institute of Technology
Post Doctoral, Prostaglandin signaling, Carnegie Institution for Science, Department of Embryology
Biosciences Graduate ProgramDepartment of Anatomy and Cell Biology Graduate ProgramInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in Molecular and Cellular BiologyMedical Scientist Training Program
Prostaglandins are transiently acting lipid signals that are synthesized at their sites of action by cyclooxygenase (COX) enzymes, the targets of Aspirin and Advil, to mediate a variety of biological activities, including inflammation, sleep, reproduction, and cancer development. How do prostaglandins regulate these diverse, cellular events? To address this question we have developed Drosophila oogenesis as a new and powerful model for studying prostaglandin signaling. Using both pharmacology and genetics, we have discovered that prostaglandins mediate Drosophila follicle development, identified the Drosophila COX1 enzyme, Pxt, and revealed that genetic perturbation of prostaglandin signaling can be used to exam the function of prostaglandins. This research on prostaglandin signaling implicates it in modulating actin/membrane dynamics, cell migration, stem cell activity, and the timing of gene expression during Drosophila follicle development.
The lab is currently pursuing how prostaglandin signaling regulates actin dynamics and invasive cell migrations during Drosophila follicle development. By using a multifaceted experimental approach that combines Drosophila genetics, cell biology, live imaging, and biochemistry to we can begin to work out the mechanisms by which prostaglandins regulate these processes, and provide general insight into how prostaglandins regulate the cytoskeleton and migration at a cellular level. Such mechanisms of prostaglandin action are likely to be reutilized throughout development, including mediating the changes that occur during cancer progression and metastasis.
Using Drosophila we have identified a number of novel targets of prostaglandins. We are now extending our studies to use human breast cancer cell lines to determine whether these new prostaglandin targets are conserved and the roles of such targets in prostaglandin-dependent cancer development, migration, and invasion.
Holden Comprehensive Cancer Center
Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling.
Molecular Biology of the Cell.
2012 December. 23(23):4567-78.
Date Last Modified: 06/07/2014 -
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