Biosciences Program Faculty performing Cancer Biology research

For additional information regarding cancer research at the University of Iowa, please visit the Holden Comprehensive Cancer Center.

Cancer research activities at The University of Iowa include basic and translational interdisciplinary programs that span all of the PhD programs and departments in the Biosciences Program. The cancer programs that include potential areas for graduate student include the following:

Cancer Epidemiology
Focuses on cancer etiology, cancer health services outcomes, oral health and cancer prevention and control.

Cellular Activation in Cancer
Investigative studies of cellular oncogene/tumor suppressor products, basic signaling mechanisms regulating cell growth and activation, and clinically-related cellular activation studies.

Experimental Therapeutics
Includes investigators with expertise in Developmental Pharmacology who are developing new therapeutic agents based on our growing knowledge of cell cycle control and signaling. Members of the program have expertise in tumor immunology including those who participate in the Lymphoma Specialized Program of Research Excellence (SPORE).

Free Radicals and Membranes
Discovered that model turmors transfected with superoxide dismutase demonstrate decreased turmor growth, and this is synergistic with an anticancer durg.

Molecular and Tumor Virology
Conducts research on the molecular mechanisms of interactions between viral and cellular gene products that influence viral replication, cell cycle, and cell division, host-virus, interactions at the level of virus entry, persistence, immuno response, and molecular epidemiology of viral disease.

Molecular Mechanisms of Metastasis
Focuses on the identification of genes underlying tumor progression and metastasis, including the molecular signature of turmor cells and the development of blood supplies for tumor growth.

Prostate Cancer Research
Studies the use of vaccine immunotherapy for prostate cancer, the identification of biomarkers during neoplastic progression, the application of innovative imaging, and apoptosis.

Name

Rank

Department/
Program
Research Description
Bickenbach, Jackie, PhD Professor Anatomy & Cell Biology
Dermatology
Pathology
Genetics
Molecular & Cellular Biology
Activation of embryonic transcription factors in epidermal stem cells and the dynamics of dedifferentiation in cancer biology and wound healing
Bishop, Gail, PhD Professor Microbiology
Internal Medicine
Immunology
Molecular & Cellular Biology
Molecular mechanisms of lymphocyte activation; role in normal immunity, autoimmunity, and lymphoma.
Brenner, Charles, PhD Professor (Head) Biochemistry
Molecular & Cellular Biology
Tumor suppressor gene function and NAD metabolism
Chen, Songhai, MD/PhD Assistant Professor Pharmacology
G protein-dependent signaling mechanisms of leukocyte migration and tumor metastasis
Choudhury, Amit, PhD Assistant Professor Anatomy & Cell Biology
Molecular mechanisms of sorting and trafficking of lipids and proteins associated with “membrane rafts” in normal and pathophysiological angiogenesis
Cohen, Michael, MD Professor Pathology
Urology
Epidemiology
Molecular & Cellular Biology
Receptor-ligand-mediated cell death in prostate cancer
Cornell, Robert, PhD Associate Professor Anatomy & Cell Biology
Genetics
Neuroscience
Molecular genetics of neural crest development in zebrafish
DeMali, Kris, PhD Assistant Professor Biochemistry
Molecular & Cellular Biology
Cellular mechanisms involved in assembly and maintenance of cell-cell adhesions by examining the function and regulation of proteins recruited to the cytoplasmic face of cadherins
Denburg, Natalie, PhD Assistant Professor Neurology
Neuroscience
Study of developmental changes in cognition
Domann, Frederick, PhD Professor Radiation Oncology
Free Radical & Radiation Biology
Human Toxicology
Molecular & Cellular Biology
DNA methylation and oncogenes, Ras and Cancer, Redox regulation of AP-2
Dupuy, Adam, PhD Assistant Professor Anatomy & Cell Biology
Genetics
Molecular & Cellular Biology
Developing new mouse models of human cancer using the Sleeping Beauty transposon system
Fisher, Rory, PhD Professor Pharmacology
Molecular & Cellular Biology
Siganal transduction of G protein-coupled receptors and RGS proteins
Fuentes, Ernesto, PhD Assistant Professor Biochemistry
Center for Biocatalysis & Bioprocessing
Training Program in the Pharmacological Sciences
Molecular & Cellular Biology
Molecular mechanisms governing specific signal transduction pathways
Giangrande, Paloma, PhD Assistant Professor Internal Medicine
Molecular & Cellular Biology
Developing RNA-based therapeutics to modulate cellular pathways underlying pathological cell proliferation in the setting of cancer and cardiovascular disease.
Goel, Apollina, PhD Assistant Professor Radiation Oncology
Free Radical & Radiation Biology
Chemo-radiotherapy for hematological malignancies. Understanding and circumventing therapy-resistance in multiple myeloma.
Goswami, Prabhat, PhD Associate Professor Radiation Oncology
Free Radical & Radiation Biology
Human Toxicology
Molecular & Cellular Biology
Intracellular Redox Environment and the Mammalian Cell Cycle
Griffith, Thomas, MD Associate Professor Urology
Immunology
Apoptosis, tumor immunology, urological oncology
Habelhah, Hasem, PhD Assistant Professor Pathology
Molecular & Cellular Biology
The role of TRAF2 phosphorylation in NF-?B activation and cancer cell resistance to apoptosis
Heidger, Paul, PhD Professor Anatomy & Cell Biology
Cell biology of the prostate gland and the tumor cell biology of prostatic adenocarcinoma
Henry, Michael, PhD Associate Professor Molecular Physiology & Biophysics
Pathology
Molecular and cellular biology underlying cancer metastasis
Heusel, Jonathan, MD/PhD Assistant Professor Pathology
Immunology
Molecular parameters of natural killer (NK) cell activation in the settings of viral infection, cancer, and allogeneic hematopoietic stem cell transplantation
Hohl, Raymond, MD/PhD Professor Internal Medicine
Pharmacology
Molecular & Cellular Biology
Role of Isoprene Compounds in Cell Proliferation and Differentiation
Houtman, Jon, PhD Assistant Professor Microbiology
Immunology
Molecular & Cellular Biology
Role of Adaptor Proteins in T Cell Activation
Ianzini, Fiorenza, PhD Assistant Professor Pathology
Radiation Oncology and Biomedical Engineering
Free Radical & Radiation Biology
Molecular Regulators of Cell Cycle Progression and Radiation- and Anticancer Drug-Induced Mitotic Catastrophe in Cancer Promotion and Progression
Janz, Siegfried, MD Professor Pathology
Immunology
Mouse models of human B cell and plasma cell neoplasms
Klingelhutz, Al, PhD Associate Professor Microbiology
Free Radical & Radiation Biology
Genetics
Molecular & Cellular Biology
Mechanisms of cellular immortalization and transformation by human papillomavirus
Knudson, C. Michael, MD/PhD Associate Professor Pathology
Free Radical & Radiation Biology
Molecular & Cellular Biology
Regulation of oncogenesis and cell death by the Bcl-2 family
Koland, John, PhD Associate Professor Pharmacology
Molecular & Cellular Biology
Signal Transduction by Growth Factor Receptor / Protein Tyrosine Kinases
Kuwana, Tomomi, PhD Assistant Professor Pathology
Molecular & Cellular Biology
Mitochondrial regulation of apoptosis
Leslie, Kimberly, MD Professor (Head) Obstetrics & Gynecology
Molecular & Cellular Biology
The molecular biology of estrogen and progesterone receptors, the effects of antiestrogens in the female reproductive tract, endometrial cancer, interactions between epidermal growth factor and hormone receptors.
Levasseur, Dana, PhD Assistant Professor Internal Medicine
Molecular & Cellular Biology
Transcriptional and epigenetic regulation of embryonic stem cell function and pluripotent stem cell biology
Ludewig, Gabriele, PhD Associate Professor Occupational & Environmental Health
Human Toxicology
Environmental Toxicology, Genetic Toxicology
Manak, John, PhD Assistant Professor Biology
Genetics
Genomics. Specifically, the study of a set of genes that have homologies to human genes involved in disease and cancer
Morita, Craig T., MD/PhD Associate Professor Internal Medicine
Immunology
Molecular & Cellular Biology
Nonpeptide antigen recognition by gamma-delta T cells
Motto, David, MD/PhD Assistant Professor Internal Medicine
Molecular & Cellular Biology
mechanisms of hemostasis and thrombosis (blood clotting)
Nagy, Peter, MD/PhD Assistant Professor Pathology
Biochemistry
Genetics
Histone methylation
O'Dorisio, Sue, MD/PhD Professor Pediatrics
Neuroscience
Molecularly targeted cancer imaging and therapy. Neuropeptides that modulate neurotransmission and provide neuroprotection.
Patil, Shivanand, PhD Professor Pediatrics
Genetics
Cytogenetic abnormalities in humans
Piper, Robert, PhD Professor Molecular Physiology & Biophysics
Genetics
Mechanisms governing the movement of proteins in eukaryotes
Quelle, Dawn, PhD Associate Professor Pharmacology
Molecular & Cellular Biology
Signaling pathways activated by the ARF & p53 tumor suppressors; molecular control of growth
Quelle, Frederick, PhD Associate Professor Pharmacology
Immunology
Cytokine receptor signal transduction mechanisms regulating cell growth and survival
Robertson, Larry, PhD Professor Occupational & Environmental Health
Free Radical & Radiation Biology
Human Toxicology
Mechanism(s) of toxicity of polyhalogenated aromatic hydrocarbons
Rothman, Paul, MD Professor (Head) Internal Medicine
Microbiology
Molecular Physiology & Biophysics
Immunology
Regulation of Cytokine Signaling
Sheff, David, MD/PhD Assistant Professor Pharmacology
Molecular & Cellular Biology
Intracellular Membrane Traffic and Receptor Sorting in the Endosomal System
Slusarski, Diane, PhD Associate Professor Biology
Genetics
Signal transduction mechanisms in development and disease
Spitz, Douglas, PhD Professor Radiation Oncology
Free Radical & Radiation Biology
Human Toxicology
Redox regulation of signal transduction and gene expression, oxidative stress responses, mitochondrial free radical production, and aging.
Stamnes, Mark, PhD Associate Professor Molecular Physiology & Biophysics
Molecular & Cellular Biology
Molecular mechanisms of intracellular protein transport and sorting in the mammalian Golgi apparatus
Stipp, Christopher, PhD Assistant Professor Biology
Molecular Physiology and Biophysics
Neuroscience
Functions of cell surface receptor complexes in tumor cell migration; cell-extracellular matrix interactions; neurite outgrowth and neuronal growth cone motility
Tan, Kai, PhD Assistant Professor Internal Medicine
Biomedical Engineering
Genetics
Understanding gene regulatory networks and molecular pathways in human diseases
Wallrath, Lori, PhD Professor Biochemistry
Genetics
Molecular & Cellular Biology
The role of chromatin proteins in disease
Washington, M. Todd, PhD Associate Professor Biochemistry
Molecular & Cellular Biology
Understanding the mechanisms of DNA polymerases involved in both mutagenic and error-free replication of DNA damage at the thermodynamic, kinetic, and structural level
Weiner, George, MD Professor Internal Medicine
Immunology
Lymphoma and leukemia immunotherapy; Mechanisms of action of anti-tumor monoclonal antibodies
Wold, Marc, PhD Professor Biochemistry
Molecular & Cellular Biology
Molecular mechanisms of eukaryotic chromosomal DNA replication
Wright, Michael, PhD Assistant Professor Molecular Physiology & Biophysics
Using quantitative proteomic approaches to build quantitative models of signal transduction.
Yeaman, Charles, PhD Associate Professor Anatomy & Cell Biology
Molecular & Cellular Biology
Cell mechanisms involved in development and maintenance of epithelial cell polarity

 
 

 

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