Microbiology

Brouillette, Rachel

Rachel Brouillette

Address: 3-701E
Phone: (319) 335-7613
Email: rachel-brouillette@uiowa.edu

Mentor: Wendy J. Maury, PhD

Undergraduate Institution: Iowa State University

Research Description

I study cellular entry mechanisms of arenaviruses such as Machupo and Lassa viruses. Mostly, I am working to define the roles of N-linked glycans present on the New World arenavirus glycoprotein complexes that coat the viral envelopes and are directly recognized for receptor-mediated endocytosis. I am interested in learning the importance of these glycans in protein expression, proteolytic processing and transport as well as receptor binding and fusion with the host membrane.

Publication(s)

Eum, J.-H.; R.C. Bottjen; A.J. Pruijssers; K.D. Clark; M.R. Strand. (2010). "Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus." Insect Biochemistry and Molecular Biology 40(9): 690-698. 

Bassuk, AG; Muthuswamy, LB; Boland, R; Smith, TL; Hulstrand, AM; Northrup, H; Hakeman, M; Dierdorff, JM; Yung, CK; Long, A; Brouillette, RB; Au, KS; Gurnett, C; Houston, DW; Cornell, RA and Manak, JR. Copy number variation analysis implicates the cell polarity gene glypican 5 as a human spina bifida candidate gene Hum. Mol. Genet. (2013) 22 (6): 1097-1111. 

Award(s)

  • MS Student of the Year, Department of Entomology, University of Georgia, 2011