Microbiology

Natalija Budimir, Ph.D.

Natalija Budimir

Postdoctoral Research Scholar
Address: 3-501 BSB
Phone: (319) 335-9919
Email: natalija-budimir@uiowa.edu

Mentor: John Harty, PhD

Year Entered Into Program: 2014

PhD Institution: University of Groningen

Research Description

My current research is focused on characterizing protective CD8 T cell response against liver-stage Plasmodium infections using mouse as a model system. Major focus points are:

  • Successful induction of memory CD8 T cell responses by prime-boost vaccination with subunit formulations
  • Dissecting numerical values required for protection
  • Influence of host background genes on CD8 T cell-mediated protection against Plasmodium infections¬†

Publication(s)

Budimir N, de Haan A, Meijerhof T, Gostick E, Price DA, Huckriede A, Wilschut. J. Heterosubtypic cross-protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration. Influenza Other Respir Viruses. 2013 Nov;7(6):1202-9. doi: 10.1111/irv.12142. Epub 2013 Sep 16. PubMed PMID: 24102979.

Budimir N, de Haan A, Meijerhof T, Waijer S, Boon L, Gostick E, Price DA, Wilschut J, Huckriede A. Critical role of TLR7 signaling in the priming of cross-protective cytotoxic T lymphocyte responses by a whole inactivated influenza virus vaccine. PLoS One. 2013 May 2;8(5):e63163. doi: 10.1371/journal.pone.0063163. Print 2013. PubMed PMID: 23658804; PubMed Central PMCID: PMC3642048.

Budimir N, Huckriede A, Meijerhof T, Boon L, Gostick E, Price DA, Wilschut J, de Haan A. Induction of heterosubtypic cross-protection against influenza by a whole inactivated virus vaccine: the role of viral membrane fusion activity. PLoS One. 2012;7(1):e30898. doi: 10.1371/journal.pone.0030898. Epub 2012 Jan 27. PubMed PMID: 22303469; PubMed Central PMCID: PMC3267744.

Budimir N, Meijerhof T, Wilschut J, Huckriede A, de Haan A. The role of membrane fusion activity of a whole inactivated influenza virus vaccine in (re)activation of influenza-specific cytotoxic T lymphocytes. Vaccine. 2010 Dec 6;28(52):8280-7. doi: 10.1016/j.vaccine.2010.10.007. Epub 2010 Oct 19. PubMed PMID: 20965298.