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Address: 540 EMRB
Phone: (319) 335-8666
Mentor: Timothy L. Yahr, PhD
Undergraduate Institution: St. Joseph's College, Bangalore, India
Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen commonly found in soil and water. Due to its opportunistic nature, it is primarily of major concern in patients receiving critical care or suffering from severe burns, cystic fibrosis, AIDS and cancer. It has become the most important pathogen in cystic fibrosis (CF) patients. This pathogen displays a plethora of virulence factors including a large number of secreted toxins and surface associated components. In bacteria, gene expression is regulated at various levels. RsmA/CsrA, a family of RNA binding proteins, exerts post- transcriptional control in various bacteria. Previous studies of P. aeruginosa have shown that RsmA exerts negative and positive post- transcriptional control on a broad range of downstream target genes by either stabilizing or destabilizing the mRNAs. My current goal includes deciphering the role of RsmA as a direct activator of integral components of the T3SS. Our long term goal is to gain an in depth understanding of the complex virulence regulon present in P. aeruginosa.
Diaz, M.R., King, J.M., Yahr, T.L. 2011. Intrinsic and Extrinsic Regulation of Type III Secretion Gene Expression in Pseudomonas aeruginosa. Front Microbiol. 2:89.
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