Weizhou Zhang Laboratory—Department of Pathology

  • Selected Publications

    1. Pablo López-Bergami, Hasem Habelhah, Anindita Bhoumik, Weizhou Zhang, Lu-Hai Wang, and Ze’ev Ronai. Receptor For Activated C Kinase 1 mediates activation of Jun N-terminal Kinase by Protein Kinase C. Molecular Cell. 2005, Aug 5;19(3):309-20. PMID: 16061178; PMCID: PMC2953422. Impact factor: 14.971 [PubMed]
    2. Weizhou Zhang, Cong S. Zong, Ulrich Hermanto, Pablo Lopez-Bergami, Ze’ev Ronai and Lu-Hai Wang. RACK1 Recruits STAT3 Specifically to Insulin and IGF-1 Receptors for Activation, Which Is Important for Regulating Anoikis and Anchorage Independent Growth. Molecular and Cellular Biology. 2006, Jan; 26(2):413-24. PMID: 16382134; PMCID: PMC1346890. Impact factor: 6.773 [PubMed]
    3. George Z. Cheng, Joseph Chan, Calvin D. Sun, Qi Wang, Weizhou Zhang and Lu-Hai Wang. Twist transcriptionally upregulates AKT2 in breast cancer cells leading to increased migration, invasion and resistance to paclitaxel. Cancer Research. 2007, Mar 1;67(5):1979-87. PMID: 17332325. Impact factor: 8.036 [PubMed]
    4. Kathryn Masker, Alicia Golden, Christian J. Gaffney, Virginia Mazack, William F. Schwindinger, Weizhou Zhang, Lu-Hai Wang, David J. Carey, Marius Sudol. Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src. Virology. 2007, 364(1): 10-20. PMID: 17448514; PMCID: PMC1974879. Impact factor: 3.357 [PubMed]
    5. George Cheng*, Weizhou Zhang*, Lu-Hai Wang. Regulation of cancer cell survival, migration and invasion by TWIST : AKT2 comes to interplay. Cancer Research. 2008, Feb 15;68(4):957-60. (* equal contribution). PMID: 18281467. Impact factor: 8.036 [PubMed]
    6. George Z. Cheng*, Weizhou Zhang*, Sun M, Qi Wang, Coppola D, Costanzo C, Xu LM, Joseph Chan, Jinquan Cheng, Lu-Hai Wang. Twist is Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. Journal of Biological Chemistry. 2008, Mar. 283(21): 14665-14673 (* equal contribution). PMID: 18353781; PMCID: PMC2386910. Impact factor: 5.575 [PubMed]
    7. George Z. Cheng, Sungman Park, Shaokun Shu, Lili He, William Kong, Weizhou Zhang, Zengqiang Yuan, Lu-Hai Wang, Jin Q. Cheng. Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery. Current Cancer Drug Targets, 2008, Feb;8(1):2-6. PMID: 18288938. Impact factor: 4.316 [PubMed]
    8. Weizhou Zhang*, George Z. Cheng*, Ulrick Hermanto, Cong S. Zong, Jin Q. Cheng and Lu-Hai Wang. RACK1 and CIS mediates the degradation of BimEL in cancer cells. Journal of Biological Chemistry. 2008, Apr; 283(4): 16416-16426. (* equal contribution). PMID: 18420585; PMCID: PMC2423247. Impact factor: 5.575 [PubMed]
    9. Atsushi Matsuzawa, Ping-Hui Tseng, Ewen Gallagher, Jun-Li Luo, Weizhou Zhang, Sivakumar Vallabhapurapu, Michael Karin. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science, 2008, 321(5889):663-8. PMID: 18635759; PMCID: PMC2669719. Impact factor: 30.268 [PubMed]
    10. Sivakumar Vallabhapurapu, Atsushi Matsuzawa, Weizhou Zhang, Ping-Hui Tseng, Jonathan J. Keats, P. Leif Bergsagel and Michael Karin. TRAF2 and TRAF3 carry out non-redundant and complementary functions to activate IKK-dependent alternative NF-κB signaling. Nature Immunology. 2008, 9(12):1364-70. PMID: 18997792; PMCID: PMC2671996. Impact factor: 26.247 [PubMed]
    11. Thomas Enzler*, Arnon P. Kater*, Weizhou Zhang*, George F. Widhopf II, Han-Yu Chuang, Jason Lee, Esther Avery, Carlo M. Croce, Michael Karin, Thomas J. Kipps. Chronic B-Cell leukemia of Eµ-TCL1 transgenic mice undergoes rapidcell-turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 2009, 114(20):4469-76 (* equal contribution). PMID: 19755673. Impact factor: 9.900. [PubMed]
    12. Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A. Vignali, Michale Karin. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nature Immunology. 2010, Jan;11(1):70-5. PMID: 19898473; PMCID: PMC2872790. Impact factor: 25.668 [PubMed]
    13. Weizhou Zhang*, Arnon P. Kater*, Han-Yu Chuang, Thomas Enzler, George F. Widhopf II, Danelle F. James, Ping-Hui Tseng, Carl Hoh, Harvey Herschman, Thomas J. Kipps, Michael Karin. B cell activating factor and c-Myc regulate progression of B cell chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 2010, Nov 2;107(44):18956-60. PMID: 20956327; PMCID: PMC2973856. Impact factor: 10.591 [PubMed]
    14. Seong Deok Kong, Weizhou Zhang, Jun Hee Lee, Karla Brammer, Ratnesh Lal, Michael Karin, Sungho Jin. Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release. Nano Letters. 2010, Nov 1;10: 5088–92. PMID: 21038917. Impact factor: 12.832. [PubMed]
    15. Wei Tan*, Weizhou Zhang*, Amy Strasner, Sergei Grivennikov, Robert M. Hoffman, Jin Q. Cheng, Michael Karin. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011, Feb 24;470(7335):548-53. (*equal contribution) PMID: 21326202; PMCID: PMC3166217. Impact factor: 36.235 [PubMed]
    16. Seong Deok Kong, Marta Sartor, Che-Ming Jack Hu, Weizhou Zhang, Liangfang Zhang, Sungho Jin. Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release. Acta Biomater. 2012, S1742-7061(12) 00545-4. PMID: 23149252. Impact factor: 5.076. [PubMed]
    17. Di Guan, Weiqi Zhang, Weizhou Zhang, Guang-Hui Liu, Juan Carlos Izpisua Belmonte. Switching cell fate, ncRNAs coming to play. Cell Death Dis. 2013 Jan 17;4:e464. PMID: 23328671; PMCID: PMC3563984. Impact factor: 5.333. [PubMed]
    18. Weizhou Zhang, Wei Tan, Xuefeng Wu, Maxim Poustovoitov, Amy Strasner, Wei Li, Majid Ghassemian, Andrew Koff, and Michael Karin. A NIK-IKKα module promotes ErbB2-induced mammary tumorigenesis and tumor initiating cellexpansion by stimulating nuclear export of tumor suppressor p27/Kip1. 2013. Cancer Cell. In press. Impact factor: 28.175

    See complete list at [PubMed]