Cardiothoracic Surgery

  • Research

    Kal Parekh in LabResearch is an important part of the daily activities of all academic surgeons. The continuing commitment to productive scholarship, exemplified by research, as much as a commitment to communicative scholarship, exemplified by teaching, distinguishes the academic surgeon from his/her colleague in nonacademic practice.

    The obvious benefit of research to our patients and to the community is improved care. Less obvious, but equally important, benefits are the atmosphere of open and rigorous inquiry, the constant questioning and the intellectual stimulation which the research programs provide to their participants-faculty, residents and medical students.

    Peter J. Gruber, MD, PhD

    Clinical Projects

    • Hypoplastic left heart syndrome- genetic determinants of clinical outcomes
    • Transposition of the great arteries- genetic determinants of clinical outcomes
    • Pulmonary vein stenosis- genetic determinants of clinical outcomes
    • Histone deacetylase (HDAC) mediated protection of ischemia-repercussion injury
    • Congenital Heart Surgeons Society Registry of Biobanks

    Basic Science Projects

    Kalpaj R. Parekh, MD

    Chronic rejection in lung transplantation

    Clinical Projects

    • Randomized placebo controlled trial of anti T-lymphocyte immune globulin in the prophylaxis of acute pulmonary allograft rejection in adult recipients of primary pulmonary allografts
    • Utility of barium swallow in detecting clinically significant anastomotic leaks following esophagectomy

    Basic Science Projects

    • Development of an animal model for chronic rejection and cystic fibrosis in lung transplantation
    • Role of epithelial stem cells in lung transplantation (K08 awarded by NIH)

    Joseph W. Turek, MD, PhD

    Clinical Projects (Retrospective Reviews):

    • Beating-heart Norwood operation
    • Minimally invasive anomalous coronary artery repair
    • ECMO initiation Kaizen
    • Influence of bovine aortic arch on re-coarctation
    • Preoperative evaluation for pectus excavatum

    Basic Science Projects

    • Multi-level interactions between calcium/calmodulin-dependent protein kinase II and transient receptor potential vanilloid I regulate oxidation-mediated aortic aneurysm progression in Marfan syndrome