Porcine CH Nomenclature [ 13-11-02]
| Current Designation | Chain & Allotype | Gene | Serological Allele | Sequence Allele | GenBank Acc. # | Major Features and Other Information |
| IgG1 | γ1 | IGHG1 | U03778 | |||
| IgG2a | γ2a | IGHG2 | G2 * 01 | U03779 | Allotypic differences confirmed to Cγ1 domain. Differences from IgG1 throughout the sequence. | |
| IgG2b | γ2b | IGHG2 | G2 * 02 | U03780 | ||
| IgG3 | γ3 | IGHG3 | U03781 | Near identity to IgG1 in Cγ1, hinge and Cγ2. Five aa differences in Cγ3. | ||
| IgG4 | γ4 | IGHG4 | U03782 | Similar to IgG2 in hinge, and Cγ2. Differs from IgG2 in Cγ3 domain. | ||
| IgA | α | IGHA | Aa
Ab |
A + 01
A + 02 |
U12594
|
Splice acceptor site mutation in IgAb results in four aa reduction in the hinge. |
| IgM | μ | IGHM | U50148 | |||
| IgE | ε | IGHE | U96100 | |||
| IgD | δ | IGHD | µCH1 like δCH1, short hinge |
References
Kacskovics, I., J. Sun and J. E. Butler. 1994. Five putative subclasses of swine IgG identified from cDNA sequences of a single animal. J. Immunol. 153:3565-3573.
Kaltreider, H. B., and J. S. Johnson. 1972. Porcine immunoglobulins. I. Identification of subclass and preapration of specific antisera. J. Immunol. 109:992-998.
Brown, W. R., and J. E. Butler. 1994. Characterization of a Ca gene of swine. Mol. Immunol. 31:633-642.
Sun J., and J. E. Butler. 1997. Sequence analysis of pig switch m, Cm and Cmm. Immunogenetics 46:452-460.
Brown, W. R., I. Kacskovics, B. Amendt, R. Shinde, N. Bllackmore, M. Rothschild and J. E. Butler. 1995. The hinge deletion variant of porcine IgA results from a mutation at the splice acceptor site in the first Ca intron. J. Immunol. 154:3836-3842.
Butler, J. E., J. Sun and P. Navarro. 1996. The swine immunoglobulin heavy chain locus has a single JH and no identifiable IgD. International Immunology 8:1897-1904.
Bosch, B. L., K. D. Beaman and Y. B. Kim. 1992. Characterization of a cDNA clone encoding for a porcine immunoglobulin m chain. Dev. Comp. Immunol. 16:329-337.
Vernersson, M. P., T. Kistersson, K. Alving and L. Helleman. 1997. Cloning, structural analysis and expression of pig IgE e chain. Immunogenetics 46:461-468.
Porcine VH Nomenclature
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Porcine Vκ Genes
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Alignment of the Jκ gene segments of swine with those available for other common mammals
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