Anatomy and Cell Biology

Adam Dupuy, PhD

Portrait

Associate Professor of Anatomy and Cell Biology
Associate Professor of Pathology

Contact Information

Primary Office: 1-400A BSB
Iowa City, IA 52242

Email: adam-dupuy@uiowa.edu
Web: PubMed link to publications

Education

BA, Central College , Pella , IA
Graduate Research Assistant, University of Minnesota Cancer Center
PhD, Molecular, Cellular, Developmental Biology and Genetics, University of Minnesota

Post Doctoral, Mouse Cancer Genetics, National Cancer Institute

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Anatomy and Cell Biology Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Medical Scientist Training Program

Research Summary

The goal of my current research is to understand the role that somatic mutation plays in all aspects of tumor biology. Much of our work has made use of the Sleeping Beauty (SB) transposon system to engineer mouse cancer models in which somatic mutations are generated by transposon insertions. We and our collaborators have recently described a variety of tumor models using the approach, and these studies have identified many novel candidate cancer genes. The current work in my laboratory focuses on the genetics of hepatocellular carcinoma and T-cell leukemia. In addition, we have ongoing collaborative efforts to develop SB models of ovarian and endometrial cancer. Future work in the lab will focus on using our mouse models to address relevant questions encountered by oncologists in the clinic (e.g. metastasis, drug resistance).

Date Last Modified: 08/13/2013 - 13:56:33