Specimen:

Whole blood

Collection Medium:

Minimum:

Adult minimum: 3 mL whole blood in lavender top (EDTA) tube

Testing
Schedule:

Weekly

Analytic Time:

14 days

Reference Range:

By report

Comments:

This test is available to symptomatic individuals only.  Predictive 
testing is not offered because this variant demonstrates reduced 
penetrance.  The LRRK2 G2019S variant is found in approximately 6% of 
families demonstrating autosomal dominant inheritance of PD and in 
approximately 1% of sporadic cases.

Test
Limitations:

Testing on smaller blood volumes than those requested will be 
attempted.  However, in some cases, small blood volumes may compromise 
the ability to perform testing.

Methodology:

Polymerase Chain Reaction: Amplification refractory mutation system 
(ARMS).

Sample
Processing:

Lavender tube is sent as whole blood, no processing necessary.

Sample
Storage:

Room temperature for up to 24 hours, then refrigerate the whole blood 
if it is necessary to be held overnight, or weekends, or holidays.

Transport
Instructions:

DO NOT FREEZE, protect specimen by wrapping in bubble-wrap or toweling.
Recommend express mail or equivalent if not on courier service.
Place specimen into styrofoam container, seal container.

CPT Code:

83894, 83900, 83890, 83912