Ophthalmology & Visual Sciences

Young Kwon, MD, PhD

Portrait

Mailing Address

Office: 11190B PFP
Iowa City, IA 52242
Phone: +1 319 356 3938
Email: young-kwon@uiowa.edu

Education

BS, Biology, Massachusetts Institute of Technology, Cambridge, Mass, 1984
MD, Yale University School of Medicine, New Haven, Conn, 1991
PhD, Neuroscience, Massachusetts Institute of Technology, Cambridge, Mass, 1991
Internship, Internal Medicine, Mt Auburn Hospital, Harvard Medical School, Cambridge, MA, 1992
Fellowship, Glaucoma, Yale University School of Medicine, New Haven, Conn, 1996

Appointments

Primary: Ophthalmology & Visual Sciences

Research Interests

glaucoma, optic disc image analysis, patient's guide to glaucama, pixel classification

Research Summary

Glaucoma is the second leading cause of blindness in the United States, but can be managed if diagnosed early and treated appropriately. Adequate diagnosis and treatment depends on measurement of changes in the optic nerve cupping. We have developed a novel computer software method to automatically measure the optic nerve changes from digital stereo optic nerve photographs. This image processing alogorithm is based on pixel feature classification algorithm, which has previously been developed for the purpose of evaluating diabetic retinopathy in digital fundus photographs. We have utilized novel, biologically plausible pixel feature classification algorithm to automatically segment the optic disc into cup and rim, and compared its performance to the reference standard, i.e., computer-assisted planimetry by human glaucoma experts. The early results are promising. We hope to eventually develop and refine the algorithm to objectively diagnose and detect progression of glaucomatous optic nerve cupping from serial digital stereo fundus photographs. Dr. Kwon is also interested in the education of public regarding glaucoma through free on- line publications. See www.medrounds.org/glaucoma-guide.

Publications

  • Analysis of ASB10 variants in open angle glaucoma. Hum Mol Genet 21(20) : 4543-8, 2012. [PubMed]
  • Distribution of damage to the entire retinal ganglion cell pathway: quantified using spectral-domain optical coherence tomography analysis in patients with glaucoma. Arch Ophthalmol 130(9) : 1118-26, 2012. [PubMed]
  • Glaucoma therapy escalation in eyes with pseudophakic corneal edema after penetrating keratoplasty and Descemet's stripping automated endothelial keratoplasty. Int Ophthalmol 32(1) : 9-14, 2012. [PubMed]
  • 2-D pattern of nerve fiber bundles in glaucoma emerging from spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci 53(1) : 483-9, 2012. [PubMed]
  • Localization of SH3PXD2B in human eyes and detection of rare variants in patients with anterior segment diseases and glaucoma. Mol Vis 18 : 705-13, 2012. [PubMed]
  • Robust multiscale stereo matching from fundus images with radiometric differences. IEEE Trans Pattern Anal Mach Intell 33(11) : 2245-58, 2011. [PubMed]
  • Automated 3-D method for the correction of axial artifacts in spectral-domain optical coherence tomography images. Biomed Opt Express 2(8) : 2403-16, 2011. [PubMed]
  • Heat transfer and pressure drop characteristics of nanofluids in a plate heat exchanger. J Nanosci Nanotechnol 11(7) : 5769-74, 2011. [PubMed]
  • Copy number variations on chromosome 12q14 in patients with normal tension glaucoma. Hum Mol Genet 20(12) : 2482-94, 2011. [PubMed]
  • Novel drug delivery systems for glaucoma. Eye (Lond) 25(5) : 578-86, 2011. [PubMed]