• Advanced Problem Solving in Pharmacological Sciences

    Course Offering: Fall and Spring Annually

    Course Co-Coordinators: Associate Professor Dawn Quelle and Professor David Roman

    Credits: 1 credit

    Grading: S/U

    This is a required course for all students supported on the Pharmacological Sciences Training Grant. The primary goal of this course is to expose students to a broad range of scientific expertise and experimental designs, to develop interpersonal problem solving skills, and to propose plans of study for solving contemporary scientific problems in the Pharmacological Sciences.

    The course will meet once a month on the first Thursday of the month in 2-332 BSB from 5:00 - 6:00pm. The faculty host will provide a one hour presentation to the students and provide an appropriate handout. The subject of each presentation will involve some methodology, strategy, or approach commonly used to solve problems in the pharmacological sciences. The format will include examples of how the method, strategy or approach has been successfully used to derive scientific information and to advance knowledge in the pharmacological sciences. The faculty host will provide students with one significant unsolved problem to serve as the format for a group thought experiment to be completed independently.

    The students will be required to meet at least three times per month outside of class to discuss possible solutions to the problem posed to them. The students must work collaboratively to bring together their combined expertise and background to shape a "Plan of Study" (described below) that will be submitted to the faculty host in response to the problem posed. The students should not feel limited to using methodology or strategies that were presented in that session, but should look at this as a cumulative exercise that may include any and all methods, strategies and approaches to propose solutions to the problem. A selected student correspondent will be responsible for organizing the outside class discussions and to prepare and submit the Plan of Study. The faculty host will critique the Plan of Study and provide written feedback to the group.

    One of the primary goals of this class is to bring together interdisciplinary scientists to work together to design a collaborative plan of study, to communicate and share ideas, and to propose workable solutions to contemporary problems in the Pharmacological Sciences. Students supported on the training grant must select this course for 4 semesters, resulting in exposure to 14 faculty and numerous peers in the Pharmacological Sciences.

    Composition of the Plan of Study

    The report should be prepared in Word to be e-mailed to the faculty host, three weeks following the presentation. The report should be paged numbered and be between five and ten pages double space, including embedded figures. The following subheadings should be used.

    1. Title
    2. Summary of the Problem, restate the problem in one-half page.
    3. Experimental Design, write a detailed experimental plan of study, reference the source of any reagents (either commercial or donated), tissues, organisms or biological material that you will use in your study. Your plan of study must contain the following:

    • Plan A: description of experimental design and control experiments.
    • Plan B: description of experimental design and control experiments.
    • Plan C: description of experimental design and control experiments.

    4. Anticipated Results from Plan A, B and C, drawings, diagrams, graphs, chromatograms, gels or numerical data illustrating the desired outcome of plan A-C (this section may be integrated in plan A-C above).
    5. Potential Pitfalls, point out what your group felt is the weakest or riskiest part of the plan.
    6. Timeline: provide a timetable to achieve each part of the Plan of Study,
    7. References: provide a citation list of reference used throughout sections 2-4.
    8. Participation: indicate the relative contribution of each member of the team.

    Schedule of Presentations

    Fall 2014

    Aug 28 -- Prof. Dawn Quelle, "Welcome / Introduction to the Course and Proposal Writing Discussion and Tips"
    Sept 18 -- Prof. Dawn Quelle, "Mock Study Section"
    Oct 2 -- Prof. Fred Quelle, "Ubiquitination/Deubiquitination Systems in Signaling and Regulation"Nov
    Nov 6 -- Prof. Fred Quelle, Class Workshop, Review of Specific Aims"

    Spring 2014

    Jan 30 -- Prof. Dave Roman, "Course Overview and Discussion of Grant Reviews", "Tips for Success Grant Writing"
    Feb 27 -- Prof. Dave Roman, "Mock Study Section"
    Mar 6 -- Prof. Tom Rutkowski, "ER Stress and Its Impacts on Cell Fate"
    Apr 17 -- Prof Tom Rutkowski, "Class Workshop"

    Fall 2013

    Aug 29 -- Prof. Dawn Quelle, "Welcome / Introduction to the Course and Proposal Writing Discussion and Tips"
    Sept 30 -- Prof. Dawn Quelle, "Mock Study Section"
    Oct 3 -- Prof Yuriy Usachev, "Functional Fluorscent Microscopy for Studying Neuronal Toxicity and Survival Mechanisms"
    Nov 7 -- Prof Yuriy Usachev, "Class Workshop, Review of Specific Aims"

    Spring 2013 

    Feb 7 -- Prof. Kevin Rice, "Orientation and Discuss the Proposal Reviews"
    Feb 28 -- Prof. Kevin Rice, "Mock Study Section"
    Mar 7 -- Prof. Adam Dupuy, "Using Forward Genetic Screens to Understand Acquired Chemotherapy Resistance in Cancer"
    Apr 4 -- Prof. Ray Hohl, "Distortion of the Isoprenoid Pathway - Feast or Famine"

    Fall 2012

    Aug 30 -- Prof. Dawn Quelle, "Welcome / Introduction to the Course and Proposal Writing Discussion and Tips"
    Sept 27 -- Prof. Dawn Quelle, "Mock Study Section"
    Oct 1 -- Justin Dassie, Postdoctoral Research Fellow, "RNA aptamer-siRNA Technology and Uses"
    Nov 1 -- Prof. Toshi Kitamoto, "Analyses of Sleep Behavior in Drosophila" 

    Spring 2012 

    Feb 2 -- Prof. Kevin Rice, "Discussion of Course"
    Feb 29 -- Prof. Kevin Rice, "Mock Study Section"
    Mar 1 -- Prof. Molly Martin, "G Protein-Coupled Receptors as Targets for PET Imaging of Tumors"
    Apr 5 -- Prof. Jonathan Doorn, "Microglial activation by an Endogenous Neurotoxin-Toxicity to Dopaminergic Cells"

    Fall 2011

    Sept 1 -- Prof. Dawn Quelle, "Welcome / Introduction to the Course and Proposal Writing Discussion and Tips"
    Sept 29 -- Prof. Dawn Quelle, "Mock Study Section"
    Oct 6 -- Prof. Rory Fisher, "Biology and Functions of RGS6"
    Nov 3 -- Prof. Anne Kwitek, "Genetic and Genomic Approaches to Understanding the Metabolic Syndrome"

    Spring 2011

    Feb 3 -- Prof. David Wiemer, "Exploring RAb GGTase Inhibition""
    Mar 31 -- Prof. Kevin Rice, "Mock Study Section"
    Apr 7 -- Prof. Michael Wright, "Mass Spectrometry-based Proteomics and the Study of Human Diseases"

    Fall 2010

    Aug 26 -- Prof. Dawn Quelle, "Welcome and Overview of the Course Discussion of Writing Proposals with a Focus on Experimental Plan Sections"
    Sept 2 -- Prof. Curt Sigmund, "Why do Thiazolidinediones Lower Blood Pressure?"
    Oct 7 -- Prof. Dan Quinn, "Analysis of Slow, Tight-binding Enzyme Inhibitors in Drug Design"
    Nov 4 -- Prof. Tina Tootle, "Genetic Analyses of Lipid Signaling"

    Spring 2010

    Feb 4 -- Prof. Michael Henry, "Imaging and Pharmacology
    Mar 4 -- Prof. Songhai Chen, "Application of Animal Models to Study Breast Cancer"
    Apr 8 -- Prof. Stefan Strack, "Protein Phosphatase 2A in Neurodegeneration: Evaluating a New Therapeutic Target"

    Fall 2009

    Sept 3 -- Profs. Dawn Quelle and Barry Kasson, "Welcome and Overview of the Course Discussion of Writing Proposals with a Focus on Experimental Plan Sections"
    Oct 15 -- Prof. Wendy Maury, "Identification of Cellular Receptors for Viruses"
    Nov 12 -- Prof. John Koland, "Submicroscopic Spatial Organization of Signaling Molecules in the Cytoplasmic Membrane: Experimental Approaches"
    Dec 10 -- Prof. David Roman, "Probing Protein Protein Interactions for Novel Drug Targets"

    Spring 2009

    Feb 5 -- Prof. Kevin Rice, "Peptide Synthesis and Targeted Drug Delivery"
    Mar 5 -- Prof. Gail Bishop, "Identification of Ligands for Newly Identified Receptors"
    Apr 9 -- Prof. Kathleen Sluka, "Animal Models of Pain and Selective Targeting in Brain"

    Fall 2008

    Sept 4 -- Profs. Dawn Quelle and Kevin Rice, "Welcome and Overview of the Course"
    Oct 2 -- Prof. Shahram Khademi, "Determine the Ligand Conduction in Membrane Channels Using Stopped-flow Spectrophotometry on Proteoliposomes"
    Nov 6 -- Prof. Donna Hammond, "Measures of Nociception"
    Dec 11 -- Prof. Greg Friestad, "Synthesis of Bioactive Peptides Containing Unusual Amino Acids"

    Spring 2008

    Feb 7 -- Prof. Mark Anderson, "Elucidating Cell Oxidation and Calcium Signaling"
    Mar 6 -- Prof. Jonathan Doorn, "Utility of Mass Spectrometry to Study Protein Modification"
    Apr 3 -- Prof. Mary Horne, "Analysis of Cell Cycle by Flow Cytometry"

    Fall 2007

    Sept 6 -- Profs. Dawn Quelle and Kevin Rice, "Course Overview and Discussion on "How to Write a Strong Proposal"
    Oct 4 -- Prof. Yuriy Usachev, "Fluorescent Indicators for Studying Neuronal Toxicity"
    Nov 1 -- Prof. Ernesto Fuentes, "NMR in Pharmacological Research"
    Dec 6 -- Prof. Robert Kerns, "Strategies for the Rational Design of Therapeutic Agents Based on the Discovery and Understanding of Biomolecular Interactions"

    Spring 2007

    Feb 1 -- Prof. Raymond Hohl, "Animal Models for Human Genetic Disease"
    Mar 1 -- Prof. Mike Duffel, "3D QSAR in the Prediction of Drug Metabolism"
    Apr 5 -- Prof. Dawn Quelle, "Assessing Function Through Molecular Associations"

    Fall 2006

    Sept 9 -- Prof. Rick Domann, "Modern Approaches to Study Epigenetic Control of Gene Expression"
    Oct 5 -- Prof. Don Heistad, "Applicaions of Gene Transfer to Study Cardiovascular Biology"
    Nov 2 -- Prof. David Sheff, "Approaches to Studying endocytic Traffic"
    Dec 7 -- Prof. Scott Moye-Rowley, "Saccharomyces Cerevisiae as a Problem for Understanding Eukaryotic Drug Metabolism"

    Spring 2006

    Feb 2 -- Prof. Amnon Kohen, "Crystal Structures as a Basis for Rational Drug Design- The Dynamic Paradox"
    Mar 2 -- Prof. S. Ramaswamy, "The Dos and Don'ts of Structure Assisted Ligand Design (Chalktalk - Hands-on Computer Work)"
    Apr 6 -- Prof. Stefan Strack, "Using RNA Interference to Study and Treat Neurodegeneration"

    Fall 2005

    Sept 1 -- Prof. Michael Henry, "Imaging and Pharmacology"
    Oct 6 -- Prof. Andy Russo, "Advent of New Migraine Therapies"
    Nov 3 -- Prof. Johannes Hell, "Strategies to Develop Drugs for Stroke Treatment"
    Dec 1 -- Prof. David Wiemer, "Fluorescent Labeling of Lipoproteins"

    Spring 2005

    Feb 3 -- Prof. Kevin Rice, "Photoaffinity Labeling of Receptors"
    Mar 3 -- Prof. Jerry Gebhart, "Knockout Mice"
    Apr 7 -- Prof. Tom Prisinzano, "Agonist, Antagonist, or Inverse Agonist"