Microbiology

Nicholas Lennemann

Nicholas Lennemann

Address: 3-701E BSB
Phone: (319) 335-7613
Email: nicholas-lennemann@uiowa.edu

Mentor: Wendy J. Maury, PhD

Undergraduate Institution: Saint Cloud University

Research Description

I am interested in characterizing how filoviral glycoproteins interact with the host cell. Filoviruses, Ebolavirus and Marburgvirus, express a single, heavily glycosylated, surface glycoprotein (GP) that mediates receptor interaction and membrane fusion. One goal of my research project is to identify the specific residues, within the receptor-binding domain (RBD) of GP, that interact with a host cell surface receptor that our lab has identified, TIM-1. Another aspect of my research is to examine the role of N-linked glycans on GP, which mask the RBD, during the Ebolavirus entry process. Information gathered from these studies can be used for downstream applications such as the development of antivirals, vaccine strategies, and gene therapy.

Publication(s)

Fischer, A.J., N.J. Lennemann, S. Krishnamurthy, P. Pocza, L. Durairaj, J.L. Launspach, B.A. Rhein, C. Wohlford-Lenane, D. Lorentzen, B. Banfi, and P.B. McCray, Jr. 2011. Enhancement of respiratory mucosal anti-viral defenses by iodide oxidation. Am J Respir Cell Mol Biol 45:874-81.

Kondratowicz, A.S., N.J. Lennemann, P.L. Sinn, R.A. Davey, C.L. Hunt, S. Moller-Tank, D.K. Meyerholz, P. Rennert, R.F. Mullins, M. Brindley, L.M. Sandersfeld, K. Quinn, M. Weller, P.B. McCray, Jr., J. Chiorini, and W. Maury. 2011. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A 108: 8426-31.

Award(s)

  • Member, UI Virology Training Program, 2009-2001 (NIH T32 AI007533)