The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK

Infliximab/HACA Measurement
Order Code: HACA
Epic Lab Code: LAB3417
Order Form: A-1a Miscellaneous Request or Epic Req 		  Commercial "Mail-out" Laboratory
6240 RCP
356-3527 
Specimen:
 
Serum
Collection Medium:
Red top tube 


Minimum:


Adult Minimum:  2 mL serum
Pediatric Minimum:  0.50 mL serum


Delivery Instructions:


Deliver to laboratory immediately after collection.


Analytic Time:


7 working days


Reference Range:


Assay: HACA
Serum Infliximab Measurement:  <1.40 mcg/mL
Human Anti-Chimeric Antibody (HACA):  <1.69 mcg/mL equivalents


Interpretive Data:


Serum infliximab concentrations may vary among equally dosed patients.  
Measuring serum infliximab levels can aid physicians in determining the 
dose of infliximab and guide infusion intervals.  The HACA portion of 
the test detects Human Anti-Chimeric Antibodies (antibodies against 
infliximab).  Patients that develop HACA may experience infusion 
reactions and/or a reduced duration of efficacy of infliximab.


CPT Code:


83520(x2)


 


See Additional Information:
Specimens Requiring Immediate Delivery




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Updated: 03/11/2009

Note: The information contained in this handbook is  
            for use by personnel of University of Iowa Health Care. 
            No other use is implied or intended.