Psychiatry

John Wemmie, PhD, MD

Portrait

Mailing Address

Office: 3115 ML
Iowa City, IA 52242
Phone: +1 319 384 3173
Email: john-wemmie@uiowa.edu

Education

BA, Chemistry, Central College, Pella, IA, 1989
PhD, University of Iowa, Iowa City, IA, 1996
MD, University of Iowa, Iowa City, IA, 1996
Residency, Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, 2000

Appointments

Primary: Psychiatry
Secondary: Physiology & Biophysics, Neurosurgery

Center and Program Affiliations

  • Interdisciplinary Graduate Program in Neuroscience

Research Interests

Effects of brain pH on human fear conditioning and anxiety disorders Novel methods of monitoring brain pH, Integration of molecular models of brain function and cognitive neuroscience, Long-lasting effects of fetal programming on mouse models of anxiety and depression, Role of protons as neurotransmitters, Roles of Acid Sensing Ion Channels in brain function, Roles of Acid Sensing Ion Channels in neuron physiology, Roles of Acid Sensing Ion Channels in behavior

Publications

  • Vralsted, V C, Price, M P, Du, J, Schnizler, M, Wunsch, A M, Ziemann, A E, Welsh, M J, Wemmie, J A. Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Genes Brain Behav 10(4):444-50, 2011. [PubMed]
  • Tao, H, Manak, J, Sowers, L, Mei, X, Kiyonari, H, Abe, T, Dahdaleh, N, Yang, T, Wu, S, Chen, S, Fox, M, Gurnett, C, Montine, T, Bird, T, Shaffer, L, Rosenfeld, J, McConnell, J, Madan-Khetarpal, S, Berry-Kravis, E, Griesbach, H, Saneto, R, Scott, M, Antic, D, Reed, J, Boland, R, Ehaideb, S, El-Shanti, H, Mahajan, V, Ferguson, P, Axelrod, J, Lehesjoki, A, Fritzsch, B, Slusarski, D, Wemmie, J, Ueno, N, Bassuk, A. Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet 88(2):138-49, 2011. [PubMed]
  • Walder, R, Rasmussen, L, Rainier, J, Light, A, Wemmie, J, Sluka, K. ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. J Pain 11(3):210-8, 2010. [PubMed]
  • Ziemann, A, Allen, J, Dahdaleh, N, Drebot, I, Coryell, M, Wunsch, A, Lynch, C, Faraci, F, Howard, M, Welsh, M, Wemmie, J. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 139(5):1012-21, 2009. [PubMed]
  • Oya, H, Kawasaki, H, Dahdaleh, N, Wemmie, J, Howard, M. Stereotactic atlas-based depth electrode localization in the human amygdala. Stereotact Funct Neurosurg 87(4):219-28, 2009. [PubMed]
  • Coryell, M, Wunsch, A, Haenfler, J, Allen, J, Schnizler, M, Ziemann, A, Cook, M, Dunning, J, Price, M, Rainier, J, Liu, Z, Light, A, Langbehn, D, Wemmie, J. Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. J Neurosci 29(17):5381-8, 2009. [PubMed]
  • Zha, X, Wang, R, Collier, D, Snyder, P, Wemmie, J, Welsh, M. Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Proc Natl Acad Sci U S A 106(9):3573-8, 2009. [PubMed]
  • Schnizler, M, Schnizler, K, Zha, X, Hall, D, Wemmie, J, Hell, J, Welsh, M. The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction. J Biol Chem 284(5):2697-705, 2009. [PubMed]
  • Coryell, M, Wunsch, A, Haenfler, J, Allen, J, McBride, J, Davidson, B, Wemmie, J. Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses. J Neurosci 28(51):13738-41, 2008. [PubMed]
  • Ziemann, A, Schnizler, M, Albert, G, Severson, M, Howard, M, Welsh, M, Wemmie, J. Seizure termination by acidosis depends on ASIC1a. Nat Neurosci 11(7):816-22, 2008. [PubMed]