The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK


FISH, HES/Leukemia, 4q12 Rearrangement (FIP1L1-PDGFRA)
Order Code: FIP
Epic Lab Code: LAB4805
Order Form: A-1a Miscellaneous Request or Epic Req
  Commercial "Mail-out" Laboratory
6240 RCP
356-3527
Specimen:
Bone Marrow or Whole Blood
Collection Medium:
Green top tube (Na Heparin)
Minimum:
3 mL bone marrow or 3 mL whole blood
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.
Specimen
Instructions:
Collect Monday - Thursday only.
Do not collect before a weekend or holiday.  Specimen must be received 
by referral laboratory within 72 hours of collection.
Analytic Time:
10 days upon receipt
Interpretive Data:
FIP1L1-PDGFRa fusion (rearrangement of 4q12; interstitial deletion of 
CHIC2 region) is observed in diverse eosinophilia-associated 
hematologic disorders. The cases with FIP1L1-PDGFRa fusion show an 
excellent response to the tyrosine kinase inhibitor imatinib mesylate 
(Metzgeroth et al, 2007).
Methodology:
Fluorescence in situ hybridization (FISH)
CPT Code:
88275, 88291, 88271 (x3)

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Updated: 10/21/2009

Note: The information contained in this handbook is for use by personnel of University of Iowa Health Care. No other use is implied or intended.