Pathology

Sergei Syrbu, MD, PhD

Portrait

Mailing Address

Office: 5338B RCP
Iowa City, IA 52242
Phone: +1 319 356 7372
Email: sergei-syrbu@uiowa.edu

Education

MD, State University of Medicine, Chishinau,, Moldova, 1982
PhD, All Union Cardiology Research Center, Moscow, USSR, 1987
Post-Doc, University of Connecticut Health Center, 1999
Residency, Pathology, University of Iowa Carver College of Medicine, 2003
Fellowship, Hematopathology, University of Iowa Carver College of Medicine, 2004

Appointments

Primary: Pathology

Research Interests

bone marrow pathology, immunohistochemistry, lymphoproliferative disorder, serologic examination of autoimmune process

Research Summary

Interests Include: Cytologic and histomorphologic correlations of bone marrow and lymph node biopsies with immunohistochemistry and flow cytometric analysis in hematopoietic disorders and lymphomas. Development of new monoclonal antibodies and antigen retrieval procedures for immunohistochemical staining of formalin-fixed, paraffin embedded tissues.

Publications

  • Maurer, M, Micallef, I, Cerhan, J, Katzmann, J, Link, B, Colgan, J, Habermann, T, Inwards, D, Markovic, S, Ansell, S, Porrata, L, Johnston, P, Nowakowski, G, Thompson, C, Gupta, M, Syrbu, S, Kurtin, P, Macon, W, Nikcevich, D, Witzig, T. Elevated serum free light chains are associated with event-free and overall survival in two independent cohorts of patients with diffuse large B-cell lymphoma. J Clin Oncol 29(12):1620-6, 2011. [PubMed]
  • Syrbu, S, Cohen, M. An enhanced antigen-retrieval protocol for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues. Methods Mol Biol 717:101-10, 2011. [PubMed]
  • Savage, E, Vanderheyden, A, Bell, A, Syrbu, S, Jensen, C. Independent diagnostic accuracy of flow cytometry obtained from fine-needle aspirates: a 10-year experience with 451 cases. Am J Clin Pathol 135(2):304-9, 2011. [PubMed]
  • Nasr MR, Syrbu SI.  CD15 expression in Hodgkin and Reed-Sternberg-like cells in lymph node: Pathologic significance and differential diagnosis.  ASCP Check Sample 46(1):1-8, 2011.
  • Bleile MJ, Syrbu SI.  Diffuse Large B-cell lymphoma, plasmablastic variant: Clinical features and pathologic diagnosis.  ASCP Check Sample 46(3):19-27, 2011.
  • Nasr, M, Rosenthal, N, Syrbu, S. Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker. Am J Clin Pathol 133(1):41-8, 2010. [PubMed]
  • Thomas, D, Syrbu, S, Graham, M. Epstein-Barr virus mimicking lymphoma on FDG-PET/CT. Clin Nucl Med 34(12):891-3, 2009. [PubMed]
  • Muirhead, D, Stone, M, Syrbu, S. The utility of PU.1 as an immunohistochemical marker for histiocytic and dendritic lesions of the skin. Am J Dermatopathol 31(5):432-5, 2009. [PubMed]
  • McCune, R, Syrbu, S, Vasef, M. Expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in Hodgkin's and non-Hodgkin's lymphomas: a comparative study using high throughput tissue microarrays. Mod Pathol 19(7):1010-8, 2006. [PubMed]
  • Rokhlin, O, Taghiyev, A, Guseva, N, Glover, R, Syrbu, S, Cohen, M. TRAIL-DISC formation is androgen-dependent in the human prostatic carcinoma cell line LNCaP. Cancer Biol Ther 1(6):631-7, 0. [PubMed]