Pathology

Annette Schlueter, PhD, MD

Portrait

Mailing Address

Office: C250 GH
Iowa City, IA 52242
Phone: +1 319 356 0370
Email: annette-schlueter@uiowa.edu

Office/Lab Address

Office/Lab: SW234 GH
Iowa City IA, 52242
Phone: +1 319 335 7694

Web: Research Laboratory

Education

PhD, University of Illinois, 1991
MD, University of Illinois, 1993
Residency, Resident in Clinical Pathology, University of Iowa, 1996
Fellowship, Fellow in Transfusion Medicine, University of Iowa, 1998

Appointments

Primary: Pathology

Center and Program Affiliations

  • Interdisciplinary Graduate Program in Immunology

Research Interests

dendritic cell, ethanol, graft versus host disease, stem cell transplant

Research Summary

My laboratory is interested in the contributions of dendritic cell (DC) to disease. Specifically, we study the defects induced in DC by chronic ethanol (EtOH) exposure that contribute to increased incidence and severity of infectious disease, and the influence of aging on DC ability to induce more severe graft vs. host disease following allogeneic hematopoietic cell transplant (HCT). It is clear that chronic alcohol abuse results in immunodeficiency, characterized by increased risk and severity of multiple types of infection. Evidence from our mouse model of alcoholism indicates that chronic ethanol exposure results in decreased numbers of DC in peripheral lymphoid tissue and epidermis. In addition, we have found defective DC migration from skin to draining lymph nodes in the presence of EtOH. EtOH-exposed DC are also unable to present antigen appropriately to T cells, and have dysregulated costimulatory molecule expression. We are investigating additional ways in which EtOH exposure in vivo may influence DC function, thereby increasing the susceptibility of alcoholics to infection. In addition, my laboratory is interested in understanding the role that recipient DC play in the increased susceptibility of advanced age allogeneic HCT patients to graft-versus host disease (GVHD), and the mechanism(s) by which in vitro-derived recipient regulatory DC can control this disease. Understanding functional changes in these native and therapeutic populations with age will allow us to design therapeutic interventions that may limit the toxicity of GVHD, and allow this life-saving therapy to be offered to more advanced age patients.

Publications

  • Fan, J, Edsen-Moore, M, Turner, L, Cook, R, Legge, K, Waldschmidt, T, Schlueter, A. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res 35(1):47-59, 2011. [PubMed]
  • Chiang, H, Steelman, V, Pottinger, J, Schlueter, A, Diekema, D, Greenlee, J, Howard, M, Herwaldt, L. Clinical significance of positive cranial bone flap cultures and associated risk of surgical site infection after craniotomies or craniectomies. J Neurosurg 114(6):1746-54, 2011. [PubMed]
  • Bhatt, A, Neppalli, V, Kelley, E, Schlueter, A, Thomas, C. Dextran removal by plasmapheresis in a kidney-pancreas transplant recipient with dextran 40-induced osmotic nephrosis. Am J Kidney Dis 57(4):621-3, 2011. [PubMed]
  • Chitu, V, Ferguson, P, de Bruijn, R, Schlueter, A, Ochoa, L, Waldschmidt, T, Yeung, Y, Stanley, E. Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice. Blood 114(12):2497-505, 2009. [PubMed]
  • McGill, J, Meyerholz, D, Edsen-Moore, M, Young, B, Coleman, R, Schlueter, A, Waldschmidt, T, Cook, R, Legge, K. Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections. J Immunol 182(12):7803-8, 2009. [PubMed]
  • Alex, J, Bahl, M, Schlueter, A. Peripheral blood stem cell recovery following early termination of apheresis due to hypotension in a 4.8-kg infant. J Clin Apher 24(3):120-1, 2009. [PubMed]
  • Edsen-Moore, M, Fan, J, Ness, K, Marietta, J, Cook, R, Schlueter, A. Effects of chronic ethanol feeding on murine dendritic cell numbers, turnover rate, and dendropoiesis. Alcohol Clin Exp Res 32(7):1309-20, 2008. [PubMed]
  • Ness, K, Fan, J, Wilke, W, Coleman, R, Cook, R, Schlueter, A. Chronic ethanol consumption decreases murine Langerhans cell numbers and delays migration of Langerhans cells as well as dermal dendritic cells. Alcohol Clin Exp Res 32(4):657-68, 2008. [PubMed]
  • Goldman, F, Aubert, G, Klingelhutz, A, Hills, M, Cooper, S, Hamilton, W, Schlueter, A, Lambie, K, Eaves, C, Lansdorp, P. Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood 111(9):4523-31, 2008. [PubMed]
  • Cook, R, Schlueter, A, Coleman, R, Tygrett, L, Ballas, Z, Jerrells, T, Nashelsky, M, Ray, N, Haugen, T, Waldschmidt, T. Thymocytes, pre-B cells, and organ changes in a mouse model of chronic ethanol ingestion--absence of subset-specific glucocorticoid-induced immune cell loss. Alcohol Clin Exp Res 31(10):1746-58, 2007. [PubMed]