The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK


Voriconazole Antifungal Drug Level
Order Code: VORI
Epic Lab Code: LAB4267
Order Form: A-1a Miscellaneous Request or Epic Req
  Commercial "Mail-out" Laboratory
6240 RCP
356-3527
Specimen:
Serum
Collection Medium:
Red top tube
Minimum:
Draw blood in a plain red-top tube(s). Spin down and send 2 mL of serum 
frozen in plastic vial.
Analytic Time:
7 working days
Reference Range:
1.0-5.5 mcg/mL

Trough level (i.e., immediately before the next dose) monitoring is 
recommended.
Interpretive Data:
Trough levels >6 mcg/mL (and especially >10 mcg/mL) have been 
associated with toxicity in several reports. Trough levels <1 mcg/mL 
have been associated with suboptimal response in several reports.

Cautions:  Voriconazole metabolism may be altered by coadministration 
of drugs that metabolically induce or inhibit CYP2C19 or by genetic 
polymorphisms that affect enzyme activity.
Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
CPT Code:
82491

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Updated: 05/13/2009

Note: The information contained in this handbook is for use by personnel of University of Iowa Health Care. No other use is implied or intended.