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Assistant Professor of Anatomy and Cell Biology
Office: 1-400 B BSB51 Newton RoadIowa City, IA 52242
Office Phone: 319-335-7741
BS, Medical Sciences, Gandhi Memorial National CollegeMS, Biochemistry, National Dairy Research InstitutePhD, Biotechnology, Institute of Microbial TechnologyPostdoctoral Fellow, Biochemistry & Molecular Biology, University of Nebraska Medical CenterPostdoctoral Fellow, Biochemistry & Molecular Biology, Mayo Clinic College of MedicineResearch Associate, Biochemistry & Molecular Biology, Mayo Clinic College of Medicine
Biosciences Graduate ProgramDepartment of Anatomy and Cell Biology Graduate ProgramInterdisciplinary Graduate Program in Molecular and Cellular BiologyMedical Scientist Training Program
"Studies in Choudhury laboratory are focused on elucidating the mechanisms of sorting and trafficking of lipids and proteins associated with glycosphingolipid enriched membranes (GEM) “membrane rafts” in endothelial cells.
Research on membrane rafts is entering an exciting phase and key to understanding raft function in human physiology as well as in development of human diseases. “Membrane rafts” are small, heterogeneous, highly dynamic sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. In addition to lipids, these domains are enriched in certain growth factor receptors, GPI-anchored proteins, Src family of kinases, and members of caveolin family. The lipid and protein composition of membrane rafts play a vital role in some of the fundamental cellular functions such as: endocytosis, cargo sorting, secretion, and membrane trafficking. Family of proteins such as Rab GTPases and SNAREs regulate intracellular vesicular trafficking and maintain composition of membrane rafts.
Our laboratory is studying sorting and trafficking of glycosphingolipid enriched membranes (GEM) “membrane rafts” in endothelial cells and role of such fundamental processes during angiogenesis. Angiogenesis is establishment of new vessels from preexisting vasculature. When such processes go awry they can lead to several malignant, inflammatory, and ischemic disorders. Syntaxin 6 (syn6; t-SNARE) is a vesicle fusion protein that mediates trans-Golgi or post-Golgi membrane fusion events. We found that in human fibroblasts, syn6 is required for the delivery of certain GEM components to the plasma membrane. We now seek to better understand such GEM transport mechanisms in endothelial cells in context to angiogenesis. Our long-term interest is to understand mechanisms of sorting and trafficking of GEM-components in endothelial cells and study their role in cellular dynamics. We use combination of state of the art live cell imaging, pharmacological and biochemical approaches, in vitro and in vivo model systems for our studies."
Date Last Modified: 08/07/2013 -
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