Microbiology

Martin Richer

Martin Richer

Postdoctoral Research Scholar
Address: 3-501B BSB
Phone: (319) 335-9919
Email: martin-richer@uiowa.edu

Mentor: John Harty, PhD

Undergraduate Institution: McGill University

PhD Institution: The University of British Columbia

Research Description

CD8 T cells play a critical role in the immune response to intracellular pathogens. Understanding the factors that regulate both the quantity and the quality of CD8 T cell responses to infection may have important implications for the development of cancer therapies and effective vaccines. I am currently interested in characterizing the effects of inflammatory cytokines on the quality of effector and memory CD8 T cell responses to viral and bacterial infections.

Publication(s)

Condotta SA, Richer MJ, Badovinac VB and Harty JT (2012) Probing CD8 T Cell Responses with Listeria monocytogenes Infection. Advances in Immunology (In press) Review.

Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. (2012) Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice. PLoS ONE (In press)

Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. (2009) Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. PLoS ONE. 2009;4(1):e4127.

Richer MJ, Straka N, Fang D, Shanina I and Horwitz MS (2008) Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta. Diabetes. 2008 May;57(5):1302-11.

Richer MJ, Fang D., Shanina I. and Horwitz MS. (2006) Toll-like Receptor 4-induced Cytokine Production Circumvents Protection Conferred by TGF-β in Coxsackievirus Mediated Autoimmune Myocarditis. Clinical Immunology. 121, (3), Dec 2006: 339-349.